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Simple supplement and rehab program shows promise for Post-COVID recovery

NCT ID NCT07544186

Disease control Sponsor: Instituto Nacional de Enfermedades Respiratorias Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether a combination of L-citrulline supplements, nutritional therapy, and pulmonary rehabilitation could help recovered COVID-19 patients improve their blood vessel health, body composition, and physical function. 43 adults aged 40-80 who had recovered from COVID-19 took part. The intervention group received daily L-citrulline and nutritional guidance for 3 months, while both groups underwent pulmonary rehab. The goal was to see if this non-drug approach could ease lingering post-COVID issues.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
L-citrulline (a dietary supplement) combined with nutritional therapy and pulmonary rehabilitation
What this could lead to
If successful, this approach could offer a simple, non-drug way to help people recover from lingering COVID-19 symptoms like fatigue and poor physical function.
What could go wrong
This is a small, completed study with only 43 participants, so results may not apply to everyone. The supplement and rehab may not produce clear benefits over standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

43 people

The number who actually took part.

Started

Nov 2020

Finished

Aug 2023

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Recovered COVID-19 patients with a negative PCR test for SARS-CoV-2. * Subjects between 40 and 80 years. * Subjects who give written informed consent to participate in the study. Exclusion Criteria: * Subjects diagnosed with Human Immunodeficiency Virus (HIV). * Subjects diagnosed with cancer. * Subjects with a glomerular filtration rate (GFR) \<30 ml/min/1.73 m². * Subjects currently enrolled in another interventional study.

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Conditions

The condition(s) this trial relates to.

long COVID-19 post-COVID-19 disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endothelial function Post COVID syndrome Supplemental nutrition assistance program education

Contacts and locations

Locations

  • Instituto Nacional de Enfermedades Respiratorias

    Mexico City, Mexico

More trials for these conditions

Other studies related to the condition(s) this trial covers.