Karolinska Institutet

This study tests whether infusions of donated fetal stem cells can safely help babies with a severe form of osteogenesis imperfecta (brittle bone disease). The treatment aims to reduce fractures and improve bone strength. The trial includes up to 18 children, some treated before …

This study planned to test two new methods for spotting acute kidney injury (AKI) early in adults having heart surgery. Researchers wanted to see if these methods could predict AKI better than current tests. However, the study was withdrawn before any participants were enrolled, …

This study tests whether giving women structured online birth control advice when they pick up the morning-after pill helps them switch to a regular, more effective method. About 600 women in Sweden will take part. The goal is to see if this simple digital tool increases use of r…

This study tests a new online program called Tiny Heroes, designed to help parents reduce anxiety in their 3-6 year old children. The program is a type of cognitive behavioral therapy that parents do at home. Researchers want to see if it is practical and helpful, and will use fe…

This study looks back at 65 adults who had one of two surgeries for a painful jaw joint condition (TMJ disc displacement). The goal is to see which surgery—anterior release or discectomy—better improves mouth opening, reduces pain, and speeds recovery. Researchers will also check…

This study tests whether a brief online version of Parent-Child Interaction Therapy can help reduce disruptive behaviors in children aged 2-7 years. Twenty parents will receive a 10-week online intervention and fill out weekly questionnaires. The goal is to see if this approach i…

This study compares two internet-based cognitive behavioral therapy programs for adults with generalized anxiety disorder. About 400 participants will receive one of two 10-week online treatments targeting either intolerance of uncertainty or negative beliefs about worry. The goa…

This study tests a 10-week web-based program called DRIV for adults with long-term spinal cord injury. Participants attend weekly online group sessions covering exercise, nutrition, and stress management. Researchers compare them to a waitlist group to see if the program improves…

This study tests a 12-week play-based training program for children aged 2-5 with cerebral palsy. Kids use special running bikes and other aids to improve their ability to move and be active. The goal is to see if these fun group sessions can boost their gross motor skills and ov…

This study follows 7,500 men aged 50-74 to see if using a combination of PSA, a biomarker test, and MRI leads to better long-term outcomes, including fewer deaths from prostate cancer. Participants were invited for screening and compared to those who had standard PSA testing or n…

This study looks at why people with post-COVID syndrome feel extremely tired and have trouble exercising. Researchers will compare how 62 people with long COVID and healthy volunteers respond to three types of exercise: moderate walking, intense intervals, and strength training. …

This study tests whether a brief online program can help people who drink too much feel less embarrassed or worried about getting help. Many people avoid seeking help due to shame or fear of consequences, even though effective treatments exist. The study will ask 200 participants…

This study looks at large DNA changes in 10,000 people with rare genetic conditions or brain disorders. Researchers will map these changes in detail to understand how they cause disease. The goal is to improve genetic testing and find new targets for treatments.

This study tests a program called Little ACF, designed to help parents of children aged 1-2 years strengthen their parenting skills and support their child's emotional development. Around 670 families from child health centers will take part, with some receiving the program and o…

This study looks at whether having a resuscitation order other than 'full code' is linked to a higher chance of dying in the ICU. Researchers will analyze data from 1,500 critically ill patients, considering age, sex, illness severity, and frailty. The goal is to see if the incre…