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Can stem cell particles help your jawbone heal stronger after a tooth pull?

NCT ID NCT07508033

Disease control Sponsor: Al Salam University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two treatments to help jawbone heal after a tooth is pulled: the standard platelet-rich fibrin (PRF) made from your own blood, and a newer option using exosomes from stem cells. Exosomes are tiny particles that signal the body to repair tissue and grow bone. Researchers will measure bone density and shape with 3D X-rays three months after treatment in 40 adults aged 20–45.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
stem cell exosomes
What this could lead to
If it works, this could offer a better way to preserve jawbone after tooth extraction, making future dental implants easier and more successful.
What could go wrong
This is an early Phase 1/2 trial with only 40 people, so results may not apply widely. Exosomes are experimental and their long-term safety and effectiveness are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Aug 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 20 and 45 years. * Patients requiring a single tooth extraction of a non-infected tooth in the aesthetic zone (incisors, canines) or premolar area. * Presence of adjacent teeth to the extraction site. * Adequate oral hygiene (Plaque Index \< 20%). * Patients willing and able to comply with the follow-up schedule and 3-month CBCT scan. * Signed informed consent provided by the participant. Exclusion Criteria: * Patients with systemic diseases that contraindicate oral surgery or interfere with bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism). * History of head and neck radiation therapy or bisphosphonate medication use. * Active infection or acute abscess at the extraction site. * Heavy smokers (more than 10 cigarettes per day). * Pregnant or lactating women. * Patients with poor oral hygiene or active periodontal disease in the rest of the mouth. * Use of any medications known to affect bone metabolism (e.g., long-term corticosteroids).

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Conditions

The condition(s) this trial relates to.

Alveolar Bone Loss periodontal disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolar bone loss Bone regeneration Tooth extraction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Department of Oral & Maxillofacial Surgery, Al Salam University

    RECRUITING

    Tanta, Gharbia Governorate, Egypt

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