University Of Southern California

This pilot study will test a clinic that treats both heart failure and methamphetamine use disorder at the same time. Fifty adults with heart failure and active meth use will receive counseling, incentives for staying clean, and optional addiction medications, plus standard heart…

This small pilot study will test a pharmacist-led program to control high blood pressure and cholesterol in 10 people aged 50-75 who carry the APOE ε4 gene, a major risk factor for Alzheimer's. Participants will take specific medications for six months to see if managing these he…

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

This study tests whether a brief digital program can help teenagers ages 12-17 who vape reduce their e-cigarette use and lower their risk of starting to smoke cigarettes. About 150 teens in California will take online surveys over 12 weeks, and some will also do a virtual intervi…

This study tests whether taking metformin-XR (a diabetes drug) daily before pregnancy can lower the risk and severity of Hyperemesis Gravidarum (HG)—extreme nausea and vomiting in pregnancy—in women aged 18-49 who had HG before and are trying to conceive. Participants either take…

This study tests whether offering free rideshares, hotel stays, and meal delivery helps low-income liver cancer patients start treatment sooner. About 75 uninsured or underinsured adults with liver cancer will be randomly assigned to receive these social supports plus usual patie…

This study tests K-Savvy, a 6-week online program in Korean, designed to help Korean American dementia caregivers reduce stress and depression. Researchers will enroll 120 caregivers who provide at least 10 hours of weekly care. The program adapts an existing support tool to bett…

This phase 2 trial will test whether extended-release ketamine tablets can reduce pain in 65 adults with complex regional pain syndrome (CRPS), a chronic condition causing severe, often burning pain. Participants will take either 80 mg or 160 mg of ketamine daily for several week…

This study compares voice therapy delivered in-person versus via telehealth for adults aged 55 and older with age-related voice problems. Thirty participants will receive four sessions of PhoRTE® voice exercises either face-to-face or through video calls. Researchers will measure…

This early study tests whether a wearable ultrasound device can safely stimulate retinal cells and help restore vision in people with age-related macular degeneration or retinitis pigmentosa. Five participants will receive short ultrasound pulses while reporting what they see. Th…

This study will follow 40 older adults (age 60+) with severe hearing loss who have or will receive a cochlear implant. Researchers want to see if the implant improves social interaction and thinking skills. Participants will fill out questionnaires, wear a small audio recorder fo…

This study looks at whether giving Asian college students personalized information about their alcohol metabolism and genetic risks can influence their drinking habits. Researchers will follow 450 USC students of Chinese, Japanese, Korean, or Vietnamese heritage for two years. Pa…

This study looks at how a modest daily calorie deficit of about 250 calories affects reproductive hormones like estrogen and progesterone in women using different types of birth control (oral pills, hormonal IUD, or non-hormonal IUD). Researchers will track 30 recreationally acti…

This study looks at whether a suspension walker is a practical tool for pre-walking infants with Down syndrome to use at home. Twelve infants aged 10-13 months will try using the walker for 20 minutes a day, 5 days a week over three months. Researchers want to see if families can…

This pilot study will test whether over-the-counter (OTC) hearing aids are practical and acceptable for older adults with mild-to-moderate hearing loss who are at risk for dementia. Forty participants aged 50 and older will either use the hearing aids right away or wait three mon…

This study tests whether combining a ketosis-inducing drink with treadmill exercise can increase a brain protein called BDNF and improve thinking skills. Fifty healthy adults aged 18-35 will be given either the drink or a placebo, then exercise and take cognitive tests. The resea…