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Could your gut bacteria be linked to anxiety? new study investigates

NCT ID NCT07268729

Knowledge-focused Sponsor: University of Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study from the University of Toronto looked at whether certain gut bacteria are linked to anxiety, depression, and panic disorders. 500 adults provided stool samples to test for H. pylori and other bacteria. The goal was to understand possible root causes, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward new ways to understand or treat anxiety and depression by targeting gut bacteria.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not lead to any new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

500 people

The number who actually took part.

Started

Dec 2025

Finished

Feb 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population will consist of adult males and females aged 18 to 65 recruited from the general population and outpatient mental health clinics. Participants will include individuals with clinically confirmed anxiety, depression, or panic disorder, as well as healthy control subjects with no psychiatric history. The study will aim to include participants from diverse ethnic and cultural backgrounds to ensure broad representation of the population.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Adults aged 18-65 years. * Either of the following: 1. Diagnosed with anxiety, depression, or panic disorder according to DSM-5 criteria, regardless of current treatment status. 2. Healthy individuals with no history of psychiatric disorders (control group). * Able to provide informed consent and stool sample. Exclusion Criteria: * • Diagnosis of psychotic disorders or neurocognitive conditions. * Use of systemic antibiotics or antifungals within the past 60 days.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Depression depressive disorder mood disorder panic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anxiety Depression Mood disorders Panic disorder

Contacts and locations

Locations

  • MedBliss Research Network

    Mississauga, Ontario, L5B3C2, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.