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Walking program shows promise for liver patients

NCT ID NCT06288828

Symptom relief Sponsor: King Chulalongkorn Memorial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether a 16-week brisk walking program, combined with dietary advice, could improve heart rate control and blood vessel health in adults with early-stage cirrhosis (liver scarring). Fifty participants aged 45-75 who were not very active took part. The goal was to see if exercise could help the body's automatic functions work better.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Mar 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

45 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The diagnosis of cirrhosis is confirmed either through liver biopsy ,and/or compatible features on ultrasonography/ computer tomography or magnetic resonance imaging. * The age range is between 45 and 75 years. * Participants are classified as Child Pugh score class A. * Participants report a physical inactivity, defined as engaging in physical activity for less than 150 minutes of moderate-intensity physical activity per week, or less than 75 minutes of vigorous-intensity physical activity per week, or an equivalent combination of both. Exclusion Criteria: * Active hepatocellular carcinoma (HCC) or remission of HCC within the past 3 months. * Untreated large esophageal varices (EV) greater than F2 or history of upper gastrointestinal bleeding from portal hypertension or gastric varices. * Active or history of hepatic encephalopathy (HE). * Inpatient hospitalization for any reason or discharge from the hospital within the past 3 months. * Complete portal vein thrombosis. * Transjugular intrahepatic portosystemic shunt. * Contraindications to exercise, such as recent myocardial infarction, unstable angina, electrocardiography changes within the past 24 hours, complete heart block, acute congestive heart failure, uncontrolled hypertension, hemoglobin level less than 11 g/dL, platelet count less than 50,000 cells/mm 3 . * End-stage renal disease without dialysis. * Severe orthopedic problems that limit the ability to exercise. * Inability to communicate with the research team via telemedicine system. * Body mass index (BMI) exceeding 35 kg/m 2 . * On alpha or beta-blocker

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Conditions

The condition(s) this trial relates to.

autonomic nervous system disorder cirrhosis of liver Fibrosis Motor Activity primary dysautonomia Sarcopenia Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aerobic exercises Autonomic dysfunction Autonomic nervous system Cirrhosis Endothelial function Flow mediated dilation Heart rate variability Lifestyle modification Physical activity Physical functional performance Physical inactivity Sarcopenia

Contacts and locations

Locations

  • Faculty of medicine, King Chulalongkorn Memorial Hospital

    Bangkok, Bangkok, 10330, Thailand

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