Brain tumor patients may sharpen thinking with At-Home rehab program
NCT ID NCT06468176
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a remote cognitive rehabilitation program for adults with slow-growing brain tumors (grade 2 or 3 glioma) who often struggle with memory, attention, and thinking. About 187 participants will either receive the program or standard care. The goal is to see if the program improves how patients perceive their own thinking abilities and quality of life.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 187 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2024
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥18 years old, no age limit; * Histo-molecular diagnosis of grade 2 or 3 diffuse glioma according to World Health Organization (WHO) Classification 2016, regardless of oncological treatments previously received; * Patient in satisfactory general condition for the study, defined by a WHO performance index ≤ 2 (ECOG-Performance Status (PS) ≤ 2); * Neurosurgical excision (excluding biopsy) performed ≥ 12 months previously; * In the case of oncological treatment, patient who has completed his sessions (radiotherapy, chemotherapy) for ≥ 6 months; * Patient presenting a cognitive complaint defined as a response rated at least "Fairly" to at least one of the 2 items (n°20 and 25) assessing cognitive complaint in the EORTC QLQ-C30 questionnaire (i.e., defined as a score on the "Cognitive Functioning" scale ≤ 66.67); * Fluent in French; * Affiliation to the French Social Security System; * Possible regular use of a digital tool with Internet access; * Signature of informed consent prior to any study procedure. Exclusion Criteria: * Visual or auditory deficit not corrected to normal and/or preventing use of computer tools (i.e., homonymous lateral hemianopia is not a criterion for non-inclusion) ; * Concurrent participation in a study with cognition as primary endpoint (e.g., "POLCA", " POLO " clinical trials) ; * Legal incapacity or physical, psychological, social or geographical conditions preventing the patient from signing the consent form or completing the study ; * Unstable or uncontrolled psychiatric syndrome (i.e., psychotropic treatments are not a criterion for non-inclusion if doses are stable) ; * Known severe cognitive impairment (e.g., neurodegenerative disease, sequelae of head trauma, etc.) or defined by a score ≤ 20 on the MoCA test or impacting the ability to use digital tools at home ; * Oncological treatment (radiotherapy and/or chemotherapy and/or surgery) planned within 4 months of inclusion. Targeted anti-Isocitrate DeHydrogenase (IDH) therapies are authorized.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
8 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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CHU Amiens
NOT_YET_RECRUITINGAmiens, France
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CHU Bordeaux
NOT_YET_RECRUITINGBordeaux, France
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CHU Lyon
NOT_YET_RECRUITINGLyon, France
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CHU Nancy
NOT_YET_RECRUITINGNancy, France
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CHU Nîmes
NOT_YET_RECRUITINGNîmes, France
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Hôpital de la Timone
NOT_YET_RECRUITINGMarseille, France
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Institut Claudius Régaud
NOT_YET_RECRUITINGToulouse, 31059, France
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Institut régional du Cancer de Montpellier
RECRUITINGMontpellier, Hérault, 34298, France
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Other studies related to the condition(s) this trial covers.
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