SUDDEN CARDIAC DEATH

This study compares two common heart failure medications, carvedilol and metoprolol succinate, in 2,000 adults who have an implantable defibrillator (ICD). Participants currently taking metoprolol will be randomly assigned to either stay on it or switch to carvedilol. The goal is…

This study tests a new way to pace the heart in people with hypertrophic cardiomyopathy who have already had a myectomy (heart muscle trimming). The new method, called left bundle branch pacing, is compared to standard dual-chamber pacing. The goal is to see if it can prevent hea…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery grows from the wrong spot, which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and predict wh…

This study looks at whether heart attack survivors with weak hearts can do just as well with modern medications alone compared to getting a defibrillator implant. About 3,600 participants who have had a heart attack and have a weak heart pump will be randomly assigned to either g…

This study is looking for new genes and blood markers that can help predict who will get arrhythmogenic cardiomyopathy (AVC), a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1000 people, including patients with AVC or unexplained cardiac ar…

This study is looking at 1500 adults with coronary artery disease to find out which factors—like genetics, heart activity, blood markers, and lifestyle—best predict sudden cardiac arrest or death. Researchers hope to identify high-risk patients who could benefit from implantable …

This study watches how BTK inhibitors, a type of leukemia treatment, affect the heart's rhythm. About 135 adults with certain blood cancers who are taking or about to start these drugs will have heart tests like EKGs, stress tests, and heart imaging. The goal is to spot dangerous…

This study looks at tiny particles called exosomes in the blood of people who have had a sudden cardiac arrest. Researchers want to see if certain molecules in these particles can help predict who is at risk. The goal is to find better ways to identify high-risk patients early an…

This study is creating a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, or Marfan syndrome. Researchers will collect DNA samples and medical information to find out which genes are most commonly affected and how often thes…

This study is testing a cloud-based artificial intelligence program called Willem that reads electrocardiograms (ECGs) to detect heart rhythm problems and other abnormal patterns. Researchers will compare the AI's performance to that of board-certified cardiologists using data fr…

This study is testing whether new MRI and CT scans can better identify people at high risk for sudden cardiac death. Researchers will enroll 400 adults with weak hearts (ejection fraction 35% or less) who are scheduled to get an implantable defibrillator (ICD). The goal is to imp…