Periodontitis

Researchers test whether intentionally removing, treating, and replanting a severely loose lower front tooth works better than splinting alone. Fifty adults with advanced periodontitis and at least 50% bone loss around the tooth join the study. Half receive replantation plus spli…

This trial tests whether a toothpaste containing arginine can alter the bacteria living below the gumline in people with gum disease who are already receiving ongoing dental care. Participants will brush twice daily for six months with either an arginine toothpaste or a standard …

This trial is testing two ways of performing a deep dental cleaning, called scaling and root planing, in people with advanced gum disease (Stage III periodontitis). One method cleans the entire mouth in a single session, while the other cleans one quadrant of the mouth at a time …

This study tests whether adding concentrated platelet-rich fibrin (C-PRF), a gel made from a patient's own blood, to a minimally invasive non-surgical gum treatment can improve healing in people with advanced periodontitis. Thirty adults with severe gum disease and deep bone defe…

This pilot study tests whether using a videoscope—a small camera that gives surgeons a magnified, clearer view—during minimally invasive gum surgery improves outcomes for people with severe chronic periodontitis. Participants are randomly assigned to receive surgery with the vide…

This trial tests whether applying a gel containing hyaluronic acid and chlorhexidine after a minimally invasive deep cleaning can improve gum healing in people with advanced periodontitis (stage III or IV). Participants receive either the deep cleaning alone or the cleaning plus …

This trial tests whether a thin, strong fiber splint glued to the back of loose front teeth can keep them stable for a year. The splint is made of ultra-high molecular weight polyethylene and is placed after standard gum treatment. Researchers will track how many teeth survive, h…

This completed trial tested a new bone substitute called ALBO-OS in 20 people with periodontitis (severe gum disease) or needing jawbone preservation after tooth extraction. The material was placed into deep gum pockets or empty tooth sockets to help new bone grow. Early results …

This study looks at whether the timing of follow-up exams after non-surgical gum treatment affects how well the gums heal. Researchers will compare re-evaluations done at 3-4 months, 6-8 months, and 12 months after treatment. The goal is to see which timing leads to the most clos…

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study tests a minimally-invasive non-surgical therapy (MINST) for treating gum disease-related bone defects. The approach uses small instruments and magnification to clean deep gum pockets with less tissue damage than traditional surgery. Researchers will measure bone healin…

This study tests whether adding a special nano-gel (nano-hydroxyapatite) to a deep-cleaning gum treatment helps heal deep gum pockets better than cleaning alone. About 28 adults with advanced gum disease will be randomly assigned to get either the cleaning plus gel or just the cl…

This study tests whether adding nano-hyaluronic acid gel to a non-surgical deep cleaning procedure helps heal gum pockets better than cleaning alone. About 28 adults with moderate to severe gum disease will be randomly assigned to receive either the gel plus cleaning or just clea…

This study looked at whether adding a diode laser to standard deep-cleaning treatment helps people with gum disease (periodontitis). Twenty-one adults in Yemen received the combined treatment, and researchers measured plaque, gum bleeding, pocket depth, and immune markers in gum …

This study tests whether adding a diode laser to standard deep cleaning helps people with gum disease. Forty adults with periodontitis will receive either standard cleaning alone or cleaning plus laser. Researchers will measure gum pocket depth and inflammatory markers in saliva …

This study tests whether using a patient's own extracted tooth as a bone graft works as well as a traditional bone graft to repair bone damage from severe gum disease. Sixty adults with chronic periodontitis will receive one of the two graft types, both combined with a healing ge…

This study tests whether a new mouthwash that repairs enamel and fights bacteria works better than a standard chlorhexidine mouthwash for treating gum disease. About 40 adults with mild to moderate gum disease will use one of the mouthwashes along with deep cleaning. The goal is …

This study tests whether a blackberry extract mouthwash works as well as a standard antiseptic mouthwash (chlorhexidine) for treating gum disease. 48 adults with periodontitis will receive standard deep cleaning and then rinse with one of the mouthwashes or just plain water. Rese…

This study tests whether adding aspirin and omega-3 fatty acids to standard deep-cleaning gum treatment helps people with advanced gum disease (periodontitis). About 120 adults will be randomly assigned to get either standard cleaning alone, cleaning plus omega-3, or cleaning plu…

This study looks at whether deep cleaning for gum disease can lower a key heart failure marker in the blood. About 80 adults with or without heart failure will receive dental scaling and root planing. Researchers will track changes in NT-proBNP levels and gum health over 6 months…

This study tests whether a protein from camel milk, made into tiny nanoparticles, can help repair bone damage caused by severe gum disease. About 44 adults with deep gum pockets and bone loss will receive the treatment during surgery. The goal is to see if the camel protein helps…

This study tests whether a gel made from ferulic acid, a natural antioxidant, can improve the results of deep cleaning for gum disease. Researchers will compare three groups: cleaning plus the gel, cleaning plus a placebo gel, and cleaning alone. The goal is to see if the gel hel…

This early-stage trial tests whether injecting resveratrol nanoparticles into the gums can improve treatment for stage III periodontitis. 48 adults will receive either the resveratrol gel, a placebo, or standard deep cleaning alone. Researchers will measure gum attachment levels …

This study tested whether adding injectable Platelet-Rich Fibrin (i-PRF), a natural concentrate from a patient's own blood, to standard deep cleaning improves gum disease outcomes. In 13 adults with moderate to severe periodontitis, one side of the mouth received the combined tre…

This study compares two types of minimally invasive gum surgery for treating deep pockets caused by periodontitis. Fifty adults with advanced gum disease will be randomly assigned to receive either a single-flap or double-flap procedure. Researchers will measure how well each tec…

This study tests whether a melatonin-loaded gel, made from your own blood, can improve gum health in people with stage II periodontitis. About 60 adults with mild to moderate gum disease will receive the treatment. The main goal is to see if it helps reattach gums to teeth.

This study reviews past dental records to see how effective scaling and root planing (a deep cleaning procedure) is for treating gum pockets that are 5 to 8 millimeters deep. Researchers will analyze data from 110 patients treated by dental students over two years. The goal is to…

This study tests whether adding a concentrate from the patient's own blood (injectable platelet rich fibrin, or I-PRF) to a standard bone graft helps repair bone defects caused by advanced gum disease. Twenty adults with stage III periodontitis and deep gum pockets will receive e…

This study tests whether treating severe gum disease can slow down Alzheimer's disease. Researchers will give 26 people with both conditions deep dental cleaning, extractions if needed, and oral hygiene training. Over 24 months, they will track memory, thinking skills, and brain …

This study looks at two ways to treat severe gum disease that has reached the area where the roots of back teeth split. One approach uses non-surgical cleaning and maintenance, while the other involves surgery to reshape or rebuild bone. The goal is to see which method helps keep…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

Researchers compare whether adding omega-3 or resveratrol supplements to standard non-surgical gum treatment improves periodontal health in healthy non-smokers with periodontitis. The study looks back at records from 60 patients split into three groups: those who took resveratrol…

This study tests a numbing method called intraseptal anesthesia for gum surgery. Sixty adults with gum disease will receive a small amount of articaine to see if it effectively blocks pain during the procedure. The goal is to find a less painful alternative to standard numbing te…

Researchers at Semmelweis University are studying whether bacteria that cause gum disease also show up in damaged blood vessels. They will compare samples from the mouth and from diseased artery sites in 100 people who need surgery for aortic aneurysm or carotid artery narrowing.…

This study looks at whether the Parkinson's drug Levodopa-Benserazide affects gum health and inflammation. Researchers will measure gum health and saliva markers in 136 people, including Parkinson's patients with and without gum disease, and healthy controls. The goal is to under…

This observational study measures three proteins, PTHrP, RANKL, and OPG, in the fluid that seeps from the gums. Researchers will compare levels in 81 adults split into three groups: healthy gums, gingivitis, and periodontitis. During a routine dental exam, they collect fluid samp…

This study investigates whether chronic gum disease (periodontitis) is linked to changes in the autonomic nervous system — the body's automatic 'wiring' that controls heart rate, digestion, and stress responses. Researchers will measure heart rate variability, a marker of nervous…

This study investigates whether severe gum disease (periodontitis) changes the quality and quantity of a blood-derived material called leukocyte- and platelet-rich fibrin (L-PRF), which is used to help heal gums and bone after dental procedures. Researchers will compare L-PRF sam…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study looks at tissue samples taken from deep gum pockets in people with periodontitis who have already completed initial treatment. Researchers want to describe the tissue features and see if they relate to how well the gums heal. The goal is to better understand healing pa…

This study compares the levels of two bacteria, E. saphenum and P. gingivalis, in 148 adults over age 30—111 with gum disease (periodontitis) and 37 with healthy gums. Researchers collect plaque samples and use advanced lab tests to measure bacterial levels. The goal is to better…

This study looks at whether routine blood sugar testing during dental checkups can help find hidden high blood sugar in people with advanced gum disease. About 300 adults with severe gum disease will get a simple finger-prick blood test during their dental visit. The goal is to s…

This study looks at how smoking changes the body's immune response in gum disease. Researchers compared smokers and non-smokers with healthy gums, gingivitis, or periodontitis. They measured specific proteins and genes in gum tissue to understand the link between smoking and infl…

This study looks at how a standard deep-cleaning procedure called scaling and root planing affects certain proteins in the blood and gum fluid of people with advanced gum disease. Researchers will compare 28 patients with stage 3 periodontitis to 28 healthy individuals, measuring…

This study examines how nicotine buildup in gum tissue influences the results of non-surgical periodontitis treatment. Researchers will measure nicotine and cotinine levels in the gums of 56 smokers and non-smokers with periodontitis. The goal is to understand if nicotine intoxic…

This study looks at how the severity of gum disease (periodontitis) impacts people's daily lives. Researchers examined 300 adults aged 18 to 65, measuring gum health through clinical exams and using two short questionnaires (OHIP-14 and OShip-14) to capture how oral health affect…

This study looks at 50 people with gum disease—25 smokers and 25 non-smokers—to see if a protein in saliva called histatin-1 is linked to healing after standard non-surgical gum treatment. Researchers measure the protein and gum health at the start, one month, and three months af…

This study looks at two genetic markers (Cofilin-2 and Lactoferrin) in 84 adults with gum disease, some of whom also have coronary heart disease. Researchers measure changes in these markers and gum health after a standard deep-cleaning dental treatment. The goal is to better und…

This study follows 30 adults who had surgery for advanced gum disease (periodontitis). Researchers want to see if the surgery keeps teeth healthy and how long the benefits last. Participants are checked at regular visits with exams and X-rays. This is an observational study, mean…