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Could a blood concentrate ease chronic jaw pain? new trial aims to find out

NCT ID NCT07606378

Symptom relief Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 06, 2026 · Updated 2 times

Summary

This study tests whether injections of platelet-rich plasma (PRP) can reduce pain and improve jaw function in people with chronic jaw muscle pain (myogenous TMD). Fifty women aged 20–50 with at least 3 months of pain will receive either PRP or a saltwater shot, then be followed for 6 months. PRP is made from the patient's own blood and may help heal muscle tissue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Aug 2026

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * women 20 to 50 years with a confirmed diagnosis of myogenous TMD according to the DC/TMD * participants must have pain in the masticatory muscles * pain duration must be at least 3 months * participants must report current pain at the day of inclusion with a minimum score of 4 on the numeric rating scale (NRS 0 to 10) Exclusion Criteria: * active infection or inflammation at the injection site * systemic infection * platelet or coagulation disorders * severe anemia; * autoimmune or inflammatory rheumatic disease; * chronic liver diseases; * uncontrolled diabetes; * pregnancy or breastfeeding will also be exclusion criteria * individuals using anticoagulant or antiplatelet medication that cannot be temporarily discontinued or receiving chronic corticosteroid or immunosuppressive therapy * predominantly arthralgia temporomandibular disorders * previous temporomandibular joint surgery, or a history of significant trauma to the face, head, or neck, including orthognathic surgery * individuals with fibromyalgia * individuals with neuromuscular disorders such as craniomandibular dystonia or myasthenia gravis, diagnosed or severe psychiatric disease such as schizophrenia or bipolar disorder, neuropathic pain, or pain of dental origin * individuals unable to provide informed consent or complete study questionnaires will be excluded

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Conditions

The condition(s) this trial relates to.

Facial Pain masticatory muscles, hypertrophy of myofascial pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Masseter muscle Myofacial pain Myogenic temporomandibular joint disorders

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Karolinska Institutet - Department of Dental Medicine

    Huddinge, Stockholm County, 17177, Sweden

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