New hope for hard-to-treat head and neck cancer: drug combo before surgery shows promise

NCT ID NCT07589049

Not yet recruiting Disease control Sponsor: Sun Yat-sen University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether giving two drugs (becotatug vedotin and pucotenlimab) before surgery can shrink tumors in people with recurrent head and neck cancer that has stopped responding to standard treatments. About 42 adults with EGFR-positive cancer will receive 3 cycles of the drug combo, then surgery, followed by more therapy. The main goal is to see how many patients have a major reduction in tumor cells after the drugs.

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Conditions

The condition(s) this trial relates to.

Head and Neck Neoplasms head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEAD AND NECK SQUAMOUS CELL CARCINOMA

Contacts and locations

Locations

Affiliated Hospital of Guangdong Medical University

Zhanjiang, Guangdong, China
Cancer Hospital of Guangzhou Medical University

Guangzhou, Guangdong, China
Cancer Hospital of Shantou University Medical College

Shantou, Guangdong, China
Ganzhou Cancer Hospital

Ganzhou, Jiangxi, China
Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China
Guangzhou First People's Hospital

Guangzhou, Guangdong, China
Qingyuan People's Hospital

Qingyuan, Guangdong, China
Shenzhen Second People's Hospital

Shenzhen, Guangdong, China
Sun Yat-sen University Cancer Center

Guangzhou, Guangdong, China
The First People's Hospital of Foshan

Foshan, Guangdong, China
The Third Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, China
Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, China

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