University Of Southern California

This study tests a 30-minute mobile program designed to help young adults (ages 18-24) who currently vape reduce their e-cigarette use and avoid starting smoking. About 100 participants will either receive the program or be in a control group. Researchers will compare changes in …

This study compares two antibiotics for treating early syphilis: an oral pill (cefixime) versus a standard shot (penicillin). About 400 adults with early-stage syphilis, including those with well-controlled HIV, will take part. The goal is to see if the pill works as well as the …

This study tests if a cream called imiquimod can treat precancerous spots in the mouth. About 20 adults who cannot or choose not to have surgery will apply the cream and get two follow-up biopsies. The goal is to see if the cream shrinks the spots and reduces abnormal cell change…

This study tests whether a weekly injection of tirzepatide (a drug used for diabetes and weight loss) can reduce heavy drinking and improve health in 42 adults who have both alcohol use disorder and overweight or obesity. Participants will receive either tirzepatide or a placebo …

This study tests whether taking Clomid for a longer time (instead of the usual 5 days) helps women with low egg reserve produce more mature eggs during IVF. The longer protocol aims to increase egg numbers while reducing the need for expensive injections. About 120 women will be …

This early-stage study tests whether a robotic bladder transplant from a deceased donor can work for 5 people with severe bladder damage. The goal is to see if the new bladder gets good blood flow and works better than current treatments using bowel tissue. Participants must be w…

This study tests whether a digital app (MoodBrush) or parents showing kids how to brush works better for reducing dental plaque. About 112 children aged 3-6 will brush one time in the clinic, and researchers will measure plaque before and after. The goal is to find a fun, effecti…

This study is testing whether a blood test, called a liquid biopsy, can accurately detect breast cancer. Researchers will compare the blood test results with mammograms and standard tissue diagnoses in about 490 women. If successful, this could offer a less invasive way to screen…

This study tests whether an artificial intelligence (AI) system can analyze prostate MRI scans as accurately as a radiologist to detect prostate cancer. About 130 men who need a prostate biopsy will have their MRI read by both the AI and a radiologist. The goal is to see if the A…

This study tests whether a supervised golf exercise program can improve physical function, mental health, and quality of life in prostate cancer survivors who are on hormone therapy. Twenty men aged 55-85 with little or no golf experience will participate. The program includes wa…

This study tests whether giving the sleep medication zolpidem before and after lumbar spine fusion surgery helps reduce pain and improve function. About 140 adults with degenerative lumbar disease will be randomly assigned to receive zolpidem or a placebo. The goal is to see if b…

This study tests whether a curcumin supplement can reduce inflammation and improve symptoms in people with certain blood disorders, including CCUS, low-risk MDS, and MPNs. The trial will enroll 30 participants who will receive either curcumin or a placebo for 12 months. Researche…

This study tests whether blood flow restriction (BFR) therapy or pneumatic compression (a massage-like device) works better to reduce muscle soreness after exercise. Researchers will measure jump height, muscle strength, and soreness levels in 33 recreationally active adults aged…

This study tests whether a specially designed dental environment with softer lights and sounds can reduce anxiety, pain, and distress during dental cleanings for children aged 6 to 12 with dental fear. About 312 children will be randomly assigned to a regular dental setting or a …

This study tests three types of diabetic boots to see which helps people wear them as directed. Diabetic foot ulcers can lead to amputation if not treated properly. The smart boot uses a watch and phone to remind users to keep it on. Researchers hope better boot use will speed up…

This study tests if a gentle massage technique called manual lymphatic drainage (MLD) can reduce swelling, pain, and other side effects in women with early breast cancer who are getting radiation therapy after surgery. About 50 women will take part. The goal is to see if the mass…

This study is testing a mobile app called CarePair that helps family caregivers of people with dementia find support services. The goal is to see if using the app for six weeks can reduce stress, depression, and feelings of being overwhelmed. About 80 caregivers will participate,…

This study collects blood, tissue, and bone marrow samples from people with cancer or blood disorders, as well as healthy volunteers. Researchers will use these samples to study how the immune system changes during different treatments, including immunotherapy and chemotherapy. T…

This study compares two types of self-management training for people who have had gastrointestinal (GI) cancer. One group gets a personalized program (RISE-PSMT) and the other gets a standard program. The goal is to see which helps patients better follow healthy lifestyle recomme…

This study is developing and testing a culturally informed patient navigation program for American Indian and Alaska Native cancer patients in rural California. The goal is to reduce delays between diagnosis and treatment by providing personalized support and addressing barriers …

This study aims to understand how hearing aids affect social interaction and thinking skills in older adults with hearing loss. About 100 participants aged 60 and older will wear a small audio sensor for two weeks to track their conversations, and some will also have brainwave re…

This study surveys 40 adults with non-small cell lung cancer who are already receiving immunotherapy. It aims to understand their satisfaction with current IV treatment and their interest in switching to a subcutaneous injection that could be given at home. The results will help …

This study enrolls 50 adults with any type of cancer to see if watching videos and reading materials improves their understanding of cancer clinical trials. Participants complete a survey before and after the educational materials to measure changes in knowledge and beliefs. The …

This study looks at how natural changes in estrogen and progesterone throughout the menstrual cycle influence how ready women feel to exercise, how hard they perceive a workout, and how their bodies recover afterward. Researchers will measure perceived readiness, difficulty, musc…

This study evaluates a training program for community specialists to help Hispanic/Latino adults learn about colorectal cancer prevention and genetic testing. About 140 participants from Los Angeles County will take surveys before and after the program to see if their knowledge a…

This study tests whether daily mindfulness practice, combined with heart rate biofeedback, can improve attention and memory in adults aged 50-70. Participants will practice specific breathing patterns for 10 weeks. Researchers will measure changes in blood markers linked to Alzhe…

This study tests whether a computer-generated character (called PERLA) can help cancer patients learn about genetic testing as well as a human counselor does. The goal is to make genetic testing easier to access for people who often miss out, like those in rural areas or who spea…

This study tests a personalized approach to electrical brain stimulation in 25 epilepsy patients who already have brain electrodes implanted for medical monitoring. Researchers will track each patient's brain activity and symptoms to build a model that customizes stimulation ther…

This study looks at why some people with liver cancer are diagnosed late. Researchers will survey 730 patients about things like transportation, food, and housing that may make it hard to get early cancer care. They will also interview doctors and community leaders to understand …

This study looks at the genes and health records of 500 Hispanic people with colorectal cancer. The goal is to understand why the same cancer can behave differently in different people. By linking genetic information with treatment results, researchers hope to find better ways to…

This study looks at how memory and thinking problems after a stroke affect a person's ability to relearn walking. Researchers will use walking tests, brain scans, and thinking assessments in 65 older adults who had a stroke at least 6 months ago. The goal is to find better ways t…

This study aims to enroll up to 550 adults with Down syndrome, ages 25-55, into a 'trial-ready' group. Researchers will track memory, thinking, genetics, and brain changes over time to better understand Alzheimer's disease in this population. The goal is to prepare a group of vol…

This study tests whether offering a small $25 financial reward helps recruit a more diverse group of older adults into the Alzheimer's Prevention Trial Webstudy, an online registry that tracks memory concerns. Researchers will compare this to giving out reusable grocery bags at c…

This study tracks whether women at moderately increased risk for breast cancer get recommended screening MRIs within a year of genetic counseling. Researchers will also identify what makes it easier or harder for them to follow through. About 150 women aged 30 to 75 with certain …

This study aims to find genetic markers in saliva that could predict whether a person with newly diagnosed acute lymphoblastic leukemia will develop liver damage from the drug asparaginase. Researchers will collect saliva samples from 500 participants and track liver health durin…

This study looks at whether middle-school students who have gotten in trouble at school can benefit from being trained as peer coaches. Instead of focusing on punishment, the program aims to empower these youth by giving them a positive role. Researchers will track changes in beh…

This study is testing whether a personalized AI-powered robot can help college students with generalized anxiety disorder complete their therapy homework between sessions. About 140 students will interact with the robot, which encourages them to practice cognitive behavioral ther…

This study looks at different types of depression by tracking how people manage their emotions in daily life. Researchers will measure heart rate changes and use a simple biofeedback app to see if it helps improve emotional control. The goal is to find which depression subtypes r…

This pilot study looks at two ways to treat a certain type of pelvic fracture in adults aged 60 and older. One group gets early surgery to fix the bone, while the other group gets non-surgical care with early physical therapy. The main goal is to see if a larger study is possible…

This study aims to understand why exercise helps some people with shoulder pain (rotator cuff tendinopathy) but not others. Researchers will use brain scans to see how exercise changes the brain and identify who is most likely to benefit. The study involves 60 adults aged 18-45 w…