Karolinska Institutet

This study looks at whether a single dose of the HPV vaccine can prevent infection with several types of HPV in young adult women. Researchers are tracking 150,000 women in Sweden born between 1994 and 1999 who received one vaccine dose. The goal is to see how well one dose works…

This study compares two types of wrist fusion surgery for people with advanced wrist arthritis (SNAC or SLAC). The goal is to see if one surgery gives better grip strength and function than the other. About 64 adults with grade 2-3 arthritis will be randomly assigned to one of th…

This study tests a treatment using donated fetal stem cells given through an IV to infants with a severe form of osteogenesis imperfecta (brittle bone disease). The goal is to see if it is safe and can reduce fractures and improve bone strength. Some babies may receive the cells …

This study tests whether adding 10 in-home decluttering sessions to group cognitive-behavioral therapy can reduce hoarding severity in adults with hoarding disorder. About 90 participants in Sweden will receive both the group therapy and personalized home visits focused on guided…

This study tests whether a single type of cognitive-behavioral therapy (CBT) can work for several anxiety disorders, compared to therapies designed for each specific disorder. About 76 adults with panic disorder, generalized anxiety, social anxiety, OCD, or PTSD will participate.…

This study tests a four-module online program called Tiny Heroes, which teaches parents of anxious 3-6 year olds cognitive behavioral therapy techniques. 24 families in Sweden will try it to see if it's easy to use and helps reduce children's worry and fear. If the results are go…

This study tests an online therapy program called IERITA for teens aged 13-17 who have hurt themselves without intending suicide. The program teaches emotion regulation skills through videos, readings, and therapist messages over 12 weeks. Researchers want to see if the approach …

This study tests whether an online cognitive behavior therapy (CBT) program can help children aged 8 to 17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. The st…

This study aimed to compare different treatments—like mouthguards, jaw exercises, and anti-inflammatory drugs—for jaw muscle or joint pain in children aged 7 to 14. The goal was to see which works best and if any affect jaw growth. However, the study was withdrawn before enrollin…

This study looks back at 65 adults who had one of two surgeries for a painful jaw joint condition (TMJ disc displacement). The goal is to see which surgery better improves mouth opening, reduces pain, and helps the jaw work better. Researchers also check recovery speed, side effe…

This study tests whether a 10-week online therapy program can help parents of children aged 2-7 with disruptive behaviors. The program combines online lessons with live video coaching. Twenty families will participate, and researchers will measure changes in child behavior and pa…

This study tests a 12-week play-based training program for children aged 2-5 with cerebral palsy. The program uses running frames and other assistive devices to improve mobility, fitness, and daily activity. Twenty children will participate in weekly group sessions plus home exer…

This study tests whether giving local anesthesia during the pushing stage of labor can lower the chance of perineal tears (including severe muscle injuries) in women having their first vaginal birth. About 1,350 first-time mothers will take part. If effective, this simple step co…

This study compares two internet-based cognitive behavioral therapy programs for people with generalized anxiety disorder. About 400 adults will receive one of two 10-week online treatments targeting either intolerance of uncertainty or unhelpful beliefs about worry. Researchers …

This study aimed to create and test a website that helps people in Sweden decide whether to participate in cancer screening for breast, colorectal, and ovarian cancers. The goal was to provide clear, balanced information so people can make choices based on knowledge rather than f…

This study planned to test two new methods for spotting acute kidney injury early in adults having heart surgery. Researchers wanted to see if these methods could predict kidney damage better than current tools. However, the study was withdrawn before any volunteers were enrolled…

This study tested whether two methods for measuring nerve function in the fingers give consistent results. Ten healthy adults had their fingers tested twice, two weeks apart. The goal was to see if the methods are reliable enough to use in future studies. No treatment or cure was…

This study looks at large DNA changes in 10,000 people with rare diseases or chromosome abnormalities. Researchers will use genome sequencing and lab models to understand how these changes cause brain disorders. The goal is to improve genetic diagnosis and pave the way for future…

This study looks at why people with post-COVID syndrome feel extremely tired and have trouble exercising. Researchers will compare 62 people with long COVID to healthy volunteers by testing their response to three types of exercise: moderate walking, intense intervals, and streng…

This study tests whether giving women structured online contraceptive advice when they buy the morning-after pill at a pharmacy helps them switch to a regular, effective birth control method. About 600 women in Sweden will use a smartphone app to get counseling and will be follow…

This study follows 7,500 men aged 50-74 to compare long-term outcomes of different prostate cancer screening methods. Some men were invited to a screening program using PSA, a biomarker test, and MRI, while others had only a single PSA test or were part of a control group. Resear…

This study tests a program called Little ACF, designed to help parents of children aged 1-2 years strengthen their parenting skills and support their child's emotional development. About 670 parents from child health clinics will be randomly assigned to either the program or usua…

This study tests a method to improve workplace health by focusing on positive factors like fairness and leadership, rather than just fixing problems. About 45 municipal employees will set goals and track progress using a tool called Goal Attainment Scaling. Researchers want to se…

This study tests whether a brief information session can help people with risky alcohol use feel more comfortable seeking help. Many avoid help due to shame or fear of consequences, even though effective treatments exist. Researchers will measure changes in participants' willingn…

This study tests a 10-week online education program for women aged 18-40 with functional hypothalamic amenorrhea (a condition where periods stop due to stress, low weight, or exercise). The goal is to see if the program is easy to use and helpful, before testing it in a larger st…

This study looks at whether using snus (including newer nicotine pouches) is linked to heart disease, poor metabolism, and mental health issues, separate from smoking. Researchers are analyzing health data from over 30,000 Swedish adults, including CT scans and blood tests, to co…

This study tests a 10-week online health program for adults with long-term spinal cord injury. Participants attend weekly video sessions on exercise, diet, and stress, and wear an activity monitor. Researchers compare them to a waitlist group to see if the program improves lifest…

This study looks at whether having a resuscitation order other than 'full code' is linked to a higher risk of death in critically ill patients. Researchers will analyze data from 1500 ICU patients, considering factors like age, sex, and frailty. The goal is to see if the increase…