Could a Fasting-Mimicking diet boost immunotherapy and vitamin c against tough colorectal cancer?

NCT ID NCT06336902

Recruiting now Disease control Sponsor: University of Southern California Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing whether combining two immunotherapy drugs (botensilimab and balstilimab) with a low-sugar, calorie-restricted diet and high-dose vitamin C is safe and tolerable for people with a specific type of advanced colorectal cancer (KRAS-mutant). The study enrolls about 15 adults whose cancer has spread and who have already tried standard treatments. The main goals are to see if patients can stick to the diet and to track side effects.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC COLORECTAL ADENOCARCINOMA STAGE IV COLORECTAL CANCER AJCC V8

Contacts and locations

Locations

Los Angeles General Medical Center
RECRUITING

Los Angeles, California, 90033, United States
Saint Jude Medical Center / Providence Medical Foundation
RECRUITING

Fullerton, California, 92835, United States
USC / Norris Comprehensive Cancer Center
RECRUITING

Los Angeles, California, 90033, United States

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