University Of Southern California

This early-stage trial tests a new drug called sEphB4-HSA alongside standard chemotherapy in people with advanced or metastatic solid tumors (like head and neck, pancreatic, lung, and gallbladder cancers). The main goals are to find the best dose and check for side effects. About…

This early-phase study tests a combination of standard chemotherapy (bortezomib, dexamethasone), an immunotherapy (pembrolizumab), and a lab-modified virus (pelareorep) in people whose multiple myeloma has returned or stopped responding to prior treatments. The goal is to see if …

This study tests whether applying platelet-rich plasma (PRP) to the mesh used in hiatal hernia repair can lower the chance of the hernia returning. About 150 adults with large hiatal hernias will be randomly assigned to get either standard mesh repair or mesh plus PRP. The main g…

This early-stage trial tests a personalized cell therapy for people with advanced triple negative breast cancer that has stopped responding to standard treatments. Researchers take a patient's own immune cells, modify them in the lab to recognize a protein called NY-ESO-1 found o…

This study planned to compare four surgical techniques for treating receding gums, including flap surgery and tunneling methods, with or without a platelet-rich fibrin concentrate. It aimed to see which approach best covers exposed tooth roots and improves gum attachment. The tri…

This study looks at how well the drug enzalutamide works alone or with a radiation drug called radium-223 in men with advanced prostate cancer that has spread to bones. The goal is to see if the combination can better control the cancer by boosting the immune system and shrinking…

This study tests whether adding an experimental immune-boosting drug (anti-OX40 antibody) to the standard targeted therapy axitinib helps control advanced kidney cancer better than axitinib alone. About 62 adults whose cancer worsened after prior immunotherapy will receive either…

This study tests whether the antibiotic linezolid can effectively treat early syphilis. About 24 adults with primary, secondary, or early latent syphilis will receive linezolid, and researchers will check if their blood test levels drop enough by 6 months. The goal is to find a n…

This early-phase study tests a combination of two drugs, guadecitabine and durvalumab, in people with advanced liver, pancreatic, bile duct, or gallbladder cancer that has spread. The main goals are to find the safest dose and see if the drugs can shrink tumors. About 55 particip…

This study tests a new drug called pevonedistat alongside standard chemotherapy (cytarabine and idarubicin) in people newly diagnosed with high-risk acute myeloid leukemia (AML). The goal is to find the best dose and see if the combination improves the chance of complete remissio…

This study tests a combination of two drugs, guadecitabine and atezolizumab, in adults with myelodysplastic syndrome or chronic myelomonocytic leukemia that has spread, returned, or not responded to prior treatment. The goal is to find the best dose and see how well the drugs wor…

This early-phase study tests whether a mix of drugs and targeted radiation can help the immune system recognize and attack hard-to-treat solid tumors. About 14 adults with advanced melanoma, breast cancer, or other solid cancers that cannot be surgically removed will receive inje…

This study looks at whether measuring certain immune cells (MDSCs) in blood and urine can help detect kidney cancer early and monitor how it responds to treatment. Researchers will compare MDSC levels in healthy volunteers, patients with early-stage kidney cancer, and those with …

This study tests whether monthly group meals with guided conversation can reduce burnout and loneliness in medical students. About 80 students in their clinical years will be assigned to small groups that meet for six months. The goal is to see if this simple, social approach imp…

This study aimed to see if trazodone, a sleep medication, works better than quetiapine or a placebo for treating confusion (delirium) in adult surgical ICU patients. Researchers planned to measure how long delirium lasted, sleep quality, and side effects. However, the study was w…

This study compares two well-known psychological treatments for depression: cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT). Up to 100 adults with major depressive disorder will receive 8 weeks of online group therapy via Zoom. The goal is to see wh…

This study looks at whether using virtual reality (VR) can help reduce pain and anxiety in cancer patients who are getting a bone marrow biopsy or a lumbar puncture. About 60 participants will use VR during the procedure and report their pain and anxiety levels. The goal is to se…

This early-stage study looks at whether short-term fasting (eating less than 200 calories per day for 3 days before each treatment) is safe and doable for people with advanced or metastatic skin cancer who are receiving standard immunotherapy drugs like pembrolizumab or nivolumab…

This study compares two physical therapy approaches for children aged 8-24 months with or at high risk for cerebral palsy. One method focuses on sitting, reaching, and problem-solving, while the other targets general motor skills. The goal is to see which therapy improves sitting…

This study tests whether eating a low-calorie diet before chemotherapy can reduce side effects like fatigue, nausea, and mouth sores, and also improve how well the treatment works. About 130 adults with breast or prostate cancer will follow either a controlled low-calorie diet or…

This study planned to test a special vacuum dressing on the surgical wound after a leg amputation, comparing it to standard bandages. The goal was to see if it reduced swelling, helped people walk sooner, and was more comfortable. However, the study was withdrawn before any parti…

This study is testing a new bilingual web tool to help people with chronic sinusitis decide between surgery and other treatments. About 50 patients will use the tool or get standard information. The goal is to see if the tool helps patients make choices that match their personal …

This study aims to find genetic markers that may increase the risk of a pulmonary embolism (a serious blood clot in the lung) after total hip or knee replacement surgery. Researchers will collect blood samples from 100 adults aged 18-70 who have had a pulmonary embolism after suc…

This long-term study follows 1,500 adults with normal memory, mild cognitive impairment, or Alzheimer's disease. Researchers use brain scans, memory tests, and genetic data to understand how the disease progresses and to improve future clinical trials. The study also aims to incl…

This study aimed to see if using ChatGPT could help patients recently diagnosed with vestibular schwannoma (a non-cancerous brain tumor) feel less confused and more satisfied with their treatment choices. Researchers planned to compare decision-making scores between a group train…