Mood disorder

This study tests an updated version of the BRITE app, called ViraBrite, which sends suicide safety planning materials and coping skills to teens when they are feeling high emotional distress. Twenty teens who have recently attempted suicide or had suicidal thoughts with a plan wi…

This study tests a new behavioral therapy called OPT-A for teenagers who have both substance use problems and mood or anxiety disorders. 140 teens aged 10-17 will receive either OPT-A or standard treatment. Researchers will track substance use and mental health for 18 months to s…

This study tested whether training community health workers in Vietnam to deliver depression care (screening, therapy, and medication management) improves provider skills and patient outcomes. Over 1,300 patients and providers from three provinces took part. The goal was to see i…

This study tested whether personalized, intensive nursing follow-up (by phone, home visits, or hospital consultations) after a suicide attempt could prevent another attempt or crisis in people with mood disorders. 380 participants were followed for one year. The goal was to see i…

This study tested a school-based program called Preventure in 3,900 Canadian teens. The program targets four personality traits linked to substance misuse, aiming to delay or prevent alcohol and drug use. Researchers also measured whether delaying substance use helps protect cogn…

This study tested whether a home-based brain stimulation device (tDCS) could help prevent suicidal thoughts in adults recently discharged from the hospital for mood disorders. Thirty-three participants used the headset for 30 minutes a day over two weeks, supervised remotely. The…

This study tested whether taking daily vitamin D or fish oil supplements could prevent depression in over 18,000 adults without significant mood issues at the start. Participants were followed for about 5 years. The results showed that neither supplement reduced the risk of devel…

Researchers are testing whether a 10-week mindful yoga program eases depression, anxiety, and stress in women who have recently given birth. The trial enrolls 198 postpartum women with depressive symptoms and assigns them to either weekly mindful yoga sessions or a psychoeducatio…

This study tests whether using brain scans to guide transcranial magnetic stimulation (TMS) works better than standard head measurements for treating depression. Participants with major depressive disorder receive accelerated TMS, but they won't know if their treatment spot was c…

This trial tests whether a 20-minute foot massage, given daily for three days after open heart surgery, can reduce pain, improve sleep quality, and boost mood. Adults undergoing coronary artery bypass grafting who report significant pain after surgery are randomly assigned to rec…

This pilot study explores whether real-time fMRI neurofeedback can help veterans reduce suicide-specific rumination—the repetitive mental fixation on suicidal thoughts. Sixteen veterans will receive two brain-training sessions, learning to modulate activity in brain regions linke…

This trial tests whether a group-based psychological treatment for insomnia, adapted for people with depression, anxiety, or PTSD, can improve sleep and reduce psychiatric symptoms. Participants receive either the adjusted CBT-i program or usual care. The study measures changes i…

This study tested a daily dietary supplement (DITTO Cycle Supplement) in 40 women aged 18-45 who regularly experience period symptoms like cramps, bloating, fatigue, and mood swings. Over three menstrual cycles, researchers tracked changes in symptom severity and quality of life …

This six-week study tests whether two liquid supplements, BrainJuice Peach Mango and BrainJuice ACTIVE Pomegranate Acai, can improve cognitive function, performance, and mood in healthy adults aged 18-57 who have concerns in these areas. Participants drink one supplement daily fo…

This trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood shortly after a single dose. Around 53 generally healthy adults will take either one of the supplements or a placebo, then complete a series of computer and paper…

This 12-week trial tests whether two natural soy compounds, genistein and equol, can improve memory, thinking speed, and mood in healthy adults. Participants take one of the supplements or a placebo daily and complete four one-hour sessions of cognitive and mood tests. The goal i…

This study tests a therapy called the Unified Protocol, designed to help people with emotional disorders like anxiety and depression by improving emotional regulation. Researchers compare delivering the therapy in online group sessions versus in-person group sessions to see if bo…

This trial investigates whether a supplement made from Nepalese pepper (Zanthoxylum armatum) can improve cognitive abilities like attention, memory, and decision-making in young competitive gamers aged 16 to 34. Participants take either a low or high dose of the extract, caffeine…

This study investigates whether taking lion's mane mushroom or a blend of lion's mane and reishi mushroom for 28 days can improve wellbeing in women aged 18-26 who feel stressed or anxious. Participants are randomly assigned to receive one of the mushroom supplements or a placebo…

This early-phase trial tests a new brain stimulation target for people with depression plus at least one other psychiatric disorder, such as anxiety, OCD, or PTSD. The treatment uses a non-invasive form of brain stimulation called accelerated intermittent theta burst stimulation …

This early study tests a new, personalized brain stimulation method (tACS) for depression during pregnancy. Ten women (5 with depression and 5 healthy) will receive the treatment to see if it is safe, tolerable, and practical. The goal is to gather initial data to guide larger fu…

This completed study tested whether taking a daily whey protein drink rich in phospholipids for 6 to 12 weeks could improve memory, mood, and overall wellbeing in healthy adults aged 25 to 49. 119 participants were randomly assigned to receive either the active supplement or a pl…

This study tested an online group program called Healthy Minds for people on sick leave due to depression, anxiety, or adjustment disorders. 123 participants either joined the 8-week program or received standard care. Researchers tracked their return to work, symptoms, and job fu…

This study tested whether a 4-month gym exercise program helps young adults (18-35) taking antipsychotic medication for psychosis or mood disorders feel better in their daily lives. 226 participants were randomly assigned to either continue their usual care or add gym workouts. R…

This study tested a new drug, centanafadine, in 337 adults with major depression who hadn't responded well to at least one prior treatment. Some participants took the drug alone, others added it to their current antidepressant. The main goal was to see if it reduced depression sy…

This small study tested whether combining digital cognitive behavioral therapy for insomnia (CBT-I) with sessions in a sauna blanket is feasible for adults with insomnia. Ten participants used an online CBT-I program and a sauna blanket at home for 9 weeks. The goal was to see if…

This study tested whether pramipexole, a drug used for Parkinson's disease, can help people with depression who still have trouble feeling pleasure or motivation despite taking standard antidepressants. 85 adults with depression and significant anhedonia took either pramipexole o…

This study tested whether low-intensity focused ultrasound, aimed at the amygdala (a brain area linked to emotions), could reduce symptoms of depression, anxiety, bipolar disorder, and PTSD. Twenty-nine adults received daily 10-minute sessions for three weeks. Researchers measure…

This study tested a digital mental health program for adults with depressive symptoms. The program includes nine online modules covering topics like positive thinking, relaxation, and healthy habits. Researchers compared results between people with diagnosed mood disorders and th…

This study tested a behavioral therapy called BE-SMART-DR in 65 teens and young adults with bipolar disorder or major depression who had suicidal thoughts or past attempts. The therapy teaches self-directed strategies to regularize sleep and other daily rhythms to reduce short-te…

This study tested whether taking part in art activities like theatre, dance, visual arts, music, or cinema can improve mental health. 541 adults with psychiatric diagnoses were randomly assigned to either an art program or a waitlist. Researchers measured changes in depression an…

This study tested two natural supplement combinations—omega-3 plus inositol versus N-acetylcysteine (NAC)—to see if they could help children and teens (ages 5-17) with emotional ups and downs. Over 6 weeks, 27 participants took one of the two treatments. The goal was to find a ge…

This study looked at whether a new pre-workout supplement can improve endurance, strength, mood, and energy in healthy adults. Twenty-seven participants took either the supplement or a placebo before exercise tests. Researchers measured cycling endurance, bench press performance,…

This study looked at whether taking a dietary supplement for 60 days could improve thinking skills and mood in 75 university students. Participants were split into three groups: two received different supplements, and one got a placebo. Researchers measured changes in self-confid…

This study tested a liposomal magnesium supplement in 60 adults who reported low energy and mood issues. Participants took the supplement daily for 14 days and filled out questionnaires about their energy, mood, and stress levels. The trial was small, short, and had no placebo gr…

This study looked at whether kinesiological taping (a special tape applied to the skin) or foot massage can help women who had a C-section feel less pain, tiredness, and mood problems. 97 new mothers were split into three groups: one got taping, one got foot massage, and one got …

This study tested a program called Mood Lifters for college students. 125 undergraduates attended 14 weekly virtual meetings to learn mental health strategies. The goal was to see if this low-cost, peer-led approach could reduce symptoms of depression, anxiety, and stress. Resear…

This study tested whether a slow-release caffeine pill (zümXR) could improve mood, alertness, and reduce side effects like jitters compared to regular caffeine after a night of poor sleep. Thirty-six healthy adults who usually drink moderate amounts of caffeine took part. They sl…

This small pilot study tested whether combining active video games (exergaming on Nintendo Switch) with resistance training could improve frailty in 30 nursing home residents. Participants played sports games like badminton, tennis, and soccer while also doing strength exercises.…

This study tested a new 8-session psychotherapy called ChronoS in 67 adults with mood disorders (bipolar or depression) and chronic insomnia. The therapy focuses on sleep-wake awareness and habits. Researchers measured changes in insomnia severity using a standard questionnaire. …

This study tested whether a dietary supplement called Virtiva Plus, which contains ginkgo biloba, can help reduce stress and improve thinking in people aged 50 to 70 who feel stressed. Sixty participants took either a low or high dose twice daily for five weeks. Researchers measu…

This completed study compared the Tony Robbins Rapid Planning Method (RPM) seminar to regular journaling in 140 adults. Participants in the RPM group attended a three-day virtual seminar with mind-body exercises and motivational content, while the control group kept weekly to-do …

This study tested whether drinking a whey protein shake containing dairy phospholipids every day for 6 to 12 weeks could help healthy adults cope with stress. 150 people aged 25-49 took either the active drink or a placebo, then completed stressful tasks in the lab. Researchers m…

This study tested whether a drug called esketamine works as well as electroconvulsive therapy (ECT) for quickly reducing suicidal thoughts in people with depression. 340 adults with major depression or bipolar disorder and active suicidal ideas took part. They received either esk…

This study looked at how hormone changes during perimenopause (the time around menopause) might affect mood and behavior. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. No treatments were given; instead, researchers used surveys an…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study used brain scans to look at two things in people with depression or bipolar disorder: a glutamate receptor called mGluR5 and the density of connections between brain cells (synapses). Researchers compared 120 participants, including healthy volunteers, using PET and MR…

This study tested whether an AI-powered smartwatch could help teenagers and young adults with mental health conditions stick to their medication schedule. Researchers compared medication adherence in 78 people who wore the watch to those who did not. The goal was to see if the wa…

This completed study from the National Institute of Mental Health looked at over 1,500 women to better understand the symptoms of premenstrual syndrome (PMS) and a severe form called PMDD. Researchers used interviews, rating scales, and hormone tests to track mood and behavior ch…

This study used MRI and PET scans to examine the glutamate system in people with major depression, PTSD, or bipolar disorder. Researchers aimed to understand how a specific glutamate receptor (mGluR5) relates to these conditions. 180 participants aged 18-70 completed cognitive te…

This study aims to adapt and validate a French version of the PAPA questionnaire, a tool designed to screen for psychological distress in fathers during the perinatal period. Researchers will test the questionnaire with 343 couples to see if it accurately captures symptoms like a…

This completed study looked at how well a collaborative care model works for common mental health issues like anxiety and depression in four French health clinics. The model involves a care manager who coordinates between family doctors and mental health specialists. Researchers …

This study used MRI brain scans and computer tasks to understand how people who attempted suicide make decisions. Researchers compared three groups: those who used violent means, those who used non-violent means, and healthy volunteers. The goal was to find brain activity pattern…

This study tested whether a smartphone app that tracks how you type (speed, backspace use, autocorrect) can help monitor mood and thinking problems in people with mood disorders like depression or bipolar disorder. 132 adults aged 25-50 took part. The goal was to see if this simp…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…

This study tested whether smartphone notifications could improve mood, physical activity, and sleep in over 1,000 medical interns. Participants received daily mood, activity, or sleep notifications through a mobile app. The study measured mood scores, step counts, sleep duration,…

This completed study from the University of Toronto looked at whether certain gut bacteria are linked to anxiety, depression, and panic disorders. 500 adults provided stool samples to test for H. pylori and other bacteria. The goal was to understand possible root causes, not to t…

This study looked at whether walking in a forest changes heart rate, blood pressure, and mood compared to walking indoors on a treadmill. Sixteen healthy adults took part, each completing three outdoor forest walks and one indoor walk. Researchers measured heart rate variability,…

This study looked at whether giving 7-11-year-old children in Shanghai a daily breakfast with fruits and vegetables could improve their thinking, mood, and attention. Over 250 kids took part, receiving a balanced breakfast every day for 12 weeks. Researchers measured changes in c…

This study looked at how children ages 8 to 17 use smartphones and tablets, including social media and games, and how that relates to their mental health, sleep, and physical activity. Over 900 children and their parents used the Aura app and completed surveys for three months. T…

This study tested a supplement called Brain Edge, made from herbs and amino acids, to see if it quickly improves thinking or mood in healthy adults. Fifty volunteers took the supplement or a placebo in random order and completed computer tests, surveys, and VR tasks. The main goa…

This completed study from the National Institute of Mental Health surveyed over 3,600 English-speaking adults online every two weeks for six months. Researchers asked about mental health symptoms, stress, and behaviors during the COVID-19 pandemic. The goal was to understand how …

This study tested a social robot that leads activities like trivia and reminders for people with Alzheimer's or other dementias living in assisted living. Researchers wanted to see what makes it easy or hard to use the robot in daily care. 26 residents, family members, and staff …

This study tested whether a brain wave measurement called mismatch negativity (MMN) can help match veterans with mental illness to the most effective cognitive training program. 100 veterans with conditions like schizophrenia, PTSD, or mood disorders participated. The goal was to…

This study tested a program called IPS-MA, which helps people with mood or anxiety disorders find and keep jobs or return to school. 326 adults who were unable to work within three months took part. The goal was to see if this support, added to their usual treatment, helped them …

This study looked at how people aged 18-30 with early psychosis process information about their surroundings, compared to those without a psychiatric diagnosis. Participants completed computer-based tasks and cognitive training. The goal was to better understand thinking patterns…

This study looked at 48 adults with mood disorders and insomnia to see if a strong relationship with their therapist helped them get better results from a new type of therapy called ChronoS. The therapy combines sleep scheduling, mindfulness, and stress management. Researchers me…

This study tested whether a virtual therapy platform called Teleo helps children stay more engaged in online psychotherapy compared to standard video calls. Researchers enrolled 41 children with anxiety or mood disorders and measured engagement through video coding and caregiver …

This completed online study looked at whether natural environments like parks, gardens, and lakesides can improve mood and cognition in people with and without Parkinson's disease. 97 participants filled out surveys about their connection to nature, depressive symptoms, sleep, an…