Sun Yat-sen University

This study tests a combination of three drugs (chidamide, toripalimab, and anlotinib) in adults with advanced nasopharyngeal cancer that has not responded to at least one prior treatment. The goal is to find the safest dose and see if the combination can shrink tumors. About 52 p…

This study tests a new pre-mixed fluid that contains phosphate for ICU patients needing continuous kidney dialysis (CRRT). Standard fluids can wash out phosphate, causing muscle weakness and breathing problems. The trial will compare the new fluid to standard fluid in 220 adults …

This study tests whether adding chemotherapy to immunotherapy works better than immunotherapy alone for people with advanced nasopharyngeal cancer whose cancer did not fully respond to initial treatment. About 516 adults aged 18-65 with stage II-III disease will receive either th…

This study tests a new way to deliver radiation for gastric MALT lymphoma. Using AI, the treatment adapts each session to better protect nearby organs. About 25 adults with early-stage disease will take part. The goal is to see if this approach is safe and effective.

This phase 3 trial tests whether adding the drug anlotinib to standard chemoradiotherapy and immunotherapy can improve outcomes for people with high-risk nasopharyngeal cancer. About 412 adults aged 18-65 with advanced-stage disease will be randomly assigned to receive either the…

This study tests whether a new drug called teprotumumab works better than standard steroid treatment after emergency eye surgery for people with thyroid eye disease that has damaged the optic nerve. About 60 adults aged 18 to 65 will be randomly assigned to receive either teprotu…

This study tests two short pre-surgery treatments for people with advanced head and neck cancer that can be removed. Half get an immunotherapy drug (toripalimab) alone, the other half get toripalimab plus two rounds of chemotherapy. After treatment, everyone has standard surgery …

This study tests a new drug, sacituzumab tirumotecan, in 38 people with advanced thymic epithelial tumors that have worsened after at least one prior treatment. The drug is an antibody-drug conjugate designed to target and kill cancer cells. The goal is to see if it can shrink tu…

This study tests whether a combination of three drugs (tirzepatide, empagliflozin, and pioglitazone) can help people newly diagnosed with type 2 diabetes achieve remission better than standard metformin-based therapy. About 296 adults will take the triple combo or standard treatm…

This study compares giving chemotherapy before surgery versus standard surgery-first treatment for adults aged 18-70 with stage II or III colon cancer and high CEA levels. One hundred participants will be randomly assigned to either four cycles of CAPEOX chemo followed by surgery…

This study tests whether adding two immunotherapy drugs (PD-1 antibody and anlotinib) to standard chemotherapy and radiation can help people with high-risk advanced nasopharyngeal carcinoma live longer without their cancer growing. About 442 adults aged 18-65 with stage III disea…

This study tests a new combination of three drugs (sintilimab, pegaspargase, and selinexor) followed by radiation as a first treatment for people newly diagnosed with stage I or II extranodal NK/T-cell lymphoma, a rare blood cancer. About 47 adults will receive the drug combo fir…

This study tests a chemotherapy-free combination of three drugs (sonrotoclax, zanubrutinib, and rituximab) in 52 adults with previously untreated follicular lymphoma. The goal is to see if this approach can produce deeper and longer-lasting remissions while being easier to tolera…

This study looks at 120 adults with advanced hepatitis B-related liver cancer who are also getting immunotherapy. It compares taking one antiviral drug (TAF) alone versus taking two drugs (ETV plus TAF) to see which helps people live longer. The goal is to find the best way to co…

This study looks at children with a rare, severe eye disease called primary congenital glaucoma. It compares three different amounts of a surgery called goniotomy (120°, 240°, or 360°) to see which works best and is safest. The goal is to lower eye pressure and protect vision, bu…

This study tests whether adding the targeted drug fruquintinib to standard chemotherapy works better than chemotherapy alone for people with advanced pMMR endometrial cancer. About 128 participants will receive either the combination or standard treatment. The goal is to see if t…

This study tests a three-drug combination (polatuzumab vedotin, rituximab, and chidamide) in elderly patients (70+ or frail 60-69) with a specific type of aggressive lymphoma called double-expressor DLBCL. The goal is to see if the combination is safe and effective at shrinking o…

This study compares a shorter course of the immunotherapy drug tislelizumab (6 total doses) against a longer course (8 total doses) when given with standard chemoradiotherapy for people with advanced nasopharyngeal cancer. About 418 adults aged 18-65 with stage T4N1 or T1-4N2-3 d…

This study tests whether combining local treatments (TACE or ablation) with immunotherapy drugs (sintilimab and ipilimumab) before surgery can reduce the high risk of liver cancer returning. About 105 adults with resectable liver cancer at intermediate-to-high recurrence risk wil…

This study tests whether adding the anti-inflammatory drug celecoxib to standard chemotherapy (R-CHOP) works better than chemotherapy alone for people with a specific, aggressive type of lymphoma called CD5-positive diffuse large B-cell lymphoma. About 60 adults with newly diagno…

This study tests a three-drug combination for people with a type of liver cancer (intrahepatic cholangiocarcinoma) that cannot be removed by surgery. The treatment includes chemotherapy delivered directly to the liver, a targeted pill, and an immunotherapy drug. The goal is to se…

This study tests whether giving sintilimab (an immunotherapy drug) together with chemotherapy can shrink advanced stage IIIC lung cancer enough to allow surgery. About 33 adults with previously untreated, unresectable non-small cell lung cancer will receive four cycles of the com…

This study tests a combination of three drugs (docetaxel, nimotuzumab, and pucotenlimab) in 30 adults with recurrent or metastatic head and neck cancer that has not responded to previous treatments. The goal is to see if this therapy can shrink tumors and improve survival. Partic…

This study tests a combination of three drugs (lisaftoclax, chidamide, and rituximab) in about 51 adults with diffuse large B-cell lymphoma that has come back or not responded to prior treatment. The goal is to find a safe dose and see if the combo can shrink tumors. Participants…

This study compares two treatments for small liver cancer (a single tumor 5 cm or smaller): surgery to remove the tumor or a precise, high-dose radiation therapy called SBRT. About 312 adults aged 18-75 will be randomly assigned to one of the two treatments. The main goal is to s…

This study tests whether nintedanib, a drug that reduces scar-like tissue, can improve the chance of a live birth for women with adenomyosis who have frozen embryos. About 328 women will receive either standard hormone therapy plus nintedanib or hormone therapy alone for three mo…

This study tests a drug called ivonescimab given for one year after standard chemoradiation in people with stage III lung cancer that cannot be removed by surgery. The goal is to see if it can delay cancer growth. About 63 adults aged 18–75 who have not gotten worse after chemora…

This study tests a new treatment for people whose nose and throat cancer has returned and cannot be removed with surgery. The treatment combines an immunotherapy drug (PD-1 antibody) with two chemotherapy drugs, followed by targeted radiation. The goal is to see if this approach …

This study tests a new approach for people with early-stage non-small cell lung cancer that can be surgically removed. Instead of standard chemotherapy, participants will receive a combination of targeted radiation (SBRT), an immunotherapy drug (tislelizumab), and an antiangiogen…

This study tests a new drug, zeprumetostat, combined with other treatments for people whose T-cell or NK-cell lymphoma has come back or stopped responding to therapy. The goal is to find safe doses and see if the combination shrinks tumors. About 60 adults will take part in this …

This study tests two drugs, adebrelimab and SHR2554, together in about 40 adults whose T-cell lymphoma has come back or not responded to treatment. The goal is to find a safe dose and see if the combination can shrink tumors. Participants must have certain types of T-cell lymphom…

This study tests whether giving two drugs (becotatug vedotin and pucotenlimab) before surgery can shrink tumors in people with recurrent head and neck cancer that has stopped responding to standard treatments. About 42 adults with EGFR-positive cancer will receive 3 cycles of the…

This study tests whether adding a drug called adebrelimab to standard radiotherapy and chemotherapy can help shrink tumors in people with a certain type of advanced rectal cancer. About 84 adults aged 18-75 will take part. The goal is to see if the cancer disappears completely be…

This study tests whether adding two immunotherapy drugs (tislelizumab and surufatinib) to standard chemoradiation can help people with stage III non-small cell lung cancer that cannot be surgically removed. About 160 participants will be randomly assigned to receive either the tw…

This study tests whether a new combination of drugs (trifluridine/tipiracil plus fruquintinib) works as well as the current standard (trifluridine/tipiracil plus bevacizumab) for people with advanced colorectal cancer that has not responded to at least two prior treatments. About…

This study tests whether adding lubiprostone, a drug used for constipation, to standard maintenance therapy can delay cancer recurrence in adults with colorectal cancer that has spread to the lining of the abdomen. About 124 participants who have had surgery to remove visible tum…

This study tests whether combining surufatinib, toripalimab, and chemotherapy before surgery can help people with high-risk or borderline resectable pancreatic cancer live longer without the cancer coming back. About 30 adults aged 18-75 will receive the treatment for up to 8 cyc…

This study tests whether adding trilaciclib to the chemotherapy drug eribulin can protect the bone marrow in people with advanced triple-negative breast cancer who have already tried at least two other chemotherapies. The goal is to reduce serious side effects like low white bloo…

This study looks at whether giving radiation therapy after surgery can help prevent adrenal cancer from returning in patients with high-risk localized adrenocortical carcinoma. About 58 patients who had their tumor completely removed will be randomly assigned to either receive ra…

This study tests a combination of three drugs (disitamab vedotin, tunlametinib, and a PD-1 antibody) in people with advanced stomach cancer that has a specific protein (HER2) and has not responded to at least two prior treatments. The goal is to see if the combo can shrink tumors…

This study tests if temporarily restricting blood flow to an arm (called ischemic preconditioning) before kidney cancer surgery can reduce kidney damage. About 174 adults having partial nephrectomy will be randomly assigned to receive this technique or standard care. The goal is …

This study tests a combination of two drugs, SHR-A1811 and ivonescimab, in 30 adults with advanced non-small cell lung cancer that has HER2 abnormalities. The goal is to see if the treatment can slow or stop cancer growth. Participants must have tried at least one prior therapy o…

This phase 2 trial tests a combination therapy with tunlametinib for people with advanced non-small cell lung cancer that has a KRAS mutation and has not responded to other treatments. The study will enroll 55 adults to see if the drug combo can shrink tumors and control the dise…

This study will test a medicine called faricimab for people with wet age-related macular degeneration (nAMD), a common cause of vision loss. About 50 adults aged 50 and older who have not been treated before will receive four initial injections, then more as needed. The goal is t…

This study tests whether adding a targeted drug (Becotatug Vedotin) to standard immunotherapy and chemoradiation can better control high-risk nasopharyngeal cancer. About 514 adults with advanced disease will be split into two groups to compare the new combo against the usual tre…

This study tests a new flexible sheath (ArcFlex) used during TAVR, a procedure to replace a diseased aortic heart valve without open-heart surgery. The sheath helps guide the new valve into place, and researchers want to see if it improves success rates. About 180 people who need…

This study tests a combination of two drugs (trastuzumab Rezetecan and ivonescimab) in 30 people with advanced non-small cell lung cancer that has HER2 gene changes. The goal is to see if the combination can shrink tumors or delay cancer growth. Participants must be 18-75, in goo…

This study tests a new drug combination (goselasib plus other drugs) as a first treatment for people with advanced lung cancer that has a specific gene change called KRAS G12C. About 69 adults will take part to see if the combo shrinks tumors and how long that effect lasts. The g…

This study tests a three-drug combination (sintilimab, chidamide, and azacitidine) as a first treatment for people with early-stage extranodal NK/T-cell lymphoma, a rare blood cancer. About 30 participants will receive the drugs, followed by radiation therapy if needed. The goal …

This study tests whether adding entinostat to fulvestrant can help control advanced breast cancer in people whose disease has worsened after standard hormone therapy and CDK4/6 inhibitors. About 50 women aged 18-75 with HR+/HER2- cancer will receive the combination. The main goal…

This study tests a new chemotherapy combination (FOLFOX8) against a standard one (mFOLFOX6) for people with advanced colorectal cancer that cannot be removed by surgery. About 229 adults will receive one of these treatments along with targeted drugs. The goal is to see if the new…

This study tests a new treatment for people with advanced digestive tract cancers that cause fluid buildup in the belly (malignant ascites) after standard treatments have stopped working. The treatment combines a modified protein (rmhTNF-NC) injected into the belly, an immunother…

This study tests if adding a common heart medication (propranolol) to standard chemotherapy and immunotherapy before surgery can improve outcomes for people with a certain type of colon cancer. About 45 adults with stage II or III colon cancer that is mismatch repair proficient (…

This study tests a combination of two drugs, QL1706 and anlotinib, for people with advanced small cell lung cancer who have already tried at least two prior treatments. The goal is to see if the combination helps control the cancer and extends survival. About 120 adults aged 18 t…

This study tests a new treatment plan for people with a certain type of locally advanced rectal cancer (pMMR/MSS). Participants first get a short course of radiation, then a combination of an immunotherapy drug (QL1706) and chemotherapy. The goal is to shrink or eliminate the tum…

This study tests a new treatment approach for people with high-risk locally advanced rectal cancer. It combines a short course of radiation (with a higher dose to the tumor) with chemotherapy and an immunotherapy drug before surgery. The goal is to see if this combination can mak…

This study tests whether a minimally invasive heart valve repair procedure (TEER) plus standard medication can reduce hospital readmissions over two years in people with moderate mitral regurgitation that worsens with exertion. About 300 participants will be randomly assigned to …

This study tests whether a combination of two drugs (hetrombopag and rhTPO) works better than hetrombopag alone to raise dangerously low platelet counts caused by cancer treatments like chemotherapy. About 204 adults with solid tumors and severe low platelets will be randomly ass…

This study tests whether giving a precise form of radiation (SBRT) along with chemotherapy and immunotherapy before surgery can help people with advanced mouth or throat cancer live longer without the cancer coming back. About 184 adults with untreated, advanced oral or HPV-negat…

This study tests a new treatment for people whose nasopharyngeal cancer has come back and cannot be removed with surgery. Participants will receive two cycles of a targeted drug (becotatug vedotin) plus an immunotherapy (PD-1 inhibitor), followed by radiation and continued immuno…

This early-phase study tests a personalized cell therapy (TCR-T) in 25 adults with advanced solid tumors caused by KRAS mutations. Participants must have exhausted standard treatments. The goal is to see if the therapy is safe and can shrink tumors. This is not a cure, as ongoing…

This study tests whether adding the experimental drug lisatoclax to standard chemotherapy (R-CHOP or Pola-R-CHP) can safely improve outcomes for people with untreated diffuse large B-cell lymphoma (DLBCL). About 122 adults aged 18-70 will take part. The goal is to see if the comb…

This study tests whether combining two drugs, scipibaimab and tislelizumab, can shrink tumors in people with advanced nasopharyngeal carcinoma (a type of nose and throat cancer) that has come back or spread and stopped responding to standard first treatment. About 37 adults aged …

This study tests whether a stronger chemotherapy combination (Chinese modified FOLFOXIRI) plus an immunotherapy drug (PD-1 inhibitor) works better than standard chemotherapy (mFOLFOX6) before surgery for people with locally advanced colon cancer (stage II high-risk or stage III).…

This phase 3 trial tests whether adding an immunotherapy drug (PD-1 antibody) to a strong chemotherapy and radiation regimen works better than standard chemo plus radiation for people with a certain type of advanced rectal cancer. About 382 adults will be randomly assigned to one…

This study tests whether a single spinal injection of morphine, given before open abdominal surgery, can improve how well patients recover. It involves 756 adults scheduled for surgery and compares the injection to a placebo. The goal is to see if this approach reduces pain and s…

This study tests whether megestrol acetate, a drug often used for appetite loss, can prevent or reduce severe tiredness in 132 women with advanced breast cancer who are starting a treatment called trastuzumab deruxtecan (T-DXd). Participants will receive either megestrol acetate …

This study tests whether adding a spinal injection of morphine to a standard abdominal wall nerve block improves recovery after laparoscopic gynecologic surgery. About 252 women scheduled for such surgery will be randomly assigned to receive either the combination or the nerve bl…

This study tests whether taking taurine can prevent or reduce severe mouth sores caused by radiation therapy in people with nasopharyngeal cancer. About 130 adults will be randomly assigned to receive taurine or standard care during their radiation treatment. The goal is to see i…

This study tests whether simple nudges like text message reminders, a medication calendar, and a personal action plan can help people with atrial fibrillation stick to their blood thinner medication. Researchers will compare 84 participants who receive these nudges to those who g…

This study compares two methods of lifting the soft palate during throat surgery to see which causes fewer injuries. About 138 people aged 2 to 70 who need this type of surgery will take part. The new method uses a full-wrap suspension instead of the traditional double-strap appr…

This study tests a 12-week home-based exercise program combining aerobic and resistance training for older adults (60+) with type 2 diabetes and early signs of muscle weakness (probable sarcopenia). The goal is to see if short, manageable workouts can increase daily physical acti…

This study will interview 30 college students who show signs of short-video addiction to understand why they get hooked and how it affects them. Researchers will use two psychological theories to analyze the students' experiences, including what triggers the behavior and how it i…

This study will use a special type of eye scan (ultra-widefield OCTA) to measure blood vessel patterns in people with central serous chorioretinopathy (CSC), a condition that causes fluid buildup and blurry vision. Researchers aim to create a more precise way to analyze these ima…

This study compares two ways of growing embryos in the lab during IVF: a traditional method versus a new system that keeps embryos undisturbed. About 478 women undergoing IVF will have their eggs randomly split between the two methods. The goal is to see if the new system leads t…

This study will develop an artificial intelligence model to predict how well patients with a rare type of lymphoma (NK/T-cell) respond to their first chemotherapy. Researchers will collect medical images and tissue samples from 100 participants to train the AI. The goal is to hel…

This study looks at whether new blood tests can find tiny bits of cancer DNA left after surgery in people with stage III colorectal cancer. About 229 patients will give blood samples, which will be analyzed using two different methods. The goal is to see which test better predict…

This study looks at how the amount and type of carbohydrates you eat affect your blood sugar, cholesterol, and gut bacteria. Researchers will give 20 adults with or at risk for metabolic syndrome different carb diets to see what changes. The goal is to learn which carb choices ar…

This study looks at how new mothers' feelings about their bodies and social media use relate to postpartum depression. About 385 women who gave birth in the past 4 weeks to 12 months will answer online surveys. The goal is to understand these connections, not to test a treatment.

This study tests a new approach called 'Flipped Discharge' for people with colorectal cancer who have a stoma after surgery. Instead of focusing care in the hospital, it shifts support to the home, with a nurse visit or video follow-up three days after discharge. The goal is to s…