AUTONOMIC DYSFUNCTION

This study tests whether a fast-acting drug called landiolol can keep heart rate below 90 beats per minute during major surgery, which may reduce the risk of heart injury. It involves 114 adults aged 45 or older with heart risk factors who are having elective non-cardiac surgery.…

This study tests whether a non-invasive spinal cord stimulation device can help people with chronic spinal cord injury improve autonomic functions like blood pressure, bladder, bowel, and sexual control. About 30 adults with complete paralysis at or above T6 will receive targeted…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device aims to improve sleep quality, which may also reduce the risk of heart disease. Researchers will measure sleep, blood vessel health, and nervous system…

This study tests whether a noninvasive spinal cord stimulation device can safely improve bladder, bowel, sexual, and heart function in people with spinal cord injury. About 60 veterans in Canada and Ukraine will receive either real or sham stimulation alongside standard rehab. Th…

This study tests whether adding a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) to standard rehabilitation can improve heart rate variability (a sign of healthy heart control) in 44 stroke survivors. Participants will receive …

This study looks at why some children with high blood pressure develop heart or kidney damage. Researchers will measure certain chemicals in the blood and urine of 125 children aged 7-18 with a new diagnosis of high blood pressure, as well as healthy children. The goal is to bett…

This study looks at how the autonomic nervous system (which controls heart rate and blood pressure) works in people with Down syndrome. Researchers will measure heart rate, blood pressure, and stress hormones during activities like cold exposure, fear simulations, and exercise. T…

This study looks at how the body regulates blood pressure and heart rate in healthy adults and older adults with high blood pressure. Participants will undergo tests like standing up and exercising on a stationary bike while their heart activity and artery stiffness are measured.…

This observational study will follow up to 1,000 adults with conditions like fainting, rapid heartbeat, or low blood pressure who have had or will have a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The goal is t…

This study looks at why some people develop POTS (a condition causing rapid heartbeat and dizziness) after COVID-19. Researchers think a part of the nervous system that normally fights inflammation may not work well in these patients. They will measure immune cells and inflammati…