Could a Fasting-Mimicking diet boost immunotherapy and vitamin c against tough colorectal cancer?

NCT ID NCT06336902

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial is testing whether combining two immunotherapy drugs (botensilimab and balstilimab) with a low-sugar, calorie-restricted diet and high-dose vitamin C is safe and tolerable for people with a specific type of advanced colorectal cancer (KRAS-mutant). The study enrolls about 15 adults whose cancer has spread and who have already tried standard treatments. The main goals are to see if patients can stick to the diet and to track side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

colorectal adenocarcinoma colorectal cancer colorectal neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Los Angeles General Medical Center

    RECRUITING

    Los Angeles, California, 90033, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Saint Jude Medical Center / Providence Medical Foundation

    RECRUITING

    Fullerton, California, 92835, United States

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • USC / Norris Comprehensive Cancer Center

    RECRUITING

    Los Angeles, California, 90033, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••