Why do Post-COVID patients feel so tired? new study investigates exercise responses
NCT ID NCT05445830
First seen Jun 26, 2026 · Last updated Aug 07, 2026 · Updated 2 times
Summary
This study looks at why people with post-COVID syndrome have trouble exercising and feel very tired. Researchers will compare 62 post-COVID patients with healthy volunteers, monitoring their responses to different types of exercise like high-intensity intervals, moderate walking, and strength training. The goal is to find out what causes these symptoms and how to improve care and rehabilitation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- High-Intensity-Interval-Exercise (HIIE), moderate intensity continuous exercise, and strength training
- What this could lead to
- If successful, this study could help doctors understand the causes of fatigue and exercise problems in post-COVID patients, leading to better rehabilitation programs.
- What could go wrong
- This is an observational study with only 62 participants, so results may not apply to everyone. It aims to understand symptoms, not test a treatment, so no direct benefit is guaranteed.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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62 people
The number who actually took part.
- Started
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Sep 2022
- Finished
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Dec 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 64 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Verified test of covid-19 infection (PCR, or antigen or antibody before vaccination) (mandatory only for post-COVID group) * Symptoms persisting for at least 3 months (validaded with DSQ-PEM questionnarie) (only for post-COVID group) Exclusion Criteria: * Subject's complaints may have been present before March 2020 * Previous history cardiovascular, respiratory disease or other autoimmune disease * History of general anxiety syndrome or somatic symptom disorder
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Karolinska University Hospital Huddinge
Stockholm, Huddinge, 141 57, Sweden
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Blood filtering shows promise for chronic fatigue sufferers
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- Could a gentle zap to the neck ease long COVID fatigue?
- Oxygen chamber treatment tested for long COVID fatigue relief