New drug combo shows promise against tough leukemia
NCT ID NCT03330821
First seen Nov 16, 2025 · Last updated May 12, 2026 · Updated 27 times
Summary
This study tests a new drug called pevonedistat alongside standard chemotherapy (cytarabine and idarubicin) in people newly diagnosed with high-risk acute myeloid leukemia (AML). The goal is to find the best dose and see if the combination improves the chance of complete remission. About 53 adults will participate, and the focus is on controlling the disease rather than curing it.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Los Angeles County-USC Medical Center
Los Angeles, California, 90033, United States
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USC / Norris Comprehensive Cancer Center
Los Angeles, California, 90033, United States
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University of Arizona Cancer Center - North Campus
Tucson, Arizona, 85724, United States
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University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida, 33136, United States
Conditions
Explore the condition pages connected to this study.