Nervous system disorder
MONDO:0005071A non-neoplastic or neoplastic disorder that affects the brain, spinal cord, or peripheral nerves.
Also known as: disease of nervous system, disease or disorder of nervous system, disorder of nervous system, nervous system disease, nervous system disease or disorder, nervous system disorder, neurologic disease, neurologic disorder
26588 clinical trials for this condition and its sub-types, 245 tagged with Nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Nervous system disorder
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Central nervous system disorder 119 trials · 20,397 incl. sub-types
19 sub-types
- Brain disorder 136 trials · 16,663 incl. sub-types Sub-types →
- Neurodegenerative disease 186 trials · 3,277 incl. sub-types Sub-types →
- Central nervous system neoplasm 51 trials · 1,979 incl. sub-types Sub-types →
- Spinal cord disorder 46 trials · 1,251 incl. sub-types Sub-types →
- Autoimmune disorder of central nervous system 2 trials · 874 incl. sub-types Sub-types →
- Palsy 36 trials · 843 incl. sub-types Sub-types →
- Encephalomyelitis 3 trials · 226 incl. sub-types Sub-types →
- Autonomic nervous system disorder 59 trials · 209 incl. sub-types Sub-types →
- Central nervous system infectious disorder 10 trials · 163 incl. sub-types Sub-types →
- Optic nerve disorder 23 trials · 95 incl. sub-types Sub-types →
- Tinnitus 90 trials
- Central nervous system vasculitis 3 trials · 55 incl. sub-types Sub-types →
- Trigeminal neuralgia 37 trials
- Cerebrospinal fluid leak 16 trials · 17 incl. sub-types Sub-types →
- High pressure neurological syndrome 0 trials · 5 incl. sub-types Sub-types →
- SPAST-related motor disorder 0 trials · 2 incl. sub-types Sub-types →
- Congenital narrowing of cervical spinal canal 0 trials
- Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly 0 trials
- Sporadic fetal brain disruption sequence 0 trials Sub-types →
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Hereditary neurological disease 6 trials · 5,772 incl. sub-types
264 sub-types
- Parkinson disease 1,165 trials · 1,292 incl. sub-types Sub-types →
- Anxiety 1,030 trials
- Hereditary neuromuscular disease 3 trials · 932 incl. sub-types Sub-types →
- Inherited neurodegenerative disorder 10 trials · 807 incl. sub-types Sub-types →
- Inherited retinal dystrophy 41 trials · 510 incl. sub-types Sub-types →
- Mendelian neurodevelopmental disorder 0 trials · 207 incl. sub-types Sub-types →
- Obsessive-compulsive disorder 196 trials
- Hereditary ataxia 2 trials · 119 incl. sub-types Sub-types →
- Essential tremor 102 trials · 104 incl. sub-types Sub-types →
- Neurofibromatosis 19 trials · 94 incl. sub-types Sub-types →
- Myalgic encephalomeyelitis/chronic fatigue syndrome 73 trials
- Inherited orthostatic hypotension 0 trials · 71 incl. sub-types Sub-types →
- Nonsyndromic genetic hearing loss 4 trials · 67 incl. sub-types Sub-types →
- Inherited vitreoretinopathy 0 trials · 58 incl. sub-types Sub-types →
- Paraganglioma 53 trials · 57 incl. sub-types Sub-types →
- Retinal detachment 28 trials · 52 incl. sub-types Sub-types →
- Tuberous sclerosis 41 trials · 44 incl. sub-types Sub-types →
- Combined pituitary hormone deficiencies, genetic form 1 trial · 42 incl. sub-types Sub-types →
- Endogenous depression 42 trials
- Specific phobia 22 trials · 42 incl. sub-types Sub-types →
- Tourette syndrome 41 trials
- Familial partial epilepsy 0 trials · 39 incl. sub-types Sub-types →
- Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types Sub-types →
- Inherited dystonia 0 trials · 36 incl. sub-types Sub-types →
- Normal pressure hydrocephalus 35 trials
- Mismatch repair cancer syndrome 1 34 trials
- Hereditary generalized epilepsy 0 trials · 33 incl. sub-types Sub-types →
- X-linked deafness 0 trials · 32 incl. sub-types Sub-types →
- Familial isolated pituitary adenoma 1 trial · 31 incl. sub-types Sub-types →
- Von Hippel-Lindau disease 27 trials
- Specific language impairment 26 trials Sub-types →
- Stutter disorder 22 trials Sub-types →
- Moyamoya disease 20 trials Sub-types →
- Angelman syndrome 19 trials Sub-types →
- Cerebral amyloid angiopathy 16 trials · 17 incl. sub-types Sub-types →
- Li-Fraumeni syndrome 16 trials
- Childhood apraxia of speech 16 trials
- Intracranial berry aneurysm 12 trials Sub-types →
- Progressive myoclonus epilepsy 5 trials · 12 incl. sub-types Sub-types →
- DiGeorge syndrome 11 trials
- Auditory neuropathy 7 trials · 11 incl. sub-types Sub-types →
- Major affective disorder 6 11 trials
- Spastic quadriplegic cerebral palsy 10 trials Sub-types →
- Chiari malformation type I 9 trials
- Neurohypophyseal diabetes insipidus 9 trials
- Sturge-Weber syndrome 8 trials
- Progressive external ophthalmoplegia 4 trials · 8 incl. sub-types Sub-types →
- Qualitative or quantitative defects of protein involved in O-glycosylation of alpha-dystroglycan 0 trials · 8 incl. sub-types Sub-types →
- Red-green color blindness 7 trials
- Duane retraction syndrome 6 trials Sub-types →
- Arthrogryposis 4 trials · 6 incl. sub-types Sub-types →
- Inborn aminoacylase deficiency 0 trials · 6 incl. sub-types Sub-types →
- Undetermined early-onset epileptic encephalopathy 1 trial · 6 incl. sub-types Sub-types →
- GLUT1 deficiency syndrome 4 trials · 5 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Congenital nystagmus 4 trials · 5 incl. sub-types Sub-types →
- Congenital stationary night blindness 2 trials · 5 incl. sub-types Sub-types →
- Narcolepsy 1 5 trials
- Nevoid basal cell carcinoma syndrome 5 trials Sub-types →
- Qualitative or quantitative defects of beta-sarcoglycan 0 trials · 5 incl. sub-types Sub-types →
- TTN-related myopathy 2 trials · 4 incl. sub-types Sub-types →
- Corpus callosum, agenesis of 4 trials Sub-types →
- Glutaryl-CoA dehydrogenase deficiency 4 trials
- Qualitative or quantitative defects of gamma-sarcoglycan 1 trial · 4 incl. sub-types Sub-types →
- Velocardiofacial syndrome 4 trials
- Hoyeraal-Hreidarsson syndrome 3 trials
- Riley-Day syndrome 3 trials
- TPM2-related myopathy 1 trial · 3 incl. sub-types Sub-types →
- Bilirubin encephalopathy 3 trials Sub-types →
- Congenital hydrocephalus 1 trial · 3 incl. sub-types Sub-types →
- Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types Sub-types →
- Familial congenital mirror movements 3 trials Sub-types →
- Familial porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Inherited reflex epilepsy 0 trials · 3 incl. sub-types Sub-types →
- Megalencephaly-capillary malformation-polymicrogyria syndrome 3 trials
- Neuromuscular disease caused by qualitative or quantitative defects of dysferlin 0 trials · 3 incl. sub-types Sub-types →
- Pontocerebellar hypoplasia 1 trial · 3 incl. sub-types Sub-types →
- Pyridoxine-dependent epilepsy 3 trials Sub-types →
- Qualitative or quantitative defects of alpha-sarcoglycan 0 trials · 3 incl. sub-types Sub-types →
- ATP1A3-associated neurological disorder 0 trials · 2 incl. sub-types Sub-types →
- Chiari malformation type II 2 trials
- PAX6-related ocular dysgenesis 0 trials · 2 incl. sub-types Sub-types →
- SPAST-related motor disorder 0 trials · 2 incl. sub-types Sub-types →
- Central nervous system lupus 2 trials
- Childhood-onset nemaline myopathy 1 trial · 2 incl. sub-types Sub-types →
- Choroid plexus papilloma 2 trials
- Dyskinesia with orofacial involvement, autosomal dominant 2 trials
- Hereditary retinoblastoma 2 trials
- Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome 2 trials
- Isolated hereditary congenital facial paralysis 2 trials Sub-types →
- Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types Sub-types →
- Pyridoxal phosphate-responsive seizures 2 trials
- Qualitative or quantitative defects of delta-sarcoglycan 0 trials · 2 incl. sub-types Sub-types →
- Retinal ciliopathy 0 trials · 2 incl. sub-types Sub-types →
- 2-hydroxyglutaric aciduria 0 trials · 1 incl. sub-types Sub-types →
- Brown syndrome 1 trial
- Gerstmann-Straussler-Scheinker syndrome 1 trial
- Guillain-Barre syndrome, familial 1 trial
- PRRT2-associated paroxysmal movement disorder 0 trials · 1 incl. sub-types Sub-types →
- TH-deficient dopa-responsive dystonia 1 trial
- TPM3-related myopathy 1 trial Sub-types →
- Anencephaly 1 trial Sub-types →
- Bilateral striopallidodentate calcinosis 1 trial Sub-types →
- Biotin-responsive basal ganglia disease 1 trial
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder 1 trial
- Coloboma of optic nerve 1 trial Sub-types →
- Dilated cardiomyopathy 3B 1 trial
- Epilepsy with myoclonic atonic seizures 1 trial
- Familial hemiplegic migraine 0 trials · 1 incl. sub-types Sub-types →
- Familial meningioma 1 trial
- Familial periodic paralysis 0 trials · 1 incl. sub-types Sub-types →
- Familial pterygium of the conjunctiva 1 trial
- Famililal cerebral cavernous malformations 1 trial Sub-types →
- Iris hypoplasia with glaucoma 1 trial
- Isolated cerebellar hypoplasia/agenesis 1 trial
- Linear nevus sebaceous syndrome 1 trial
- Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome 1 trial
- Multiminicore myopathy 1 trial Sub-types →
- Myoclonus, familial 1 trial Sub-types →
- Myopathy caused by variation in POMGNT1 0 trials · 1 incl. sub-types Sub-types →
- Neurocutaneous melanocytosis 1 trial
- Neuromuscular disease caused by qualitative or quantitative defects of plectin 0 trials · 1 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of telethonin 0 trials · 1 incl. sub-types Sub-types →
- Qualitative or quantitative defects of desmin 0 trials · 1 incl. sub-types Sub-types →
- Rhabdoid tumor predisposition syndrome 2 1 trial
- Rolandic epilepsy, intellectual disability, and speech dyspraxia, X-linked 1 trial
- Severe congenital nemaline myopathy 0 trials · 1 incl. sub-types Sub-types →
- B4GALT1-congenital disorder of glycosylation 0 trials
- Bailey-Bloch congenital myopathy 0 trials
- Behr syndrome 0 trials
- Behrens Baumann dust syndrome 0 trials
- Brody myopathy 0 trials
- DHDDS-related syndrome 0 trials Sub-types →
- Frey syndrome 0 trials
- Griscelli syndrome type 1 0 trials
- HSD10 mitochondrial disease 0 trials Sub-types →
- Johanson-Blizzard syndrome 0 trials
- KIF5A-related neurological disorder 0 trials Sub-types →
- LSM7-related leukodystrophy and cerebellar atrophy 0 trials
- Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome 0 trials
- NPHP3-related Meckel-like syndrome 0 trials
- PEHO-like syndrome 0 trials
- PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome 0 trials
- PrP systemic amyloidosis 0 trials
- Prader-Willi-like syndrome 0 trials Sub-types →
- Ritscher-Schinzel syndrome 0 trials Sub-types →
- SERAC1-related neurological disorder 0 trials Sub-types →
- SLC39A8-CDG 0 trials
- SLC6A3-related dopamine transporter deficiency syndrome 0 trials Sub-types →
- TELO2-related intellectual disability-neurodevelopmental disorder 0 trials
- TUBB3-related tubulinopathy 0 trials Sub-types →
- Uner Tan Syndrome 0 trials
- VPS11-related neurological disorder 0 trials Sub-types →
- Valence-Farazi cerebellar ataxia syndrome 0 trials
- X-linked immunoneurologic disorder 0 trials
- X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome 0 trials
- Achromatopsia 6 0 trials
- Adult-onset nemaline myopathy 0 trials
- Age-related hearing impairment 1 0 trials
- Age-related hearing impairment 2 0 trials
- Alpha-actinopathy 0 trials Sub-types →
- Angioid streaks 0 trials Sub-types →
- Aniridia 2 0 trials
- Aniridia 3 0 trials
- Ataxia - intellectual disability - oculomotor apraxia - cerebellar cysts syndrome 0 trials
- Band heterotopia of brain 0 trials
- Benign familial infantile epilepsy 0 trials Sub-types →
- Benign neonatal seizures 0 trials Sub-types →
- Bilateral frontoparietal polymicrogyria 0 trials
- Bilateral generalized polymicrogyria 0 trials
- Bilateral parasagittal parieto-occipital polymicrogyria 0 trials
- Blue color blindness 0 trials
- Bradyopsia 0 trials Sub-types →
- Brain malformations with or without urinary tract defects 0 trials
- Brain-lung-thyroid syndrome 0 trials
- Cathepsin a-related arteriopathy-strokes-leukoencephalopathy 0 trials
- Caveolinopathy 0 trials Sub-types →
- Cerebellar-facial-dental syndrome 0 trials
- Chorea, remitting, with nystagmus and cataract 0 trials
- Choreoathetosis, familial inverted 0 trials
- Cirrhosis - dystonia - polycythemia - hypermanganesemia syndrome 0 trials
- Cluster headache, familial 0 trials
- Complex cortical dysplasia with other brain malformations 0 trials Sub-types →
- Congenital insensitivity to pain with severe intellectual disability 0 trials
- Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome 0 trials
- Dystonia, dopa-responsive, with or without hyperphenylalaninemia, autosomal recessive 0 trials
- Encephalopathy due to mitochondrial and peroxisomal fission defect 0 trials Sub-types →
- Encephalopathy, acute transient 0 trials
- Encephalopathy, recurrent, of childhood 0 trials
- Epilepsy, X-linked, with or without impaired intellectual development and dysmorphic features 0 trials Sub-types →
- Epilepsy, familial adult myoclonic 0 trials Sub-types →
- Familial Alzheimer-like prion disease 0 trials
- Familial congenital palsy of trochlear nerve 0 trials
- Familial hemophagocytic lymphohistiocytosis type 1 0 trials
- Familial hyperprolactinemia 0 trials
- Familial infantile myoclonic epilepsy 0 trials
- Familial panic disorder 0 trials Sub-types →
- Familial retinal arterial macroaneurysm 0 trials
- Familial schizencephaly 0 trials
- Familial syringomyelia 0 trials
- Fatty acyl-CoA reductase 1 upregulation 0 trials
- Febrile seizures, familial, 11 0 trials
- Folinic acid-responsive seizures 0 trials
- Glycine encephalopathy 0 trials Sub-types →
- Hereditary hyperekplexia 0 trials Sub-types →
- Hereditary progressive chorea without dementia 0 trials
- Holoprosencephaly 0 trials Sub-types →
- Hyperlexia 0 trials
- Hypermanganesemia with dystonia 2 0 trials
- Infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly 0 trials
- Infection-induced acute-onset axonal neuropathy 0 trials
- Intracranial extraskeletal myxoid chondrosarcoma 0 trials
- Lateral meningocele syndrome 0 trials
- Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome 0 trials
- Lissencephaly spectrum disorders 0 trials Sub-types →
- Macrocephaly/megalencephaly syndrome, autosomal recessive 0 trials
- Major affective disorder 1 0 trials
- Major affective disorder 2 0 trials
- Major affective disorder 3 0 trials
- Major affective disorder 4 0 trials
- Major affective disorder 5 0 trials
- Major affective disorder 7 0 trials
- Major affective disorder 8 0 trials
- Major affective disorder 9 0 trials
- Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome 0 trials Sub-types →
- Melanoma and neural system tumor syndrome 0 trials
- Microangiopathy and leukoencephalopathy, pontine, autosomal dominant 0 trials
- Microcephaly-complex motor and sensory axonal neuropathy syndrome 0 trials
- Multiple pterygium-malignant hyperthermia syndrome 0 trials
- Myofibrillar myopathy 5 0 trials
- Myopathy due to calsequestrin and SERCA1 protein overload 0 trials
- Myopic macular degeneration 0 trials
- Myosclerosis 0 trials
- Narcolepsy 3 0 trials
- Narcolepsy 7 0 trials
- Neuromuscular disease caused by qualitative or quantitative defects of TRIM32 0 trials Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of beta-myosin heavy chain (MYH7) 0 trials Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of perlecan 0 trials Sub-types →
- Neuroocular syndrome 0 trials Sub-types →
- Occipital pachygyria and polymicrogyria 0 trials
- Oculocerebrocutaneous syndrome 0 trials
- Orofaciodigital syndrome type 6 0 trials
- Parietal foramina 0 trials Sub-types →
- Parkinsonism with polyneuropathy 0 trials
- Paroxysmal extreme pain disorder 0 trials
- Periventricular nodular heterotopia 0 trials Sub-types →
- Permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome 0 trials
- Phakomatosis pigmentokeratotica 0 trials
- Polyhydramnios, megalencephaly, and symptomatic epilepsy 0 trials
- Polymicrogyria, bilateral perisylvian, autosomal recessive 0 trials
- Polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis 0 trials
- Progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome 0 trials
- Prosopagnosia, hereditary 0 trials
- Proximal myopathy with extrapyramidal signs 0 trials
- Red color blindness 0 trials
- Rolandic epilepsy-paroxysmal exercise-induced dystonia-writer's cramp syndrome 0 trials
- Sacral agenesis-abnormal ossification of the vertebral bodies-persistent notochordal canal syndrome 0 trials
- Schizophrenia 15 0 trials
- Schizophrenia 16 0 trials
- Schizophrenia 19 0 trials
- Severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome 0 trials
- Severe neonatal-onset encephalopathy with microcephaly 0 trials
- Spongiform encephalopathy with neuropsychiatric features 0 trials
- Typical nemaline myopathy 0 trials Sub-types →
-
Neurovascular disorder 5 trials · 4,196 incl. sub-types
29 sub-types
- Cerebrovascular disorder 107 trials · 3,282 incl. sub-types Sub-types →
- Migraine disorder 390 trials · 411 incl. sub-types Sub-types →
- Retinal vascular disorder 9 trials · 324 incl. sub-types Sub-types →
- Intracranial hypertension 51 trials · 97 incl. sub-types Sub-types →
- Central nervous system vasculitis 3 trials · 55 incl. sub-types Sub-types →
- Trigeminal autonomic cephalalgia 8 trials · 27 incl. sub-types Sub-types →
- Choroid plexus cancer 0 trials · 11 incl. sub-types Sub-types →
- Choroid cancer 0 trials · 10 incl. sub-types Sub-types →
- Hemangioblastoma 9 trials · 10 incl. sub-types Sub-types →
- Lymphatic malformation 5 8 trials
- Choroideremia 6 trials Sub-types →
- Ornithine aminotransferase deficiency 4 trials
- Benign choroid plexus neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Cavernous sinus meningioma 2 trials
- Central nervous system hemangioma 0 trials · 2 incl. sub-types Sub-types →
- Hemangioma of retina 0 trials · 1 incl. sub-types Sub-types →
- Retinal ischemia 1 trial
- Norman-Roberts syndrome 0 trials
- Wyburn-Mason syndrome 0 trials
- Benign neoplasm of choroid 0 trials Sub-types →
- Central nervous system angiosarcoma 0 trials
- Choroidal dystrophy, central areolar 2 0 trials
- Choroidal dystrophy, central areolar, 1 0 trials
- Choroidal sclerosis 0 trials Sub-types →
- Eyelid capillary hemangioma 0 trials
- Malignant jugulotympanic paraganglioma 0 trials
- Microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability 0 trials
- Neoplasm of aortic body 0 trials
- Retinal dystrophies primarily involving Bruch's membrane 0 trials Sub-types →
-
Nervous system neoplasm 8 trials · 2,580 incl. sub-types
7 sub-types
- Nervous system cancer 17 trials · 1,996 incl. sub-types Sub-types →
- Central nervous system neoplasm 51 trials · 1,979 incl. sub-types Sub-types →
- Neuroepithelial neoplasm 6 trials · 1,339 incl. sub-types Sub-types →
- Peripheral nervous system neoplasm 3 trials · 196 incl. sub-types Sub-types →
- Tumor of cranial and spinal nerves 0 trials · 129 incl. sub-types Sub-types →
- Nervous system benign neoplasm 0 trials · 87 incl. sub-types Sub-types →
- Retina neoplasm 2 trials · 36 incl. sub-types Sub-types →
-
Perceptual disorders 22 trials · 2,382 incl. sub-types
9 sub-types
- Agnosia 837 trials · 855 incl. sub-types Sub-types →
- Hearing disorder 24 trials · 529 incl. sub-types Sub-types →
- Inherited retinal dystrophy 41 trials · 510 incl. sub-types Sub-types →
- Vision disorder 105 trials · 382 incl. sub-types Sub-types →
- Vestibular disorder 64 trials · 92 incl. sub-types Sub-types →
- Apraxia 17 trials · 40 incl. sub-types Sub-types →
- Auditory perceptual disorders 12 trials · 22 incl. sub-types Sub-types →
- Hallucinogen-persisting perception disorder 4 trials
- Allesthesia 1 trial
-
Neuromuscular disease 112 trials · 2,344 incl. sub-types
8 sub-types
- Peripheral neuropathy 93 trials · 1,469 incl. sub-types Sub-types →
- Hereditary neuromuscular disease 3 trials · 932 incl. sub-types Sub-types →
- Motor neuron disorder 69 trials · 506 incl. sub-types Sub-types →
- Vestibular disorder 64 trials · 92 incl. sub-types Sub-types →
- Muscular channelopathy 0 trials · 19 incl. sub-types Sub-types →
- Atrophic muscular disease 7 trials
- Neuromuscular junction disease 1 trial · 6 incl. sub-types Sub-types →
- Akinetopsia 0 trials
-
Peripheral nervous system disorder 121 trials · 2,284 incl. sub-types
18 sub-types
- Peripheral neuropathy 93 trials · 1,469 incl. sub-types Sub-types →
- Autonomic nervous system disorder 59 trials · 209 incl. sub-types Sub-types →
- Peripheral nervous system neoplasm 3 trials · 196 incl. sub-types Sub-types →
- Autoimmune disorder of peripheral nervous system 0 trials · 194 incl. sub-types Sub-types →
- Radiculopathy 160 trials
- Third cranial nerve disorder 1 trial · 86 incl. sub-types Sub-types →
- Trigeminal nerve disorder 3 trials · 63 incl. sub-types Sub-types →
- Facial nerve disorder 4 trials · 53 incl. sub-types Sub-types →
- Neuroma 20 trials · 27 incl. sub-types Sub-types →
- Olfactory nerve disorder 8 trials · 12 incl. sub-types Sub-types →
- Vestibulocochlear nerve disorder 2 trials · 11 incl. sub-types Sub-types →
- Glossopharyngeal nerve disorder 2 trials · 8 incl. sub-types Sub-types →
- Abducens nerve disorder 0 trials · 2 incl. sub-types Sub-types →
- Cauda equina syndrome 2 trials Sub-types →
- Accessory nerve disorder 1 trial Sub-types →
- Hypoglossal nerve disorder 1 trial Sub-types →
- Trochlear nerve disorder 1 trial Sub-types →
- Peroneal nerve paralysis 0 trials
-
Neurological pain disorder 1 trial · 1,830 incl. sub-types
9 sub-types
- Chronic pain syndrome 670 trials · 971 incl. sub-types Sub-types →
- Headache disorder 118 trials · 488 incl. sub-types Sub-types →
- Neuralgia 238 trials · 383 incl. sub-types Sub-types →
- Psychologic dyspareunia 31 trials
- Coccygodynia 19 trials
- Vulvodynia 18 trials
- Eagle syndrome 0 trials
- Glossodynia 0 trials
- Paroxysmal extreme pain disorder 0 trials
-
Nervous system injury 24 trials · 1,317 incl. sub-types
2 sub-types
- Brain injury 220 trials · 692 incl. sub-types Sub-types →
- Spinal cord injury 650 trials
-
Neurodevelopmental disorder 161 trials · 1,128 incl. sub-types
18 sub-types
- Complex neurodevelopmental disorder 3 trials · 871 incl. sub-types Sub-types →
- Mendelian neurodevelopmental disorder 0 trials · 207 incl. sub-types Sub-types →
- Intellectual disability 137 trials · 174 incl. sub-types Sub-types →
- Williams syndrome 18 trials
- Microcephaly 4 trials · 13 incl. sub-types Sub-types →
- Atypical Rett syndrome 0 trials · 12 incl. sub-types Sub-types →
- Alternating hemiplegia 0 trials · 3 incl. sub-types Sub-types →
- Aicardi syndrome 2 trials
- Hao-Fountain syndrome 0 trials Sub-types →
- TCF7L2-related neurodevelopmental disorder 0 trials
- Yoon-Bellen neurodevelopmental syndrome 0 trials
- Neurodevelopmental disorder with microcephaly, hypotonia, and absent language 0 trials
- Neurodevelopmental disorder with parkinsonism or other movement abnormalities 0 trials
- Neurodevelopmental disorder with poor growth, absent speech, progressive ataxia, and dysmorphic facies 0 trials
- Neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss 0 trials
- Neurodevelopmental disorder with seizures and brain abnormalities 0 trials
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome 0 trials Sub-types →
- Toluene embryopathy 0 trials
-
Autoimmune disorder of the nervous system 47 trials · 1,060 incl. sub-types
4 sub-types
- Autoimmune disorder of central nervous system 2 trials · 874 incl. sub-types Sub-types →
- Autoimmune disorder of peripheral nervous system 0 trials · 194 incl. sub-types Sub-types →
- Pediatric acute-onset neuropsychiatric syndrome 8 trials · 10 incl. sub-types Sub-types →
- Autoimmune retinopathy 0 trials
-
Retinal disorder 89 trials · 959 incl. sub-types
32 sub-types
- Retinal degeneration 41 trials · 572 incl. sub-types Sub-types →
- Retinal vascular disorder 9 trials · 324 incl. sub-types Sub-types →
- Inherited vitreoretinopathy 0 trials · 58 incl. sub-types Sub-types →
- Retinal detachment 28 trials · 52 incl. sub-types Sub-types →
- Retina neoplasm 2 trials · 36 incl. sub-types Sub-types →
- Retinal edema 1 trial · 28 incl. sub-types Sub-types →
- Macular holes 19 trials
- Night blindness 5 trials · 10 incl. sub-types Sub-types →
- Retinitis 1 trial · 10 incl. sub-types Sub-types →
- Central serous chorioretinopathy 8 trials
- Proliferative vitreoretinopathy 7 trials Sub-types →
- Achromatopsia 4 trials · 6 incl. sub-types Sub-types →
- Retinal ciliopathy 0 trials · 2 incl. sub-types Sub-types →
- Hypertensive retinopathy 1 trial
- Iris hypoplasia with glaucoma 1 trial
- Retinal ischemia 1 trial
- Retinal nerve fiber layer disorder 1 trial Sub-types →
- Eales disease 0 trials
- Acute macular neuroretinopathy 0 trials
- Angioid streaks 0 trials Sub-types →
- Autoimmune retinopathy 0 trials
- Bradyopsia 0 trials Sub-types →
- Cancer-associated retinopathy 0 trials
- Congenital retinal arteriovenous communication 0 trials
- Isolated chorioretinal dystrophy 0 trials
- Isolated foveal hypoplasia 0 trials
- Melanoma associated retinopathy 0 trials
- Myopic macular degeneration 0 trials
- Osteogenesis imperfecta-retinopathy-seizures-intellectual disability syndrome 0 trials
- Persistent placoid maculopathy 0 trials
- Rubeosis iridis 0 trials
- Torpedo maculopathy 0 trials
-
Movement disorder 108 trials · 805 incl. sub-types
54 sub-types
- Extrapyramidal and movement disease 0 trials · 149 incl. sub-types Sub-types →
- Cerebellar ataxia 40 trials · 144 incl. sub-types Sub-types →
- Multiple system atrophy 110 trials · 119 incl. sub-types Sub-types →
- Essential tremor 102 trials · 104 incl. sub-types Sub-types →
- Progressive supranuclear palsy 73 trials · 77 incl. sub-types Sub-types →
- Huntington disease 76 trials Sub-types →
- Progressive non-fluent aphasia 23 trials · 44 incl. sub-types Sub-types →
- Behavioral variant of frontotemporal dementia 21 trials · 42 incl. sub-types Sub-types →
- Tourette syndrome 41 trials
- Corticobasal syndrome 19 trials
- Frontotemporal dementia with motor neuron disease 13 trials · 19 incl. sub-types Sub-types →
- Chronic tic disorder 15 trials
- Choreatic disease 11 trials Sub-types →
- Neurodegeneration with brain iron accumulation 1 trial · 8 incl. sub-types Sub-types →
- Arthrogryposis 4 trials · 6 incl. sub-types Sub-types →
- Inherited Creutzfeldt-Jakob disease 5 trials
- Primary orthostatic tremor 5 trials
- Clonic hemifacial spasm 4 trials
- Familial congenital mirror movements 3 trials Sub-types →
- Transient tic disorder 3 trials
- Dyskinesia with orofacial involvement, autosomal dominant 2 trials
- Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome 2 trials
- Opsoclonus-myoclonus syndrome 2 trials
- Lafora disease 1 trial Sub-types →
- PRRT2-associated paroxysmal movement disorder 0 trials · 1 incl. sub-types Sub-types →
- Unverricht-Lundborg syndrome 1 trial
- Benign shuddering attacks 1 trial
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder 1 trial
- Intellectual disability-hyperkinetic movement-truncal ataxia syndrome 0 trials · 1 incl. sub-types Sub-types →
- Myoclonus, familial 1 trial Sub-types →
- Neuronal intranuclear inclusion disease 1 trial
- Psychogenic movement disorders 1 trial
- Huntington disease-like 3 0 trials
- Huntington disease-like syndrome due to C9ORF72 expansions 0 trials
- SLC6A3-related dopamine transporter deficiency syndrome 0 trials Sub-types →
- Sandifer syndrome 0 trials
- Benign paroxysmal tonic upgaze of childhood with ataxia 0 trials
- Brain-lung-thyroid syndrome 0 trials
- Childhood-onset benign chorea with striatal involvement 0 trials
- Complex movement disorder with or without neurodevelopmental features 0 trials Sub-types →
- Epilepsy with myoclonic absences 0 trials
- Hereditary geniospasm 0 trials
- Hyperekplexia 0 trials Sub-types →
- Isolated facial myokymia 0 trials
- Kuru 0 trials
- Lingual-facial-buccal dyskinesia 0 trials
- Neuroacanthocytosis 0 trials Sub-types →
- Progressive essential tremor-speech impairment-facial dysmorphism-intellectual disability-abnormal behavior syndrome 0 trials
- Progressive myoclonic epilepsy type 7 0 trials
- Proximal myopathy with extrapyramidal signs 0 trials
- Sensorineural hearing loss-early graying-essential tremor syndrome 0 trials
- Spinal muscular atrophy-progressive myoclonic epilepsy syndrome 0 trials
- Tremor-nystagmus-duodenal ulcer syndrome 0 trials
- Variably protease-sensitive prionopathy 0 trials
-
Cranial nerve neuropathy 4 trials · 390 incl. sub-types
17 sub-types
- Cranial nerve palsy 2 trials · 121 incl. sub-types Sub-types →
- Optic nerve disorder 23 trials · 95 incl. sub-types Sub-types →
- Third cranial nerve disorder 1 trial · 86 incl. sub-types Sub-types →
- Ocular motility disease 4 trials · 65 incl. sub-types Sub-types →
- Trigeminal nerve disorder 3 trials · 63 incl. sub-types Sub-types →
- Cranial neuralgia 0 trials · 53 incl. sub-types Sub-types →
- Facial nerve disorder 4 trials · 53 incl. sub-types Sub-types →
- Olfactory nerve disorder 8 trials · 12 incl. sub-types Sub-types →
- Vestibulocochlear nerve disorder 2 trials · 11 incl. sub-types Sub-types →
- Cranial nerve neoplasm 0 trials · 8 incl. sub-types Sub-types →
- Glossopharyngeal nerve disorder 2 trials · 8 incl. sub-types Sub-types →
- Abducens nerve disorder 0 trials · 2 incl. sub-types Sub-types →
- Jaw-winking syndrome 2 trials Sub-types →
- Accessory nerve disorder 1 trial Sub-types →
- Hypoglossal nerve disorder 1 trial Sub-types →
- Trochlear nerve disorder 1 trial Sub-types →
- Pseudobulbar palsy 0 trials
-
Congenital nervous system disorder 1 trial · 284 incl. sub-types
217 sub-types
- Spina bifida 44 trials · 59 incl. sub-types Sub-types →
- Combined pituitary hormone deficiencies, genetic form 1 trial · 42 incl. sub-types Sub-types →
- Prader-Willi syndrome 31 trials Sub-types →
- 22q11.2 deletion syndrome 7 trials · 13 incl. sub-types Sub-types →
- Leber congenital amaurosis 10 trials · 12 incl. sub-types Sub-types →
- Chediak-Higashi syndrome 9 trials
- Congenital laryngeal palsy 9 trials
- Congenital muscular dystrophy 1 trial · 9 incl. sub-types Sub-types →
- Congenital myotonic dystrophy 9 trials
- Congenital vitreoretinal dysplasia 0 trials · 9 incl. sub-types Sub-types →
- Progressive external ophthalmoplegia 4 trials · 8 incl. sub-types Sub-types →
- Qualitative or quantitative defects of protein involved in O-glycosylation of alpha-dystroglycan 0 trials · 8 incl. sub-types Sub-types →
- RYR1-related myopathy 5 trials · 6 incl. sub-types Sub-types →
- MERRF syndrome 5 trials
- Smith-Magenis syndrome 5 trials
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Congenital nystagmus 4 trials · 5 incl. sub-types Sub-types →
- TTN-related myopathy 2 trials · 4 incl. sub-types Sub-types →
- Corpus callosum, agenesis of 4 trials Sub-types →
- Mitochondrial neurogastrointestinal encephalomyopathy 4 trials Sub-types →
- Severe intellectual disability-progressive spastic diplegia syndrome 4 trials
- Rubinstein-Taybi syndrome 3 trials Sub-types →
- TPM2-related myopathy 1 trial · 3 incl. sub-types Sub-types →
- Cerebral cavernous malformation 3 trials Sub-types →
- Congenital hydrocephalus 1 trial · 3 incl. sub-types Sub-types →
- Congenital stationary night blindness autosomal dominant 1 3 trials
- Familial congenital mirror movements 3 trials Sub-types →
- Syndromic X-linked intellectual disability Lubs type 3 trials Sub-types →
- FOXG1 disorder 2 trials
- KBG syndrome 2 trials
- Mobius syndrome 2 trials Sub-types →
- Mowat-Wilson syndrome 2 trials Sub-types →
- PHACE syndrome 2 trials
- Childhood-onset nemaline myopathy 1 trial · 2 incl. sub-types Sub-types →
- Congenital toxoplasmosis 2 trials
- Isolated hereditary congenital facial paralysis 2 trials Sub-types →
- Meningocele 2 trials Sub-types →
- Postsynaptic congenital myasthenic syndrome 0 trials · 2 incl. sub-types Sub-types →
- AICA-ribosiduria 1 trial
- Bohring-Opitz syndrome 1 trial
- Cohen syndrome 1 trial
- Freeman-Sheldon syndrome 1 trial Sub-types →
- Schuurs-Hoeijmakers syndrome 1 trial
- TPM3-related myopathy 1 trial Sub-types →
- Anencephaly 1 trial Sub-types →
- Autism spectrum disorder due to AUTS2 deficiency 1 trial
- Autosomal recessive limb-girdle muscular dystrophy type 2R1 1 trial
- Autosomal recessive limb-girdle muscular dystrophy type 2Y 1 trial
- Cephalocele 0 trials · 1 incl. sub-types Sub-types →
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder 1 trial
- Chromosome 15q13.3 microdeletion syndrome 1 trial
- Congenital contractural arachnodactyly 1 trial
- Congenital stationary night blindness autosomal dominant 2 1 trial
- Intellectual disability-microcephaly-strabismus-behavioral abnormalities syndrome 1 trial
- Isolated cerebellar hypoplasia/agenesis 1 trial
- Macrocephaly-intellectual disability-neurodevelopmental disorder-small thorax syndrome 1 trial
- Myopathy caused by variation in POMGNT1 0 trials · 1 incl. sub-types Sub-types →
- Neuropathy, congenital hypomelinating 0 trials · 1 incl. sub-types Sub-types →
- Polymicrogyria 1 trial Sub-types →
- Sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 1 trial Sub-types →
- Severe congenital nemaline myopathy 0 trials · 1 incl. sub-types Sub-types →
- Syndromic X-linked intellectual disability 5 1 trial
- 3q27.3 microdeletion syndrome 0 trials
- 7p22.1 microduplication syndrome 0 trials
- 9q31.1q31.3 microdeletion syndrome 0 trials
- 9q33.3q34.11 microdeletion syndrome 0 trials
- ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder 0 trials
- Aase-Smith syndrome 0 trials
- Al Gazali Khidr Prem Chandran syndrome 0 trials
- B4GALT1-congenital disorder of glycosylation 0 trials
- Bailey-Bloch congenital myopathy 0 trials
- Bardet-Biedl syndrome 11 0 trials
- CTCF-related neurodevelopmental disorder 0 trials
- DYRK1A-related intellectual disability syndrome 0 trials Sub-types →
- EEM syndrome 0 trials
- Houge-Janssens syndrome 1 0 trials
- Johanson-Blizzard syndrome 0 trials
- MYH7-related skeletal myopathy 0 trials
- Myhre syndrome 0 trials
- PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome 0 trials
- Pierpont syndrome 0 trials
- Pitt-Hopkins-like syndrome 2 0 trials
- Prader-Willi-like syndrome 0 trials Sub-types →
- Ritscher-Schinzel syndrome 0 trials Sub-types →
- SIN3A-related intellectual disability syndrome 0 trials Sub-types →
- SLC39A8-CDG 0 trials
- Schinzel-Giedion syndrome 0 trials
- TELO2-related intellectual disability-neurodevelopmental disorder 0 trials
- Wieacker-Wolff syndrome 0 trials
- X-linked adrenal hypoplasia congenita 0 trials Sub-types →
- X-linked congenital stationary night blindness 0 trials Sub-types →
- X-linked intellectual disability with marfanoid habitus 0 trials
- X-linked intellectual disability, Cabezas type 0 trials
- X-linked intellectual disability, Pai type 0 trials
- X-linked intellectual disability, Stevenson type 0 trials
- X-linked intellectual disability, Stoll type 0 trials
- X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome 0 trials
- X-linked intellectual disability-cubitus valgus-dysmorphism syndrome 0 trials
- X-linked intellectual disability-epilepsy-progressive joint contractures-dysmorphism syndrome 0 trials
- X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome 0 trials
- X-linked intellectual disability-hypogonadism-ichthyosis-obesity-short stature syndrome 0 trials
- X-linked intellectual disability-plagiocephaly syndrome 0 trials
- X-linked intellectual disability-short stature-overweight syndrome 0 trials
- X-linked recessive mitochondrial myopathy 0 trials
- Adult-onset nemaline myopathy 0 trials
- Alpha-actinopathy 0 trials Sub-types →
- Autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome 0 trials
- Autosomal dominant primary microcephaly 0 trials Sub-types →
- Autosomal recessive spinocerebellar ataxia 20 0 trials
- Blepharophimosis - intellectual disability syndrome, MKB type 0 trials
- Cardiac anomalies - developmental delay - facial dysmorphism syndrome 0 trials
- Cerebellar-facial-dental syndrome 0 trials
- Cone-rod synaptic disorder, congenital nonprogressive 0 trials
- Congenital abducens nerve palsy 0 trials
- Congenital achiasma 0 trials
- Congenital axonal neuropathy with encephalopathy 0 trials
- Congenital cataracts-facial dysmorphism-neuropathy syndrome 0 trials
- Congenital epulis 0 trials
- Congenital fibrosis of extraocular muscles type 1 0 trials
- Congenital insensitivity to pain with hyperhidrosis 0 trials
- Congenital insensitivity to pain with severe intellectual disability 0 trials
- Congenital insensitivity to pain-hypohidrosis syndrome 0 trials
- Congenital labioscrotal agenesis-cerebellar malformation-corneal dystrophy-facial dysmorphism syndrome 0 trials
- Congenital lactic acidosis, Saguenay-Lac-Saint-Jean type 0 trials
- Congenital myasthenic syndrome 15 0 trials
- Congenital myasthenic syndrome 18 0 trials
- Congenital myasthenic syndrome 6 0 trials
- Congenital myasthenic syndrome with tubular aggregates 0 trials Sub-types →
- Congenital myopathy 7A, myosin storage, autosomal dominant 0 trials
- Congenital neuronal ceroid lipofuscinosis 10 0 trials
- Congenital oculomotor nerve palsy 0 trials
- Congenital or early infantile CACH syndrome 0 trials
- Congenital retinal arteriovenous communication 0 trials
- Congenital stationary night blindness 1B 0 trials
- Congenital stationary night blindness 1D 0 trials
- Congenital stationary night blindness 1G 0 trials
- Congenital stationary night blindness autosomal dominant 3 0 trials
- Congenital trigeminal anesthesia 0 trials
- Craniorachischisis 0 trials
- Developmental and epileptic encephalopathy, 15 0 trials
- Developmental and epileptic encephalopathy, 18 0 trials
- Developmental and epileptic encephalopathy, 23 0 trials
- Developmental and epileptic encephalopathy, 36 0 trials
- Developmental and epileptic encephalopathy, 50 0 trials
- Developmental and epileptic encephalopathy, 73 0 trials
- Developmental and epileptic encephalopathy, 77 0 trials
- Developmental malformations-deafness-dystonia syndrome 0 trials
- Diastematomyelia 0 trials
- Distal arthrogryposis Moore weaver type 0 trials
- Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome 0 trials
- Facial dysmorphism-macrocephaly-myopia-Dandy-Walker malformation syndrome 0 trials
- Familial congenital palsy of trochlear nerve 0 trials
- Fibrosis of extraocular muscles, congenital, 2 0 trials
- Fibrosis of extraocular muscles, congenital, 3c 0 trials
- Fibrosis of extraocular muscles, congenital, 5 0 trials
- Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome 0 trials
- Holoprosencephaly 0 trials Sub-types →
- Holoprosencephaly-hypokinesia-congenital contractures syndrome 0 trials
- Hyaline body myopathy 0 trials
- Hypomyelinating leukodystrophy 10 0 trials
- Hypotonia, infantile, with psychomotor retardation and characteristic facies 0 trials Sub-types →
- Infantile-onset X-linked spinal muscular atrophy 0 trials
- Intellectual developmental disorder with dysmorphic facies, seizures, and distal limb anomalies 0 trials
- Intellectual developmental disorder with gastrointestinal difficulties and high pain threshold 0 trials
- Intellectual disability, Buenos-Aires type 0 trials
- Intellectual disability, Wolff type 0 trials
- Intellectual disability, X-linked, syndromic 33 0 trials
- Intellectual disability, autosomal dominant 47 0 trials
- Intellectual disability, autosomal dominant 48 0 trials
- Intellectual disability, autosomal recessive 12 0 trials
- Intellectual disability, autosomal recessive 53 0 trials
- Intellectual disability-sparse hair-brachydactyly syndrome 0 trials
- Intermediate nemaline myopathy 0 trials Sub-types →
- Isolated exencephaly 0 trials
- Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome 0 trials
- Lissencephaly spectrum disorders 0 trials Sub-types →
- Macrocephaly-short stature-paraplegia syndrome 0 trials
- Macrocephaly-spastic paraplegia-dysmorphism syndrome 0 trials
- Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome 0 trials
- Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome 0 trials
- Multiple congenital anomalies-hypotonia-seizures syndrome 2 0 trials
- Multiple pterygium-malignant hyperthermia syndrome 0 trials
- Myasthenia, congenital, refractory to acetylcholinesterase inhibitors 0 trials
- Myasthenic syndrome, congenital, 22 0 trials
- Myasthenic syndrome, congenital, 23, presynaptic 0 trials
- Myasthenic syndrome, congenital, 24, presynaptic 0 trials
- Myasthenic syndrome, congenital, 25, presynaptic 0 trials
- Myasthenic syndrome, congenital, 7B, presynaptic, autosomal recessive 0 trials
- Myofibrillar myopathy 1 0 trials
- Myofibrillar myopathy 3 0 trials
- Myofibrillar myopathy 4 0 trials
- Myofibrillar myopathy 5 0 trials
- Myofibrillar myopathy 7 0 trials Sub-types →
- Myopathy, myofibrillar, 13, with rimmed vacuoles 0 trials
- Neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies 0 trials
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-hip dysplasia syndrome 0 trials Sub-types →
- Night blindness, congenital stationary, type1i 0 trials
- Periventricular nodular heterotopia 0 trials Sub-types →
- Prenatal-onset spinal muscular atrophy with congenital bone fractures 0 trials Sub-types →
- Progressive myoclonic epilepsy type 3 0 trials
- Radioulnar synostosis-developmental delay-hypotonia syndrome 0 trials
- Schizencephaly 0 trials Sub-types →
- Segmental spinal dysgenesis 0 trials
- Severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome 0 trials
- Severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome 0 trials
- Severe microbrachycephaly-intellectual disability-athetoid cerebral palsy syndrome 0 trials
- Short stature-brachydactyly-obesity-global developmental delay syndrome 0 trials
- Spastic paraplegia-severe developmental delay-epilepsy syndrome 0 trials
- Spondyloepiphyseal dysplasia, sensorineural hearing loss, impaired intellectual development, and leber congenital amaurosis 0 trials
- Subcortical band heterotopia 0 trials Sub-types →
- Syndromic X-linked intellectual disability 34 0 trials
- Syndromic X-linked intellectual disability 7 0 trials
- Syndromic X-linked intellectual disability Abidi type 0 trials
- Syndromic X-linked intellectual disability Claes-Jensen type 0 trials
- Syndromic X-linked intellectual disability Shashi type 0 trials
- Syndromic X-linked intellectual disability Siderius type 0 trials
- Typical nemaline myopathy 0 trials Sub-types →
-
Infectious disorder of the nervous system 4 trials · 231 incl. sub-types
10 sub-types
- Central nervous system infectious disorder 10 trials · 163 incl. sub-types Sub-types →
- Tetanus 43 trials Sub-types →
- Rabies 27 trials
- Tropical spastic paraparesis 3 trials
- Cytomegalovirus retinitis 2 trials
- Tabes dorsalis 2 trials
- Histoplasmosis retinitis 1 trial
- Ophthalmic herpes zoster 0 trials
- Postinfectious cerebellitis 0 trials
- Tick paralysis 0 trials
-
Neurocutaneous syndrome 2 trials · 171 incl. sub-types
9 sub-types
- Neurofibromatosis 19 trials · 94 incl. sub-types Sub-types →
- Tuberous sclerosis 41 trials · 44 incl. sub-types Sub-types →
- Von Hippel-Lindau disease 27 trials
- Sturge-Weber syndrome 8 trials
- Nevoid basal cell carcinoma syndrome 5 trials Sub-types →
- Neurocutaneous melanocytosis 1 trial
- Wyburn-Mason syndrome 0 trials
- Phakomatosis pigmentokeratotica 0 trials
- Phakomatosis pigmentovascularis 0 trials Sub-types →
-
Atactic disorder 5 trials · 148 incl. sub-types
4 sub-types
- Cerebellar ataxia 40 trials · 144 incl. sub-types Sub-types →
- Hereditary ataxia 2 trials · 119 incl. sub-types Sub-types →
- Acquired ataxia 0 trials · 1 incl. sub-types Sub-types →
- Sensory ataxia 0 trials Sub-types →
-
AL amyloidosis 92 trials · 98 incl. sub-types
2 sub-types
- Primary systemic amyloidosis 22 trials
- Primary localized amyloidosis 0 trials
-
Neuromyelitis optica 85 trials
-
Primary orthostatic hypotension 12 trials · 83 incl. sub-types
2 sub-types
- Inherited orthostatic hypotension 0 trials · 71 incl. sub-types Sub-types →
- Peripheral motor neuropathy-dysautonomia syndrome 0 trials
-
Developmental disability 81 trials
5 sub-types
-
Toxic encephalopathy 28 trials · 74 incl. sub-types
5 sub-types
- Hepatic encephalopathy 44 trials Sub-types →
- Carbon monoxide-induced delayed encephalopathy 1 trial
- Manganese poisoning 1 trial
- Minamata disease 0 trials
- Chronic bilirubin encephalopathy 0 trials
-
Specific learning disability 19 trials · 66 incl. sub-types
2 sub-types
- Specific language disorder 8 trials · 45 incl. sub-types Sub-types →
- Non-verbal learning disability 2 trials
-
Central nervous system malformation 5 trials · 51 incl. sub-types
54 sub-types
- Neural tube defect 12 trials · 23 incl. sub-types Sub-types →
- Overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes 0 trials · 10 incl. sub-types Sub-types →
- Hoyeraal-Hreidarsson syndrome 3 trials
- Pontocerebellar hypoplasia 1 trial · 3 incl. sub-types Sub-types →
- Lhermitte-Duclos disease 2 trials
- PHACE syndrome 2 trials
- Joubert syndrome with oculorenal defect 1 trial Sub-types →
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder 1 trial
- Cystic malformation of the posterior fossa 0 trials · 1 incl. sub-types Sub-types →
- Syndromic X-linked intellectual disability 5 1 trial
- Aase-Smith syndrome 0 trials
- B4GALT1-congenital disorder of glycosylation 0 trials
- Dandy-Walker malformation-postaxial polydactyly syndrome 0 trials
- Gomez-Lopez-Hernandez syndrome 0 trials
- Joubert syndrome with ocular defect 0 trials Sub-types →
- NPHP3-related Meckel-like syndrome 0 trials
- Ritscher-Schinzel syndrome 0 trials Sub-types →
- SLC39A8-CDG 0 trials
- TELO2-related intellectual disability-neurodevelopmental disorder 0 trials
- X-linked cerebral-cerebellar-coloboma syndrome syndrome 0 trials
- X-linked intellectual disability-cerebellar hypoplasia syndrome 0 trials
- X-linked intellectual disability-cerebellar hypoplasia-spondylo-epiphyseal dysplasia syndrome 0 trials
- Aprosencephaly cerebellar dysgenesis 0 trials
- Arachnoid cyst 0 trials Sub-types →
- Ataxia - intellectual disability - oculomotor apraxia - cerebellar cysts syndrome 0 trials
- Autosomal recessive spinocerebellar ataxia 20 0 trials
- Cerebellar-facial-dental syndrome 0 trials
- Cerebral gigantism-jaw cysts syndrome 0 trials
- Cervical hypertrichosis-peripheral neuropathy syndrome 0 trials
- Congenital labioscrotal agenesis-cerebellar malformation-corneal dystrophy-facial dysmorphism syndrome 0 trials
- Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome 0 trials
- Facial dysmorphism-macrocephaly-myopia-Dandy-Walker malformation syndrome 0 trials
- Glioependymal/ependymal cyst 0 trials
- Global developmental delay-visual anomalies-progressive cerebellar atrophy-truncal hypotonia syndrome 0 trials
- Hereditary cerebral malformation 0 trials
- Holoprosencephaly-caudal dysgenesis syndrome 0 trials
- Holoprosencephaly-hypokinesia-congenital contractures syndrome 0 trials
- Hypomyelinating leukodystrophy 8 with or without oligodontia and-or hypogonadotropic hypogonadism 0 trials
- Isolated arhinencephaly 0 trials
- Isolated bilateral hemispheric cerebellar hypoplasia 0 trials
- Isolated cerebellar vermis agenesis 0 trials Sub-types →
- Isolated cerebellar vermis hypoplasia 0 trials
- Isolated unilateral hemispheric cerebellar hypoplasia 0 trials
- Lethal fetal cerebrorenogenitourinary agenesis/hypoplasia syndrome 0 trials
- Macrocephaly-short stature-paraplegia syndrome 0 trials
- Orofaciodigital syndrome type 6 0 trials
- Partial corpus callosum agenesis-cerebellar vermis hypoplasia with posterior fossa cysts syndrome 0 trials
- Permanent neonatal diabetes mellitus-pancreatic and cerebellar agenesis syndrome 0 trials
- Pontine tegmental cap dysplasia 0 trials
- Rhombencephalosynapsis 0 trials
- Severe intellectual disability-corpus callosum agenesis-facial dysmorphism-cerebellar ataxia syndrome 0 trials
- Spinal muscular atrophy-Dandy-Walker malformation-cataracts syndrome 0 trials
- Syndromic X-linked intellectual disability Najm type 0 trials
- Tubulinopathy-associated dysgyria 0 trials
-
Restless legs syndrome 45 trials
-
Neuroendocrine disorder 0 trials · 42 incl. sub-types
4 sub-types
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Central diabetes insipidus 5 trials · 12 incl. sub-types Sub-types →
- Cyclic vomiting syndrome 8 trials
- Posterior pituitary gland neoplasm 0 trials Sub-types →
-
Qualitative or quantitative protein defects in neuromuscular diseases 0 trials · 30 incl. sub-types
19 sub-types
- Sarcoglycanopathy 3 trials · 10 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of alpha-dystroglycan 0 trials · 8 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of dystrophin 4 trials · 5 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of titin 0 trials · 4 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of tropomyosin 0 trials · 4 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of dysferlin 0 trials · 3 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of alpha-actin 0 trials · 2 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of nebulin 0 trials · 2 incl. sub-types Sub-types →
- Collagen 6-related myopathy 1 trial Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of myofibrillar proteins 0 trials · 1 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of plectin 0 trials · 1 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of selenoprotein N1 0 trials · 1 incl. sub-types Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of telethonin 0 trials · 1 incl. sub-types Sub-types →
- Alpha-actinopathy 0 trials Sub-types →
- Caveolinopathy 0 trials Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of TRIM32 0 trials Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of beta-myosin heavy chain (MYH7) 0 trials Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of perlecan 0 trials Sub-types →
- Neuromuscular disease caused by qualitative or quantitative defects of protein SERCA1 0 trials Sub-types →
-
Neuronitis 20 trials
-
Paraneoplastic neurologic syndrome 1 trial · 15 incl. sub-types
7 sub-types
- POEMS syndrome 8 trials
- Lambert-Eaton myasthenic syndrome 4 trials
- Opsoclonus-myoclonus syndrome 2 trials
- Paraneoplastic cerebellar degeneration 1 trial
- Cancer-associated retinopathy 0 trials
- Paraneoplastic limbic encephalitis 0 trials Sub-types →
- Paraneoplastic polyneuropathy 0 trials
-
Stiff-person syndrome 12 trials
3 sub-types
- Classic stiff person syndrome 0 trials
- Focal stiff limb syndrome 0 trials
- Progressive encephalomyelitis with rigidity and myoclonus 0 trials
-
Locked-in syndrome 11 trials
-
Persistent idiopathic facial pain 9 trials
-
Serotonin syndrome 6 trials
-
Synaptopathy 0 trials · 6 incl. sub-types
1 sub-type
- Neuromuscular junction disease 1 trial · 6 incl. sub-types Sub-types →
-
Barre-Lieou syndrome 3 trials
-
AA amyloidosis 2 trials
-
Balint syndrome 2 trials
-
Drug-induced akathisia 2 trials
-
Drug-induced dyskinesia 2 trials
-
Neurosarcoidosis 2 trials
1 sub-type
- Cerebral sarcoidosis 1 trial
-
Sensory ganglionopathy 2 trials
4 sub-types
- Paraneoplastic sensory ganglionopathy 1 trial
- Gasserian ganglion meningioma 0 trials
- Geniculate ganglionitis 0 trials
- Non-paraneoplastic sensory ganglionopathy 0 trials
-
Dopa-responsive dystonia 1 trial · 2 incl. sub-types
-
Periodic paralysis 1 trial · 2 incl. sub-types
1 sub-type
- Familial periodic paralysis 0 trials · 1 incl. sub-types Sub-types →
-
Wallerian degeneration 1 trial
-
Diplegia of upper limb 1 trial
-
Neuroleptic malignant syndrome 1 trial
-
Prepubertal anorexia nervosa 1 trial
-
Radiculitis 1 trial
-
Gerstmann syndrome 0 trials
-
KIF1A related neurological disorder 0 trials
3 sub-types
-
Sydenham chorea 0 trials
-
Worster-Drought syndrome 0 trials
-
Corneal-cerebellar syndrome 0 trials
-
Duplication of the pituitary gland 0 trials
-
Idiopathic recurrent stupor 0 trials
-
Meningitis-retention syndrome 0 trials
-
Neonatal brainstem dysfunction 0 trials
-
Perineural cyst 0 trials
-
Spontaneous periodic hypothermia 0 trials
-
Symmetrical thalamic calcifications 0 trials
-
Tubulinopathy 0 trials
4 sub-types
- TUBB3-related tubulinopathy 0 trials Sub-types →
- Uner Tan Syndrome 0 trials
- Complex cortical dysplasia with other brain malformations 5 0 trials
- Tubulinopathy-associated dysgyria 0 trials
-
Wet beriberi 0 trials
Most studied deeper sub-types
-
Hope for duchenne: new drug targets rare gene mutation in phase 3 trial
Disease control Recruiting nowThis study tests an experimental drug called AOC 1044 for boys with Duchenne muscular dystrophy (DMD) who have a specific genetic change (exon 44 skipping). About 70 boys aged 7 to 16 who can still walk will receive either the drug or a placebo. The main goal is to see if the dru…
Phase 3 • Sponsor: Avidity Biosciences, Inc. • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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New drug AZD5492 tested for autoimmune diseases in first human study
Disease control Recruiting nowThis Phase 1 trial tests the safety and tolerability of a new drug called AZD5492 in 72 adults with lupus, myositis, or rheumatoid arthritis. Participants receive one or two doses under the skin and are monitored for side effects and how the drug moves through the body. The study…
Phase 1 • Sponsor: AstraZeneca • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Can a Two-Drug combo quiet the tremors Parkinson's patients still feel?
Disease control Recruiting nowThis phase 2 trial tests an experimental drug called VIM0423 in adults with Parkinson's disease whose tremor does not respond well to standard dopaminergic therapy. Researchers want to see if VIM0423 can reduce tremor severity, improve daily function and quality of life, and be s…
Phase 2 • Sponsor: Vima Therapeutics • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Spinal fluid antibody shots tested for fresh spinal cord injuries
Disease control Recruiting nowResearchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…
Phase 1 • Sponsor: NovaGo Therapeutics AG • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Radioactive nanoparticles aimed at cancer that spreads to the Brain's lining
Disease control Recruiting nowResearchers are testing a radioactive drug called rhenium-186 obisbemeda in adults whose solid-tumor cancer has spread to the leptomeninges, the tissues lining the brain and spinal cord. The drug is a nanoliposome carrying rhenium-186, a radioactive isotope, and it is given throu…
Phase 1/2 • Sponsor: Cerenome • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Could a new drug slow lewy body dementia? phase 2 trial begins
Disease control Recruiting nowThis phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Killer virus turned against childhood brain cancer
Disease control Recruiting nowThis early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New hope for duchenne: targeted therapy now available for eligible patients
Disease control Expanded accessThis program provides access to an experimental drug, AOC 1044, for people with Duchenne muscular dystrophy (DMD) whose genetic mutation can be treated by skipping exon 44. The goal is to help control the disease and improve muscle function. Participants must be at least 2 years …
Sponsor: Avidity Biosciences, Inc. • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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New schizophrenia drug shows promise in Long-Term safety trial
Disease control Recruiting nowThis study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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New Alzheimer's drug injected into spine shows promise in early safety trial
Disease control Recruiting nowThis early-stage study tests a new drug called LY3954068 in 48 people with mild Alzheimer's symptoms. The drug is given directly into the spinal fluid, either once or twice, to see if it is safe and how it affects Alzheimer's markers. The study lasts up to 100 weeks and includes …
Phase 1 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Light and magnets: a new weapon against Alzheimer's?
Disease control Recruiting nowThis trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation …
Sponsor: REGEnLIFE SAS • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Ear zap may tame inflammation after spine surgery
Disease control Recruiting nowThis study tests whether a non-invasive device that gently stimulates a nerve in the ear can lower inflammation and pain after major spine surgery. About 50 adults having long-segment spinal fusion will be randomly assigned to receive the stimulation or standard care. Researchers…
Sponsor: Alexander T. Yahanda • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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Gene therapy trial offers hope for babies with rare, deadly metabolic disease
Disease control Recruiting nowThis study tests a one-time gene therapy called ECUR-506 in baby boys under 9 months old with a severe form of OTC deficiency, a genetic disorder that prevents the body from breaking down ammonia. The goal is to see if the treatment is safe and can reduce dangerous ammonia levels…
Phase 3 • Sponsor: iECURE, Inc. • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Implanted electrical system aims to restore movement in paralyzed limbs
Disease control Recruiting nowThis study tests a surgically implanted device that uses mild electrical pulses to stimulate muscles in the legs and trunk. The goal is to help people with paralysis from spinal cord injury, stroke, or other conditions exercise, stand, step, and improve balance. Ten participants …
Sponsor: Case Western Reserve University • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Could a simple ear clip tame brain swelling after a stroke?
Disease control Recruiting nowThis study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can reduce inflammation and brain swelling after a hemorrhagic stroke (intracerebral hemorrhage). The trial enrolls adults with a specific type of brain bleed and compares the ac…
Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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New drug trial offers hope for rare brain disease
Disease control Recruiting nowThis study tests an experimental drug, fosigotifator, in adults and children with Vanishing White Matter disease, a rare genetic brain disorder. The main goals are to check the drug's safety and how the body processes it. About 50 participants will take the drug for up to 201 wee…
Phase 1/2 • Sponsor: Calico Life Sciences LLC • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Could your own stem cells heal your brain? new trial tests it
Disease control Recruiting nowThis study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …
Sponsor: MD Stem Cells • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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Mind-Controlled tech: brain implant trial aims to restore independence for paralysis patients
Disease control Recruiting nowThis study tests a brain-computer implant (Stentrode) for people with paralysis from motor neuron disease or similar conditions. The device is placed in a blood vessel near the brain and aims to let users control computers or assistive devices with thought. The trial focuses on s…
Sponsor: Synchron, Inc. • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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Can a night-time breathing device boost brain power in older vets with lung and sleep troubles?
Disease control Recruiting nowThis study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea—a combination called Overlap Syndrome. About 668 participants will …
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 13:03 UTC
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Mind-Controlled tech trial launches for ALS patients
Disease control Recruiting nowThis early study tests a brain-computer implant placed through blood vessels to help people with ALS control external devices using their thoughts. Ten participants with ALS and arm weakness will be followed for safety and device function. The goal is to restore some independence…
Sponsor: Synchron, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:31 UTC
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New drug could extend window for treating deadly stroke
Disease control Recruiting nowThis trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…
Phase 2/3 • Sponsor: University of Melbourne • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Mind-Controlled tech trial launches for ALS patients
Disease control Recruiting nowThis study tests a brain-computer implant (BCI) that lets people with ALS or motor neuron disease control digital devices using only their thoughts. Ten participants will receive the implant, and researchers will monitor safety and how well the device works over one year. The goa…
Sponsor: Synchron, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Gene-Editing shot aims to halt rare nerve disease in phase 3 trial
Disease control Recruiting nowThis phase 3 trial tests a single dose of NTLA-2001, a gene-editing therapy, in 60 adults with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN), a rare genetic disease that damages nerves. Participants are randomly assigned to receive either the active treatmen…
Phase 3 • Sponsor: Intellia Therapeutics • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New hope for medium vessel stroke? trial tests direct Clot-Busting drug
Disease control Recruiting nowThis study is testing whether giving a clot-busting drug (tenecteplase) directly into the blocked brain artery can improve outcomes for people having a stroke caused by a medium-sized vessel blockage. About 282 participants will be randomly assigned to receive either the intra-ar…
Sponsor: The Second Hospital of Anhui Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New hope for DM1: Long-Term safety trial of PGN-EDODM1 now recruiting
Disease control Recruiting nowThis study is testing the long-term safety of an experimental drug called PGN-EDODM1 in 48 adults with myotonic dystrophy type 1 (DM1) who have already taken the drug in a previous study. Participants will receive the drug by IV infusion and be monitored for side effects. The goa…
Phase 2 • Sponsor: PepGen Inc • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Can a virtual program boost development in kids with brain injuries?
Disease control Recruiting nowThis study tests whether a virtual version of the Abecedarian Approach, an early childhood education program, can help children ages 0-5 who had a brain injury from lack of oxygen (HIE) or were born very prematurely. Researchers will enroll 225 families and measure parent satisfa…
Sponsor: University of Wisconsin, Madison • Aim: Disease control
Last updated Jun 27, 2026 12:01 UTC
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Gene therapy aims to restore sight in rare inherited blindness
Disease control Recruiting nowThis study tests a gene therapy called GS010 for people with Leber hereditary optic neuropathy (LHON), a genetic condition that causes rapid vision loss. Researchers will give the treatment as an injection into the eye at two different doses to see if it improves vision and mitoc…
Phase 2 • Sponsor: GenSight Biologics • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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New hope for early Alzheimer's? drug GSK4527226 tested for Long-Term safety
Disease control Recruiting nowThis study is an extension of an earlier trial, testing the long-term safety and effectiveness of the drug GSK4527226 in people with early Alzheimer's disease (mild cognitive impairment or mild dementia). All 220 participants will receive the drug, and researchers will monitor fo…
Phase 2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Can a common sedative shield your brain after bypass surgery?
Disease control Recruiting nowThis large trial tests whether the sedative dexmedetomidine can prevent long-term memory and thinking problems that often follow heart surgery. Researchers will give the drug to 2,400 adults aged 60 and older during and after their operation, then track their cognitive function f…
Phase 4 • Sponsor: Sunnybrook Health Sciences Centre • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Could a blood pressure cuff boost brain recovery after aneurysm surgery?
Disease control Recruiting nowThis study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigg…
Sponsor: Beijing Tiantan Hospital • Aim: Disease control
Last updated Jun 26, 2026 15:12 UTC
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VR diagnosis: the future of brain health testing?
Diagnosis Recruiting nowThis study tests whether a virtual reality (VR) platform called VIRADIA can accurately assess neurological and cognitive functions like memory, balance, and coordination. Researchers will compare VR test results with standard paper or in-person tests in 200 healthy volunteers and…
Sponsor: Gametherapy • Aim: Diagnosis
Last updated Jun 27, 2026 08:02 UTC
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Ear-Worn gadget aims to predict seizures before they start
Diagnosis Recruiting nowThis study is testing a wearable device that sits on the ears and uses sensors to detect and predict seizures in people with epilepsy. The device records brain, muscle, and eye activity, along with heart rate and skin signals. It will be compared to standard hospital EEG monitori…
Sponsor: Felicia Chu • Aim: Diagnosis
Last updated Jun 27, 2026 07:55 UTC
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Ambulance EEG could cut stroke treatment delays by an hour
Diagnosis Recruiting nowThis study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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One-Dose antibiotic could slash ventilator pneumonia deaths in brain injury patients
Prevention Recruiting nowThis study tests whether giving a single dose of a common antibiotic soon after a breathing tube is placed can prevent lung infections and improve survival in ICU patients with severe brain injuries. Researchers will enroll 3,300 adults on ventilators due to stroke, trauma, or la…
Phase 3 • Sponsor: The George Institute • Aim: Prevention
Last updated Aug 30, 2026 00:00 UTC
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Can a phone app nudge people toward exercise and slow Parkinson's?
Prevention Recruiting nowThis trial tests whether a smartphone app can help people with REM sleep behavior disorder, a condition that often precedes Parkinson's, become more physically active over two years. Participants receive personalized activity goals through the app and track their steps and exerci…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Could a phone app nudge people to exercise and slow Parkinson's before symptoms appear?
Prevention Recruiting nowThis trial tests whether a smartphone app can help 600 people with Parkinson's-related gene mutations increase their daily physical activity over two years. Participants set their own exercise goals and get feedback through the app. Researchers will measure changes in step counts…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Step toward prevention: app-based exercise may protect the brain in Parkinson's risk group
Prevention Recruiting nowThis study tests whether increasing physical activity through a motivational smartphone app can slow cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease and related disorders. Researchers will enroll 130 participants …
Sponsor: University Hospital, Bonn • Aim: Prevention
Last updated Jun 27, 2026 08:11 UTC
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Mindfulness may help caregivers move more and reduce heart risks
Symptom relief Recruiting nowThis study tests a brief mindfulness-based lifestyle program for caregivers of people with neurodegenerative disorders like Alzheimer's or Parkinson's. Many caregivers are not physically active, raising their risk for heart disease. The program combines in-person group sessions w…
Sponsor: The University of Hong Kong • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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New narcolepsy pill mimics Brain's Wake-Up signal in major trial
Symptom relief Recruiting nowThis study tests an experimental drug called cleminorexton in 222 adults with narcolepsy type 1 or 2. The drug mimics a natural brain protein that helps keep people awake. The goal is to see if it safely reduces daytime sleepiness and improves daily functioning. Participants must…
Phase 2/3 • Sponsor: Centessa Pharmaceuticals (UK) Limited • Aim: Symptom relief
Last updated Sep 13, 2026 00:00 UTC
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Could an electric suit ease muscle spasms and pain?
Symptom relief Recruiting nowThis study is testing a full-body suit that delivers mild electrical pulses to muscles. The goal is to see if it safely reduces spasticity, overactive reflexes, and pain in people with neurological conditions like multiple sclerosis or fibromyalgia. Fifteen adults will try both t…
Sponsor: Shirley Ryan AbilityLab • Aim: Symptom relief
Last updated Aug 30, 2026 00:00 UTC
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New pill aims to quiet Alzheimer's psychosis
Symptom relief Recruiting nowThis Phase 2 study tests an experimental drug, ML-007C-MA, to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 300 participants aged 55 to 90 will receive either the drug or a placebo. The main goal is to measure changes in psycho…
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Symptom relief
Last updated Aug 29, 2026 00:00 UTC
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New nasal device could help kids with down syndrome sleep soundly
Symptom relief Recruiting nowThis study tests a special nasal airway device (ssNPA) in 40 children with weak throat muscles and obstructive sleep apnea, including those with Down syndrome. The device is designed to keep the airway open during sleep without needing surgery. Researchers will measure how well i…
Sponsor: University of Michigan • Aim: Symptom relief
Last updated Aug 21, 2026 00:00 UTC
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Strumming for the brain: could ukulele lessons sharpen minds in MS?
Symptom relief Recruiting nowThis study tests whether a 12-week online ukulele learning program, called Music-4-MS, can improve cognitive function in people with multiple sclerosis (MS). Half the participants will learn to play the ukulele, while the other half will simply listen to music they enjoy. The goa…
Sponsor: University of Texas at Austin • Aim: Symptom relief
Last updated Aug 19, 2026 00:00 UTC
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Could a pill calm Post-Stroke muscle spasms? new trial investigates
Symptom relief Recruiting nowThis phase 2 trial tests whether an oral drug called BMS-986368 can reduce spasticity—muscle tightness and spasms—in adults who had a stroke 4 to 18 months ago. The drug works by boosting natural compounds in the body that calm overactive nerves. Researchers will measure changes …
Phase 2 • Sponsor: Alberto Esquenazi • Aim: Symptom relief
Last updated Jul 31, 2026 00:00 UTC
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Shoulder strength training may ease pain for wheelchair users
Symptom relief Recruiting nowThis study tests whether a 12-week home-based shoulder strength training program can reduce pain and improve function in manual wheelchair users with spinal cord injury. Forty participants will start training either 3 or 12 months after leaving rehab. Researchers will track pain,…
Sponsor: Swiss Paraplegic Research, Nottwil • Aim: Symptom relief
Last updated Jul 25, 2026 00:00 UTC
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New device aims to calm stress and sleeplessness without drugs
Symptom relief Recruiting nowThis study tests a device called Cereset Research to see if it can improve how the body handles stress, anxiety, and insomnia. About 200 adults with these symptoms will use the device while researchers measure heart rate and blood pressure changes. The goal is to find a non-drug …
Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief
Last updated Jul 22, 2026 00:00 UTC
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Robotic glove lends a hand: small trial tests daily life support for weak grip
Symptom relief Recruiting nowThis study tests whether a soft robotic glove called Carbonhand can help people with hand weakness from injury or nerve conditions perform daily activities at home. Five participants will use the glove for six weeks while researchers measure arm activity, grip strength, and well-…
Sponsor: Roessingh Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Smart board could bring arm rehab home for brain injury patients
Symptom relief Recruiting nowThis study tests whether a smart board device can help people with arm weakness from brain disorders (like stroke or brain injury) do rehab at home. Forty adults will either use the smart board or a workbook for 4 weeks. The goal is to see if the smart board improves arm function…
Sponsor: Samsung Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Could a magnetic helmet boost memory in Alzheimer's?
Symptom relief Recruiting nowThis study tests a device that combines magnetic brain stimulation with cognitive exercises to see if it can improve thinking and memory in people with mild Alzheimer's disease. About 180 participants aged 60-85 will receive either real or sham stimulation along with real cogniti…
Sponsor: Advanced Technology & Communications • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Your phone could help beat depression: new app trial launches
Symptom relief Recruiting nowThis study tests whether a smartphone app that tracks daily mood and symptoms can help doctors treat depression more effectively. 200 adults with depression will use the app for 6 weeks, while a comparison group receives standard care. The goal is to see if the app improves treat…
Sponsor: Centre Hospitalier Charles Perrens, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Could a magnetic helmet ease nerve pain in spinal injury patients?
Symptom relief Recruiting nowThis study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain in people with spinal cord injury. Sixty adults will receive either real or sham rTMS daily for 15 sessions while continuing their usual pain medications. Pain levels will be mea…
Sponsor: Afyonkarahisar Health Sciences University • Aim: Symptom relief
Last updated Jun 27, 2026 11:00 UTC
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Can photos help parents and ICU doctors connect? new study tests a simple idea
Symptom relief Recruiting nowThis pilot study tests a communication tool for parents of children with severe neurological problems in the intensive care unit. Parents pick 1-3 photos that show what matters to their family and share them with doctors. The goal is to see if this approach is practical, acceptab…
Phase 2 • Sponsor: Seattle Children's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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New app aims to put rehab strategies in Patients' hands
Symptom relief Recruiting nowThis study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…
Sponsor: McMaster University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Robots help recover brain power in Parkinson's, MS, and stroke patients
Symptom relief Recruiting nowThis study tests whether sensor-based robotic arm rehabilitation can improve both thinking skills (like memory and attention) and physical movement in adults with Parkinson's disease, multiple sclerosis, or stroke. Participants will receive 25 sessions of either robotic therapy w…
Sponsor: IRCCS Centro Neurolesi Bonino Pulejo • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Can a home therapy program stop repeat falls in dementia patients?
Symptom relief Recruiting nowThis study tests a program called COTID, where an occupational therapist visits the homes of older adults with dementia who have recently been hospitalized for a fall. The therapist helps make the home safer and trains the caregiver to support the patient. The goal is to see if t…
Sponsor: University Hospital, Limoges • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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New combo therapy aims to restore hand function after stroke
Symptom relief Recruiting nowThis study tests whether combining virtual reality training with a gentle brain stimulation technique can improve arm and hand movement in people who had a stroke at least three months ago. Researchers will enroll 100 adults to compare the effects of this combination on motor ski…
Sponsor: King Saud University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Brain tumor patients may sharpen thinking with At-Home rehab program
Symptom relief Recruiting nowThis study tests a remote cognitive rehabilitation program for adults with slow-growing brain tumors (grade 2 or 3 glioma) who often struggle with memory, attention, and thinking. About 187 participants will either receive the program or standard care. The goal is to see if the p…
Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Music therapy tested as a tool to boost consciousness in brain injury patients
Symptom relief Recruiting nowThis study is testing whether listening to favorite music for 30 minutes a day can improve consciousness in people with severe brain injuries, such as traumatic brain injury or disorders of consciousness. Sixty-six patients in early neurological rehabilitation will be randomly as…
Sponsor: BDH-Klinik Hessisch Oldendorf • Aim: Symptom relief
Last updated Jun 26, 2026 18:54 UTC
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Wrist device aims to zap PTSD nightmares and save hearts
Symptom relief Recruiting nowThis study tests a prescription wrist device called NightWare that detects when a veteran with PTSD is having a nightmare and gently disrupts it without waking them. Researchers want to see if better sleep from fewer nightmares can also improve blood vessel and heart health. 125 …
Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 26, 2026 16:34 UTC
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Dance class as medicine? study tests if grooving helps kids with disabilities
Symptom relief Recruiting nowThis study will test whether eight months of therapeutic dance classes (two one-hour sessions per week) can improve movement, daily activities, and quality of life in children aged 3-14 with motor impairments. Researchers will compare the dance group to children who receive no in…
Sponsor: University of Valencia • Aim: Symptom relief
Last updated Jun 26, 2026 15:42 UTC
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Spinal zaps could stop dizziness after injury
Symptom relief Recruiting nowThis study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …
Sponsor: Kessler Foundation • Aim: Symptom relief
Last updated Jun 26, 2026 13:20 UTC
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Spinal zaps could steady blood pressure in paralyzed patients
Symptom relief Recruiting nowThis study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…
Sponsor: Kessler Foundation • Aim: Symptom relief
Last updated Jun 26, 2026 12:34 UTC
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Massive device registry aims to improve patient safety
Knowledge-focused Recruiting nowThis study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…
Sponsor: Medtronic • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Can a special suit improve balance for people with brain and nerve disorders?
Knowledge-focused Recruiting nowThis study is collecting information from 200 people with cerebral palsy, multiple sclerosis, stroke, fibromyalgia, or similar nerve disorders to see how the EXOPULSE Suit affects their balance and risk of falling over time. Participants will be followed routinely, and researcher…
Sponsor: Otto Bock Healthcare Products GmbH • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
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500-Patient study aims to unravel mysteries of rare immune diseases
Knowledge-focused Recruiting nowThis study follows 500 children and adults with rare genetic disorders called type I interferonopathies, which cause severe inflammation and neurological problems. Researchers will track how the disease progresses over time and look for biological markers to improve diagnosis and…
Sponsor: Imagine Institute • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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Can a single gene therapy dose keep working for 14 years?
Knowledge-focused Recruiting nowThis study follows people who received an investigational gene therapy in an earlier iECURE trial for a urea cycle disorder, a condition that can cause dangerous ammonia buildup. Researchers will track safety, side effects, and whether the therapy's effects last over up to 14.5 y…
Sponsor: iECURE, Inc. • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Scientists map attention in damaged brains
Knowledge-focused Recruiting nowThis study looks at how people with certain types of brain damage process what they see and pay attention. Researchers will compare them to healthy volunteers using brain scans like fMRI and MEG. The goal is to better understand which brain areas are involved in visual attention.
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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NIH launches massive screening study to understand brain disorders
Knowledge-focused Recruiting nowThis study screens up to 5,000 healthy volunteers and people at risk for psychiatric or neurodevelopmental disorders like autism. Participants undergo interviews, cognitive tests, and other evaluations to see if they qualify for future research studies at NIH. The goal is to buil…
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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Massive study seeks families to unlock secrets of childhood brain disorders
Knowledge-focused Recruiting nowThis study aims to learn more about childhood-onset behavioral, psychiatric, and developmental disorders by observing people of all ages who have these conditions, along with their family members. Researchers will collect medical histories, perform psychiatric assessments, and ma…
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Aug 26, 2026 00:00 UTC
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New blood test could reveal stroke damage in real time
Knowledge-focused Recruiting nowThis study will measure a protein called BD-tau in the blood of 100 people who have had an acute ischemic stroke. Researchers will take blood samples every hour for 48 hours to see how the protein levels change over time. The goal is to better understand brain injury patterns and…
Sponsor: Ludwig-Maximilians - University of Munich • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Massive data collection launched for brain surgery patients
Knowledge-focused Recruiting nowThis study is gathering medical information and samples from up to 5,000 people with neurosurgical conditions like brain tumors, epilepsy, and Parkinson's disease. Participants receive standard care while their data is collected for future research. No new treatments are being te…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC
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Can a simple test predict Alzheimer's before symptoms worsen?
Knowledge-focused Recruiting nowThis study aims to understand brain changes in people with mild cognitive impairment (MCI) and Alzheimer's disease. Researchers will use MRI, EEG, cognitive tests, and blood and stool samples to find differences between healthy individuals and those with cognitive impairment. The…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC
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Could a Van-Mounted MRI bring brain scans to everyone?
Knowledge-focused Recruiting nowThis study compares a new portable, ultra-low field MRI to standard hospital MRI for detecting brain diseases like stroke, tumors, and epilepsy. About 200 people (ages 3 and up) with neurological symptoms, plus healthy volunteers, will get both types of scans. The goal is to see …
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Can a simple brochure get more patients into clinical trials?
Knowledge-focused Recruiting nowThis study tests a brochure called ASQ-CT that helps patients ask their doctors better questions about clinical trials. About 293 adults with cancer, heart disease, or neurological conditions will use the brochure before a doctor visit. Researchers want to see if it makes patient…
Sponsor: Barbara Ann Karmanos Cancer Institute • Aim: Knowledge-focused
Last updated Aug 08, 2026 00:03 UTC
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Scientists investigate hidden link between immune disorders and brain health
Knowledge-focused Recruiting nowThis study looks at how immune system diseases can cause problems in the brain and nerves, affecting movement, thinking, and feelings. Researchers will follow 350 people aged 2 and older with immune diseases, plus their healthy relatives, for up to 5 years. They will collect bloo…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC
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Rare disease ethics: what do patients and doctors really think about personalized trials?
Knowledge-focused Recruiting nowThis study interviews patients, families, healthcare providers, and researchers to learn their views on the ethical challenges of small-scale, personalized treatment trials for rare neurological diseases. About 385 participants will share their perspectives through semi-structure…
Sponsor: St. Jude Children's Research Hospital • Aim: Knowledge-focused
Last updated Jul 15, 2026 00:00 UTC
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ALS tissue study aims to unlock disease secrets
Knowledge-focused Recruiting nowThis study collects tissues and MRI scans from 40 adults with ALS to find markers of disease progression. Researchers will compare imaging and genetic data from spinal cord and brain areas. The goal is to better understand ALS and guide future research.
Sponsor: University of Illinois at Chicago • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
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Scientists investigate why immunotherapy attacks the nervous system
Knowledge-focused Recruiting nowThis study looks at why some cancer patients develop neurological problems after receiving immunotherapy drugs called checkpoint inhibitors. Researchers will analyze spinal fluid and blood from 160 participants to find immune cells that may mistakenly attack the nervous system. T…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
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Sleep and seizures: new study probes why stroke triggers epilepsy in some patients
Knowledge-focused Recruiting nowThis observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
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Massive global registry aims to unlock secrets of rett syndrome
Knowledge-focused Recruiting nowThis study creates a large registry of people with Rett syndrome, a rare genetic disorder that causes severe intellectual and physical disabilities. Researchers will collect information from doctors and caregivers to understand how the disease progresses over time. The goal is to…
Sponsor: International Rett Syndrome Foundation • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Brain wiring maps may forecast coma recovery after cardiac arrest
Knowledge-focused Recruiting nowThis study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Massive brain data bank opens to speed up research
Knowledge-focused Recruiting nowThis study is creating a large collection of health information and tissue samples from up to 15,000 neurosurgery patients. The goal is to provide researchers with the data they need to better understand neurological conditions and develop new treatments. Participants provide blo…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New brain scan study aims to uncover Tau's role in memory loss
Knowledge-focused Recruiting nowThis study uses a special PET scan to look at tau protein buildup in the brain and see if it relates to memory and thinking problems. Researchers will study 900 adults, some with normal memory and some with mild dementia. The goal is to better understand Alzheimer's disease, not …
Sponsor: Tammie L. S. Benzinger, MD, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Spinal circuit secrets: new study probes Stroke's hidden effects
Knowledge-focused Recruiting nowThis study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …
Sponsor: Peter C. Gerszten, MD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC
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Scientists map Brain's reaching circuits after stroke
Knowledge-focused Recruiting nowThis study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…
Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Video link in ambulance could speed up stroke care
Knowledge-focused Recruiting nowThis study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps diagnose st…
Sponsor: University of Southern Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Could fitness trackers replace fancy lab gear for walking problems?
Knowledge-focused Recruiting nowThis study tests whether commercial wearable sensors (IMUs) can accurately measure walking patterns in adults with neurological disorders like stroke or MS. Researchers will compare these sensors to standard 3D motion capture systems. If the sensors work well, they could make gai…
Sponsor: Roessingh Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Can a simple breath test diagnose diseases in children?
Knowledge-focused Recruiting nowThis study aims to see if analyzing the chemicals in a child's breath can help diagnose and monitor diseases like asthma, neurological disorders, and type 1 diabetes. Researchers will collect breath samples from up to 3,600 children and teens to find patterns linked to these cond…
Sponsor: University Children's Hospital Basel • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Brain zaps may restore speech and hand movement in stroke survivors
Knowledge-focused Recruiting nowThis study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed deep in the brain for less than 30 days to deliver mild electr…
Sponsor: Jorge Gonzalez-Martinez • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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New brain scanner could predict recovery in coma patients
Knowledge-focused Recruiting nowThis study tests a new brain scanning method called fNIRS to see if it can predict recovery in unconscious ICU patients with severe stroke or brain injury. Researchers will compare fNIRS results with standard tests in 30 patients and healthy volunteers. If successful, fNIRS could…
Sponsor: Emanuela Keller • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC
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Parkinson's puzzle: does it start in the brain or the body?
Knowledge-focused Recruiting nowThis study follows 150 people with early-stage Parkinson's disease to see if the condition starts in the brain or the body first. Researchers will track symptoms like walking problems and thinking changes over 5 years using tests, scans, and questionnaires. The goal is to better …
Sponsor: Azienda USL Reggio Emilia - IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Magnesium levels may influence brain recovery after stroke
Knowledge-focused Recruiting nowThis study looks at whether low magnesium in the blood is linked to memory, attention, and other thinking problems after a stroke. Researchers will measure magnesium levels and give cognitive tests to 80 stroke patients over several weeks. The goal is to understand if magnesium d…
Sponsor: BDH-Klinik Hessisch Oldendorf • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:10 UTC
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Major study tracks mitochondrial disease to unlock its secrets
Knowledge-focused Recruiting nowThis study follows 500 adults (400 with mitochondrial disease and 100 healthy or other-disease controls) for up to 10 years. Researchers collect medical data and samples to create a biobank, aiming to better understand how the disease progresses and to find ways to diagnose it ea…
Sponsor: Neuroscience Research Australia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:09 UTC
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Lying down vs. sitting up: does position matter for bladder tests in MS and Parkinson's?
Knowledge-focused Recruiting nowThis study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Can a simple questionnaire predict who will follow their treatment?
Knowledge-focused Recruiting nowThis study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…
Sponsor: Technical University of Madrid • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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New registry aims to unlock secrets of brain stimulation in kids
Knowledge-focused Recruiting nowThis study is creating a shared database of children who have received deep brain stimulation (DBS) for movement disorders like dystonia, epilepsy, or Tourette syndrome. By pooling data from multiple hospitals, researchers hope to answer key questions about who benefits most and …
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Massive global study aims to crack the code of rare childhood brain disorders
Knowledge-focused Recruiting nowThis study collects information from 500 children worldwide who have both epilepsy and movement disorders caused by specific gene changes. Researchers will analyze medical records to find patterns linking symptoms to genetics. The goal is to create a shared database that helps do…
Sponsor: Boston Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Scientists investigate Muscle-Brain connection in aging and brain disorders
Knowledge-focused Recruiting nowThis study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…
Sponsor: Istituti Clinici Scientifici Maugeri SpA • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Blood samples could unlock secrets of rare brain diseases
Knowledge-focused Recruiting nowThis study collects blood samples from 1000 people with rare neurological diseases that may be autoimmune. Researchers will use the samples to find new biomarkers and autoantibodies, which could help diagnose and treat these conditions in the future. Participants give extra blood…
Sponsor: University Hospital, Toulouse • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Massive biobank launches to unlock secrets of major diseases
Knowledge-focused Recruiting nowThis study collects blood, tissue, and other samples from up to 10,000 people to create a biobank for research. The goal is to help scientists study the causes of diseases like cancer, heart disease, and diabetes. Participants provide samples and basic health data, but no treatme…
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Massive study aims to unlock secrets of brain inflammation diseases
Knowledge-focused Recruiting nowThis research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…
Sponsor: Brain Inflammation Collaborative • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC
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50,000 patients join mega biobank to mine hidden clues in CT and MRI scans
Knowledge-focused Recruiting nowThis study is creating a huge collection of medical images and health information from 50,000 adults. Researchers will use advanced CT and MRI scans to find hidden patterns that could help predict, diagnose, and treat diseases like cancer, heart disease, and brain disorders. Part…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Tick-Borne mystery: alsace study digs into rare anaplasmosis cases
Knowledge-focused Recruiting nowThis study collects information from about 100 adults in Alsace who have had a confirmed case of human anaplasmosis, a bacterial infection spread by ticks. Researchers want to learn more about how common it is, what symptoms people have, and how serious it can be. The goal is to …
Sponsor: University Hospital, Strasbourg, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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New study reveals breathing risks after tonsil surgery in kids with sleep apnea
Knowledge-focused Recruiting nowThis study reviews medical records of 200 children with obstructive sleep apnea who had tonsil surgery. Researchers want to find out how often breathing problems happen after surgery, especially in children with obesity, Down syndrome, or other health issues. The goal is to bette…
Sponsor: University Hospital, Antwerp • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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New scale aims to prevent pressure sores in wheelchair users
Knowledge-focused Recruiting nowThis study is testing a new questionnaire called the Pressure Relief Frequency Scale (PReFS) to see if it can reliably help wheelchair users with neurologic disorders (like spinal cord injury, stroke, or traumatic brain injury) decide how often they need to relieve pressure to pr…
Sponsor: Baylor University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Major study launches to unravel rare genetic diseases affecting immunity and the brain
Knowledge-focused Recruiting nowThis study aims to learn more about rare genetic diseases that affect both the immune system and the nervous system. Researchers will collect medical information and samples from 1,000 participants, including patients, their relatives, and healthy volunteers. The goal is to bette…
Sponsor: Imagine Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Scientists build a 'Cognitive Atlas' for mental and neurological illnesses
Knowledge-focused Recruiting nowThis study is looking at how people with conditions like schizophrenia, bipolar disorder, depression, and neurological diseases (such as Alzheimer's or stroke) perform on computer-based thinking tests. The goal is to create a detailed map of cognitive strengths and weaknesses acr…
Sponsor: Centre Hospitalier St Anne • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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300 ART kids under the microscope: what scientists hope to learn
Knowledge-focused Recruiting nowThis study follows 300 children under age 3 who were conceived through IVF or ICSI. Researchers will measure their growth, brain development, and reproductive health to see if these conception methods have any effects. No new treatments are being tested—the goal is simply to gath…
Sponsor: Kazakhstan's Medical University "KSPH" • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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VR headset tracks eyes to unlock new diagnostic insights
Knowledge-focused Recruiting nowThis study gathers standard eye movement and pupil data from 200 healthy volunteers, children, and people with eye or brain conditions using a VR headset called neos™. The headset shows images and tracks where participants look, how their pupils react, and how their eyes move. Th…
Sponsor: machineMD AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Thick liquids might help people with swallowing problems take pills safely
Knowledge-focused Recruiting nowThis study looks at whether using a swallow gel or a semi-solid vehicle can help people with neurological conditions swallow pills more easily and safely. Researchers will observe 500 participants, including patients with swallowing disorders and healthy volunteers, as they swall…
Sponsor: Heinrich-Heine University, Duesseldorf • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Scientists hunt for Parkinson's clues with brain scans
Knowledge-focused Recruiting nowThis study uses advanced brain scans (PET, SPECT, and MRI) to find markers of Parkinson's disease in people with certain genetic mutations. Researchers will look at changes in brain chemicals and structure. The goal is to better understand the disease and help develop new treatme…
Sponsor: University of Exeter • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Blood tests may unlock secrets of rare brain disorders
Knowledge-focused Recruiting nowThis study collects blood samples from 100 people with rare brain diseases like adrenoleukodystrophy and metachromatic leukodystrophy. Researchers will study immune cells called macrophages to see if they affect how the disease progresses. No treatment is given; the goal is to le…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Can we predict who wakes up? new study seeks answers
Knowledge-focused Recruiting nowThis study follows 130 patients with disorders of consciousness after stroke, traumatic brain injury, or oxygen deprivation. Researchers will use brain scans, electrical tests, and regular check-ups to find factors that might predict if and when patients regain consciousness. The…
Sponsor: BDH-Klinik Hessisch Oldendorf • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:11 UTC
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Brain bleed survivors: is memory loss tied to shrinking hippocampus?
Knowledge-focused Recruiting nowThis study examines whether memory problems after a type of brain bleed (aneurysmal subarachnoid hemorrhage) are linked to a smaller hippocampus, a brain area key for memory. Researchers will compare 30 patients in rehabilitation with healthy volunteers using memory tests and MRI…
Sponsor: BDH-Klinik Hessisch Oldendorf • Aim: Knowledge-focused
Last updated Jun 26, 2026 18:55 UTC
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Can a High-Fat diet help kids with Tough-to-Treat conditions?
Knowledge-focused Recruiting nowThis study follows 100 children under 18 who are already on a ketogenic diet for conditions like drug-resistant epilepsy, autism, chronic migraine, or brain tumors. Researchers want to see if the diet supports healthy growth, improves symptoms, and boosts quality of life. The die…
Sponsor: Danone Nutricia SpA Società Benefit • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:44 UTC