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Double shock strategy for cardiac arrest put to the test in pilot trial

NCT ID NCT06447805

Knowledge-focused Sponsor: Karolinska Institutet Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tested whether using two defibrillators early, instead of one, is feasible and safe for people whose hearts stop outside a hospital and don't respond to the first shock. Researchers enrolled 40 adults with a shockable heart rhythm. The goal was to see if emergency crews could follow the double-shock plan reliably and without harming patients. Results will help design a larger study to see if this approach saves more lives.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Double sequential defibrillation (using two defibrillators)
What this could lead to
If this approach proves feasible and safe, it could lead to a larger study that may improve survival for people whose heart rhythm doesn't respond to standard defibrillation.
What could go wrong
This is a small pilot study with only 40 participants, focused on feasibility, not on proving the treatment works. The results may not apply to all cardiac arrest patients, and there are risks like defibrillator malfunction or delays in CPR.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Aug 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Out-of-Hospital patients with Ventricular Fibrillation/ Ventricular Tachycardia at rhythm analysis after ambulance arrival and at least one defibrillation performed in standard (Antero-Lateral) position Exclusion Criteria: * Age below 18 years * Obvious pregnancy * Known preexisting Do Not Attempt Resuscitation order

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Conditions

The condition(s) this trial relates to.

cardiac arrest Death, Sudden, Cardiac sudden arrhythmia death syndrome sudden cardiac arrest ventricular fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest Fibrillation, ventricular Sudden cardiac arrest Sudden cardiac death

Contacts and locations

Locations

  • Emergency medical services Region Halland

    Halmstad, Halland County, 30238, Sweden

  • Sahlgrenska Universitetssjukhuset, Ambulans och Prehospital Akutsjukvård

    Gothenburg, Västra Götalandsregionen, 411 04, Sweden

  • Sjukhusen i väster, ambulanssjukvården Alingsås/Lerum

    Alingsås, Västra Götalandsregionen, 441 39, Sweden

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