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Could a collagen wrap save your jawbone for better dental implants?

NCT ID NCT07580495

Disease control Sponsor: Debora Dias Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a resorbable collagen membrane to a bone graft helps preserve the shape and volume of the jawbone after a tooth is removed. Thirty adults with a missing front tooth and significant bone loss will receive either the bone graft alone or with the membrane. After about 4 months, scans will measure bone changes to see if the membrane improves outcomes for future dental implant placement.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
resorbable collagen membrane (InterCollagen® Guide) and anorganic bone-collagen composite (ABCC, SigmaGraft®)
What this could lead to
If it works, this could improve the success of dental implants by maintaining jawbone shape after tooth extraction, reducing the need for additional bone grafting.
What could go wrong
This is a small, early-stage trial with only 30 participants, so results may not apply to everyone. The collagen membrane may not provide significant benefit over the bone graft alone, and there are risks like infection or poor healing.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-80 * Indicated for extraction of a single-rooted maxillary tooth * ≥ 50% buccal bone dehiscence confirmed by CBCT reconstructions * Presence of both adjacent teeth * No interproximal bone loss * ASA I-II health status * Ability to comply with required procedures, including attending required number of clinic visits Exclusion Criteria: * Patients diagnosed with periodontitis adjacent to the area to be treated * History of allergic reactions to local anesthetics or bone graft material (self-reported); * Current heavy smokers (≥ 10 cigarettes/day) or those who quit smoking recently (self-reported; last 6 months); * Diagnosis of diabetes mellitus, liver or kidney failure (self-reported); * Presence of active infectious diseases of any kind; * History of chemotherapy or radiation therapy to the head or neck within the past 5 years (self-reported); * Severe hematologic disorders (risk for hemorrhage)(self-reported); * Assumption of corticosteroids, IV bisphosphonates or immunosuppressive drugs; * Any history of alcohol or drug abuse (self-reported); * Pregnancy or plans to become pregnant within 4 months of study enrollment (self-reported);

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone loss Dehiscence Tooth extraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Pittsburgh School of Dental Medicine, Department of Periodontics and Preventive Dentistry

    RECRUITING

    Pittsburgh, Pennsylvania, 15213, United States

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