Could a Patient's own blood regrow gum and bone better than animal grafts?
NCT ID NCT04254861
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This study tests two types of gum surgery for people with advanced gum disease (periodontitis). One surgery uses a product made from the patient's own blood (PRGF) to help regenerate damaged gum and bone. The other uses a standard animal-derived bone graft and membrane. Researchers will compare how well each method reduces deep gum pockets and promotes bone regrowth over 12 months.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PRGF (platelet-rich growth factor from patient's own blood)
- What this could lead to
- If PRGF works as well as or better than the standard bone graft, it could offer a simpler, natural alternative for regenerating gum and bone tissue damaged by periodontitis.
- What could go wrong
- This is a small, early-stage study (74 people) comparing two surgical techniques. PRGF is still experimental for this use, and results may not apply to all patients or guarantee long-term success.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 74 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2021
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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25 to 80 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Systemically healthy males and females ≥25 years old * Willingness to read and sign a copy of the Informed Consent Form after reading the Patient Information Sheet, and after the nature of the study has been fully explained * Clinical evidence of periodontitis, with one interdental area of PPD ≥6mm, BOP, and attachment loss ≥6mm, with associated intrabony defect ≥3mm in any area of their mouth (excluding third molars and distal of second molars) * Full mouth bleeding and plaque scores (FMBS and FMPS) \<25%recorded within the previous 6 weeks * Non-surgical treatment completed within 6 months prior to assessment for eligibility Exclusion Criteria: * Medical history that includes diabetes type 1 or hepatic or renal disease, or other serious medical conditions or transmittable diseases (e.g. cardiovascular disease or AIDS). * Antibiotic or anti-inflammatory therapy during the month preceding the baseline exam. * In chronic treatment (\>2 weeks) with anticoagulants, corticosteroids or other medications that can severely impact on bone formation * History of alcohol or drug abuse. * Smoking ≥10 cigarettes a day * Self-reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing, which can affect interpretation of study results). * Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or investigational product administration or may interfere with the interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial. * Periodontal surgery in the same area selected for the study within the past 12 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Barts and The London Dental Hospital
RECRUITINGLondon, E1 2AD, United Kingdom
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