Karolinska Institutet

This study looks at women with breast cancer that has spread to lymph nodes under the arm, found before surgery. Normally, doctors remove many lymph nodes, which can cause arm swelling and pain. The trial tests if removing only the first few lymph nodes (sentinel nodes) plus the …

This study tests a 10-week psychoeducational program for women with Functional Hypothalamic Amenorrhea (FHA), a condition where periods stop due to stress, low energy, or lifestyle factors. About 70 women will either join the program or receive usual care. Researchers will track …

This phase 3 trial tests whether giving personalized doses of tamoxifen (based on how each person processes the drug) helps more women with hormone-sensitive breast cancer stay on treatment and have better outcomes. Currently, 30-50% of patients stop tamoxifen early due to side e…

This study tests a new way to help families prevent and manage childhood obesity. It combines two programs: one for all first-grade students and their families, and another for parents of children who are already overweight or obese. The goal is to see if this combined approach i…

This study will observe 400 adults with sepsis and unstable blood pressure to see how their heart and blood vessels are affected. Participants will have heart ultrasounds, blood tests, and blood vessel checks within 72 hours of hospital admission. The goal is to link these findin…

This study looks at whether a device called Q-NRG+ can accurately measure energy expenditure in critically ill infants weighing less than 10 kg in the pediatric intensive care unit (PICU). Researchers will test the device on 80 newborns and small children who are either on a vent…

This study looks at how people with mild intellectual disability process emotions compared to those with autism and typically developing individuals. It also tests a 24-week therapy program designed to help improve emotion regulation. The goal is to better understand these differ…

This study looks at adults with a hernia on both sides of the groin, where one side causes symptoms and the other does not. It compares fixing both hernias at once versus only fixing the painful side. The goal is to see which approach results in less long-term pain and fewer comp…

This study looks at how well a program helps nurses in child health services ask parents about family violence. Researchers will check medical records of 90,000 parents and interview nurses to see what helps or hinders these conversations. The goal is to learn how to better ident…

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who have already completed a larger trial comparing two therapies: metacognitive therapy (MCT) and cognitive-behavioral therapy (CBT). The goal is to understand what participants thought about each …

This study looks at 40 adults aged 16-50 with a single-chamber heart (Fontan circulation) to understand how muscle size and strength relate to their heart and lung function. Researchers will measure oxygen use, muscle mass, and quality of life. The goal is to find out if muscle t…