Periodontal disorder

Researchers compare two magnification tools, dental loupes and a dental operating microscope, during non-surgical deep cleaning for stage 3 periodontitis. Thirty adults with the disease receive scaling and root planing on different areas of the mouth, one area cleaned with loupes…

This trial asks whether clear aligners are kinder to gum health than traditional braces during the first three months of orthodontic treatment. Thirty healthy adults with mild crowding will receive either braces or clear aligners, after all participants get a standard teeth clean…

This study tests whether adding injectable platelet-rich fibrin (i-PRF) to a standard bone graft helps fill in bone defects caused by advanced gum disease. Sixteen adults with stage III periodontitis will receive either the combo treatment or the graft alone during surgery. Resea…

This study tests whether placing an implant immediately after extracting a damaged molar, along with a custom-made healing abutment, helps preserve the surrounding gum and bone. Researchers will group participants by the shape of the empty tooth socket and track tissue volume, im…

This study is testing whether a special gel, made from a temperature-sensitive material and loaded with growth factors, can help the jawbone heal and regenerate after impacted wisdom teeth are removed. The gel is liquid when stored cold but turns into a gel at body temperature, d…

This study looks at whether bone grafting right after a molar extraction is necessary or if it can be delayed until the dental implant is placed. Forty adults needing a molar implant will be randomly assigned to get either immediate grafting or delayed grafting. The goal is to se…

This study tests whether a donor tooth-derived bone graft works as well as a patient's own tooth graft for preserving jawbone after impacted wisdom tooth extraction. Forty adults with similar impacted wisdom teeth on both sides of the jaw will receive one graft type per side. Res…

This trial tests whether a gel made from hyaluronic acid and octenidine, placed into deep gum pockets, can improve healing after standard deep cleaning (scaling and root planing) for periodontitis. About 40 adults with moderate to severe gum disease will receive the gel on one si…

This trial tests whether applying a regenerative gel called Emdogain to the root of the second molar during wisdom tooth removal can prevent the deep pockets and bone loss that often develop on that tooth afterward. The study involves 70 healthy adults who need a lower wisdom too…

This study compares two surgical techniques to rebuild lost jawbone in the back of the lower jaw. One method uses the patient's own bone chips with a membrane, while the other uses a special plastic membrane. Sixteen adults with thin jawbones will be treated, and after six months…

This study tests three add-on treatments for gum disease: a platelet-rich fibrin gel (I-PRF), a diode laser, and an iodine rinse. Each is used alongside standard deep cleaning in smokers and non-smokers with moderate to severe periodontitis. The goal is to see which approach best…

This study tests whether taking omega-3 fatty acids (fish oil) plus low-dose aspirin can improve gum disease treatment in smokers with advanced periodontitis. Participants receive these supplements or a placebo alongside standard deep-cleaning procedures. The trial measures chang…

This study tests two types of gum surgery for people with advanced gum disease (periodontitis). One surgery uses a product made from the patient's own blood (PRGF) to help regenerate damaged gum and bone. The other uses a standard animal-derived bone graft and membrane. Researche…

This study tests a new, gentler way to clean deep gum pockets in people with advanced periodontitis. It compares a standard deep-cleaning method using larger tools to a minimally invasive approach using thinner, more delicate instruments. The goal is to see if the gentler method …

This study looks at whether vitamin D levels and supplements can reduce inflammation in people with gum disease (periodontitis or gingivitis). Researchers will measure markers of inflammation in blood and gum fluid before and after treatment. The study involves 120 adults with di…

This early-stage trial tests whether a bone graft material called beta-TCP (Neocement Inject P®) can better preserve the jawbone after a tooth is pulled, compared to letting the socket heal naturally. Thirty adults needing a tooth extraction will be randomly assigned to receive t…

This study tests whether adding a resorbable collagen membrane to a bone graft helps preserve the shape and volume of the jawbone after a tooth is removed. Thirty adults with a missing front tooth and significant bone loss will receive either the bone graft alone or with the memb…

This study tests whether adding special proteins or blood-based membranes to deep cleaning helps repair bone and gum damage from advanced gum disease. 88 adults with deep gum pockets and bone loss will receive one of three treatments or cleaning alone. Researchers will measure bo…

This study is testing whether a special laser device (FX-405) can improve the treatment of gum disease when used along with standard deep cleaning (scaling and root planing). About 70 adults with moderate to severe gum disease will receive eight 10-minute laser sessions over five…

This study compares a test interdental brush to other interdental brushes in 88 adults with active periodontal disease. Over 4 weeks, researchers will measure plaque, gum bleeding, and pocket depth to see which brush works best. Participants use the brush twice daily and report a…

This study is testing whether waiting 4 months instead of the usual 6 months after a tooth extraction is safe and effective for placing a dental implant. Forty adults who need a single tooth replaced will be randomly assigned to either the shorter or standard wait time. Researche…

This study tests a synthetic bone graft material (biphasic calcium sulfate) used during sinus lift surgery to rebuild bone in the upper jaw. The goal is to see if it safely creates enough bone to place dental implants in people who lack sufficient bone due to sinus expansion. For…

This study compares two treatments for deep gum pockets that remain after standard gum disease cleaning. About 36 adults will receive either a growth factor gel (Rh-PDGF) or a tooth protein gel (Emdogain), both combined with bone graft. The goal is to see which better improves gu…

This study compares two treatments to help jawbone heal after a tooth is pulled: the standard platelet-rich fibrin (PRF) made from your own blood, and a newer option using exosomes from stem cells. Exosomes are tiny particles that signal the body to repair tissue and grow bone. R…

This study looks at whether using a small piece of bone from the back of the jaw (maxillary tuberosity) can help rebuild the bone around a dental implant placed immediately after a tooth is pulled in the front of the mouth. Researchers will measure bone thickness, gum thickness, …

This study looks at how well two different bone graft materials preserve the thickness of the front jawbone after a tooth is pulled and an implant is placed right away. About 26 adults who need a front tooth replaced will be randomly assigned to receive one of the two graft types…

This study looks at whether adding a diode laser to standard deep cleaning (scaling and root planing) improves gum disease treatment. Twenty adults with moderate to severe gum disease will have each side of their mouth randomly assigned to cleaning alone or cleaning plus laser. T…

This study tests whether adding a daily probiotic tablet and a coenzyme Q10 toothpaste to standard gum cleaning can improve oral health in pregnant women. Forty pregnant women will be split into two groups: one gets the probiotic plus Q10 toothpaste, the other gets only the Q10 t…

This study tests whether a gel containing lovastatin, a cholesterol drug, can improve standard gum disease treatment. Researchers will compare the medicated gel to a placebo gel in 44 adults with periodontitis, including both smokers and non-smokers. The goal is to see if the gel…

This study compares two methods of rebuilding jawbone in people who have lost bone and need dental implants. One method uses the patient's own bone, and the other uses donated (allogeneic) bone. The goal is to see if both approaches are equally safe and effective at restoring eno…

This study tests a new surgical method for treating advanced gum disease. Instead of removing all inflamed tissue, the surgeon preserves the granulation tissue (the body's natural healing tissue) to see if it leads to better gum attachment and less bleeding. The trial involves 50…

This study tests a new surgical technique called NIPSA, combined with a gum graft and special proteins, to treat severe gum disease. Forty adults with periodontitis and deep gum pockets will receive the procedure. The goal is to see if this approach can reduce pocket depth and im…

This study compares three different surgical methods to treat gum disease (periodontitis). The goal is to see which technique best reduces deep gum pockets and helps gums reattach to teeth. About 60 adults with gum disease will be randomly assigned to one of the three procedures.…

This study tests if a probiotic spray containing good bacteria can help prevent and treat gum disease in older adults. Researchers will give 90 elderly participants either the probiotic spray or a placebo for four weeks. They will measure changes in gum health, bleeding, and bad …

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This study tests whether using a toothpaste with sodium bicarbonate (baking soda) and fluoride can help maintain gum health in adults who have already had non-surgical gum treatment. One hundred participants will use either the special toothpaste or a placebo for six months, whil…

This study tests whether a gel made from a patient's own blood can improve gum healing after standard deep cleaning for moderate to severe gum disease. About 14 adults with gum pockets of 5mm or deeper will receive the blood gel on one side of the mouth and a saltwater rinse on t…

This study tests whether a special dental gel (Livfresh) can improve gum health when used alongside standard deep cleaning. About 76 adults with moderate gum disease will brush with the gel twice daily for 6 months. Researchers will measure changes in gum pocket depth and bleedin…

This study tests whether a hydrogen peroxide mouth rinse (OROXID®) can improve gum health when used alongside standard dental cleaning. About 90 adults with moderate-to-severe gum disease will use either a 1.5% or 3% rinse or a control rinse for 12 weeks. The goal is to see if it…

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as well as a dentist. Participants will have their gums and blood suga…

This study tests two materials used to fill bone defects caused by gum disease: a collagen matrix and a bovine bone mineral. 80 adults with advanced periodontitis will receive one of the two during surgery. Researchers will measure changes in gum attachment and other healing sign…

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing whether a simple online questionnaire can accurately assess a person's risk for gum disease (periodontitis or gingivitis). About 393 adults in Saudi Arabia will fill out the questionnaire and then have a dental exam to compare results. The goal is to see if …

This study is testing whether simpler methods like mouth photos, dental X-rays, saliva tests, and questionnaires can accurately detect gum disease (gingivitis and periodontitis) compared to a standard full-mouth exam. About 2,000 adults from five centers will participate. The goa…

This study tests whether chewing xylitol gum during pregnancy can reduce the risk of preterm birth and low birthweight. 6,000 pregnant women in Malawi will chew either a high or low dose of xylitol gum or a placebo gum. The goal is to see if improving oral health with xylitol lea…

This study tests whether using a lactoferrin-based toothpaste and mouthwash twice daily, along with regular professional cleanings, can prevent gum disease in pregnant women. Forty pregnant women in their second trimester will be split into two groups: one using both the toothpas…

This study tests whether toothbrushes with tapered bristles are better at removing plaque and reducing gum bleeding than regular round bristles, without causing scratches. About 70 adults with gum disease will use one of two toothbrushes at home for 4 weeks. Researchers will chec…

This study compares two types of stitches (NOVOSYN quick and MONOSYN quick) used in gum surgery to see if they heal equally well. About 84 adults having gum surgery will be randomly assigned one of the two stitches. The main goal is to check early healing signs like skin regrowth…

This study compares a new mousse (microRepair ABX) to a standard mouthwash for healing after tooth extraction. About 30 adults who need a tooth pulled will use one of the two treatments. Researchers will check pain, swelling, and healing at 1, 7, and 15 days after surgery to see …

This study tests whether applying low-level laser light to the gums after tooth extraction and socket preservation can improve healing and reduce pain. About 39 adults will receive either standard care or standard care plus laser treatment on days 1, 3, and 7 after surgery. Resea…

This study tests whether using a microscope during gum surgery leads to better healing than standard dental loupes (magnifying glasses). About 25 adults with gum disease will take part. Researchers will check how well the gums heal and how long the stitching takes.

This study looks at how genetic immune system problems might lead to gum disease and other mouth issues. Researchers will collect samples like saliva, plaque, and blood from 700 people, including those with immune defects, healthy adults with gum disease, and healthy adults witho…

This study looks at how gum surgery changes inflammation markers in the blood. Researchers will take blood samples from 30 adults before, during, and after dental procedures. The goal is to see if surgical stress causes a different inflammatory response compared to non-surgical c…

This study is testing a new type of dental MRI (ddMRI) to see if it can work as well as standard dental X-rays for diagnosing problems like crowded teeth, jaw pain, and infections. About 300 adults will get a ddMRI scan and then compare the results to their regular dental images.…

This study looks at whether certain substances in spit and fluid around dental implants can help detect a gum disease called peri-implantitis early. Researchers will compare 80 people with healthy gums, regular gum disease, or implant-related gum disease. The goal is to find bett…

This study looks at how fixed versus removable orthodontic retainers influence the types of bacteria living in the gum pockets and overall gum health. Ten adults who have finished braces will be split into two groups: one gets a fixed retainer bonded to the back of the teeth, the…

This study examines a possible connection between gum disease and chronic neck pain. Researchers will compare neck pain intensity and daily disability among adults aged 30-55 with healthy gums, gingivitis, or periodontitis. Participants complete pain scales and questionnaires to …

This study looks at how common and severe gum disease is in people with obesity. Researchers will check dental health, analyze saliva for signs of inflammation, and look at genes linked to obesity. They will also study the bacteria in dental plaque to understand the connection be…

This pilot study investigates how a gel made from hyaluronic acid and polynucleotides affects early healing of gum defects after surgery. Researchers will measure molecular markers in gum fluid and use laser imaging to track blood flow changes. The study includes 24 adults with a…

This study looks at how the types of bacteria in the mouth change in people with severe gum disease as they go from having some teeth left to having no teeth, and then after getting dental implants. Researchers will collect microbial samples and analyze DNA to see if different im…

This study follows 100 adults with healthy gums or various stages of gum disease over two years. Researchers will collect saliva and plaque samples at yearly visits to measure specific biomarkers. The goal is to see if these markers can predict who will develop or worsen gum dise…

This study looks at gum disease in people with rare kidney disorders like Alport syndrome, Fabry disease, and tuberous sclerosis, as well as lupus. Researchers will compare 100 participants to those with chronic kidney disease and healthy controls. They aim to understand how comm…

This study looks at whether high uric acid levels (hyperuricemia) are linked to more severe gum disease and bone loss. Researchers will measure inflammation and oxidative stress markers in gum fluid and blood from 80 adults. Participants are grouped by gum health and uric acid st…

This study looks at whether certain proteins in saliva can signal the start of gum disease. Researchers will collect saliva from 240 adults with healthy gums, gingivitis, or periodontitis and measure specific biomarkers linked to bone loss. The goal is to find a simple, non-invas…

This study surveys 100 general practitioners in Italy to assess their knowledge of how oral health, especially gum disease, relates to systemic conditions like diabetes. Participants complete a 35-question digital questionnaire. The goal is to identify gaps in knowledge and impro…

This study looks at whether gum disease is more common in people who have had a heart attack. Researchers will compare the gum health of 320 adults—some who recently had a heart attack and some who haven't—to see if there's a link. The goal is to gather information that could lea…

This study is checking how often the fungus Candida albicans shows up in the gums of 100 Syrian adults with periodontitis (serious gum disease). Researchers will collect plaque samples and measure gum health to see if the fungus is linked to more severe disease. The goal is to be…

This study checks how often two tiny parasites (Entamoeba gingivalis and Trichomonas tenax) are found in the mouths of people with and without gum disease. Researchers will collect spit and plaque samples from 120 adults and look at them under a microscope. The goal is to learn i…

This study looks at how antibiotics like amoxicillin and metronidazole work in the body when used with deep cleaning for severe gum disease. Researchers want to find the best dose and treatment length (3 vs 7 days) to kill harmful bacteria without overusing antibiotics. About 45 …

This study looks at whether bacteria in your mouth can influence the buildup of fatty plaques in the neck arteries that supply blood to the brain. Researchers will collect samples from 200 adults having surgery to remove these plaques and compare the bacteria found in the mouth, …

This observational study at the University of Chile is examining whether a specific immune pathway (JAK1/2) is overactive in people with periodontitis, a common gum disease. Researchers will compare gum tissue from 30 healthy adults and those with inflamed gums to measure pathway…

This study looks back at 130 patients who had upper back teeth removed. Some had their tooth socket filled with bone graft material to preserve the jawbone, while others healed naturally. Researchers will compare CT scans taken months later to see if the preserved group has more …

This study looks at how standard gum disease treatments—deep cleaning with or without a special mouthwash—change proteins in your saliva and affect blood vessel health. Researchers will study 30 adults with gum disease to see if these treatments help or harm the good bacteria tha…

This study looks at whether sleep quality is linked to gum disease (periodontitis). Researchers will measure sleep quality, fatigue, and certain substances in saliva from 48 healthy adults with or without gum disease. The goal is to better understand how oral health and sleep are…

This study looks at how the severity of pemphigus vulgaris, a chronic autoimmune skin disease, relates to gum health. Researchers will examine 20 adults with confirmed PV, measuring mouth sores and gum pocket depth, and comparing these with blood antibody levels. The goal is to u…

This study looks at how gum disease and smoking change certain proteins in saliva. Researchers will collect saliva and check gum health in 116 people with and without periodontitis. The goal is to see if these proteins can help diagnose gum disease and understand smoking's role.

This study is looking at whether certain markers in blood and saliva can predict how well people with gum disease heal after non-surgical treatment. Researchers will measure these markers in 180 adults with healthy gums, gingivitis, or advanced periodontitis before and after trea…

This study looks at a protein called Mitofusin-1 in saliva to see if it can help measure how severe gum disease is and how well treatment works. Researchers will compare healthy people, those with mild to severe gum disease, and smokers with severe gum disease. Participants give …

This observational study in 46 people with severe gum disease aims to understand how two types of gum tissue (infra-osseous and supra-osseous granulation tissue) differ in their healing potential and infection-fighting properties. Researchers will collect tissue samples during pe…

This study looks at whether training medical staff and using electronic health records can encourage older adults (55+) on Medicaid to visit the dentist more often. About 929 participants from 12 primary care clinics will be split into two groups: one where doctors get extra trai…