LOW BACK PAIN

This study tests whether adding a bone-marrow concentrate injection during routine back surgery helps the spinal disc heal better. About 90 adults with a herniated disc will get either surgery alone or surgery plus the injection. Researchers will use MRI scans and pain questionna…

This study looks at whether core exercises or functional strength exercises can help prevent low back and neck pain in healthy women. Researchers will compare two exercise programs in 45 women who do not currently exercise regularly. The goal is to find out which approach is bett…

This study looks at two ways to help people recover after surgery for a slipped disc in the lower back. One group will start moving early, and the other will do the same plus get mild electrical stimulation on their muscles. The goal is to see which approach reduces pain and impr…

This trial investigates whether a device called Neurolyser XR can safely ease low back pain caused by sacroiliitis (inflammation of the joint at the base of the spine). The device uses high-intensity focused ultrasound to block pain signals from the joint, without needles or cutt…

This Phase 2 trial tests an oral drug called LY4065967 in 150 people with chronic low back pain lasting at least 3 months. Half will get the drug, half a placebo, to see if it safely reduces pain and improves daily function. The study is not yet recruiting.

This study tests whether teaching people about how pain works (pain neuroscience education) combined with spinal manipulation helps those with chronic low back pain feel more in control of their health. 74 adults with long-lasting back pain will be split into two groups: one gets…

This pilot study tests two simple, at-home techniques—foam rolling and nerve sliding—to see which better improves hamstring flexibility in 30 adults with tight hamstrings and a history of low back pain. Participants will try both methods on different days, with a month break in b…

This study tests whether training the sense of touch can reduce pain and improve daily function in people with chronic low back pain. 66 adults aged 25-45 with persistent pain will be split into three groups: device-based training, manual training, or standard physical therapy. T…

This study looks at whether a gentle stretching technique called neural mobilization can immediately improve balance and body awareness in people with low back pain that also travels down the leg. Researchers will compare the nerve stretch to a fake (sham) version in 52 adults. T…

This study will track 600 adults with neck or back pain who are already scheduled to receive pharmacopuncture (herbal medicine injections) as part of their care. The key difference is that doctors will use an ultrasound device to guide the needle, aiming to avoid nerves and blood…

This study looks at whether a program of lumbar spine correction training can improve postural awareness and stability in adults aged 25 to 45 who have had low back pain for more than 6 months. Thirty participants will be split into two groups: one doing the special exercises plu…

This pilot study will test whether adding high-intensity laser therapy to a hands-on technique called Mulligan mobilization can reduce pain and improve movement in people with chronic low back pain. Fifty adults aged 18-60 will be split into two groups: one gets the combo treatme…

This study looks at how yoga nidra (a guided relaxation practice), yoga, and a control condition affect pain and movement in people with chronic low back pain. Twenty-seven adults with long-term back pain will try each approach on separate visits and rate their pain during heat t…

This study tests whether supervised water-based exercise (aquatherapy) can improve physical performance, balance, and fear of falling in adults aged 65 and older with chronic low back pain. Forty-five participants will be randomly assigned to either aquatherapy or standard land-b…

This study looks at two hands-on treatments—kinesio taping and myofascial release—to see which works better for low back pain during periods. About 44 healthy young women aged 18-25 with regular cycles and moderate to severe pain will take part. The goal is to find a safe, drug-f…

This study tests an 8-week exercise program that combines core and gluteal strengthening to reduce pain and improve daily function in people with chronic low back pain. Researchers will enroll 54 adults aged 18-65 who have had non-specific low back pain for at least 3 months. The…

This study tests if injecting a sugar-water solution into the lower back, guided by ultrasound, can safely reduce chronic pain in people with hypermobile Ehlers-Danlos syndrome (hEDS). About 40 adults with hEDS and low back pain will receive the injections and report their pain l…

This study tests whether a single session of sleep hygiene education can improve sleep quality and reduce pain in 100 adults with migraine or chronic lower back pain. Participants will learn healthy sleep habits and follow them for four weeks, tracking changes through questionnai…

This study looks at how common neck and low back pain is among nursing students at the University of the West Indies, and tests whether a spine-specific exercise program works better than general exercises to ease that pain. About 400 students with pain will be randomly assigned …

This study compares two treatments—post-facilitation stretching and dry needling—for people with chronic low back pain and tight hamstrings. About 36 adults aged 20-50 will receive one of the treatments three times a week for three weeks. The goal is to see which approach better …

This study looks at whether adding gentle electrical muscle stimulation (EMS) to body awareness exercises can reduce pain and improve daily function in people with non-specific low back pain. About 72 adults aged 18-65 with at least 3 months of back pain will be randomly assigned…

This study tests a new early rehabilitation program for people who have had lumbar spinal fusion surgery for low back pain. The program combines conversation-based education with graded physical activity, starting two weeks after surgery. Researchers will include 12 participants …

This study tests whether a 6-week exercise program, added to usual pain medication, can reduce disability and pain in adults aged 60 and older with chronic low-back pain and signs of back muscle degeneration. About 314 participants will be randomly assigned to either the exercise…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests whether thread-embedding acupuncture (TEA) helps adults with chronic low back pain more than a sham version. Thirty-two participants will receive one session of either TEA or a fake procedure and be followed for 8 weeks. Researchers will measure pain levels, qual…

This study looks at whether Downward-Facing Dog yoga can reduce pain and improve posture in children aged 8 to 14 with non-specific low back pain. The approach is a fun, non-invasive alternative to traditional physiotherapy. Researchers will measure posture using a plumb line and…

This study will test whether adding a breathing muscle trainer to aerobic exercise helps adults with obesity and chronic low back pain. Forty-eight participants will be split into two groups: one using the trainer at a low resistance and one at a higher resistance. Researchers wi…

This pilot study tests whether simply imagining doing back extension exercises can reduce pain and improve movement in 40 adults with chronic low back pain who prefer extension. Participants will lie down and mentally rehearse press-up movements guided by a script. The study meas…

This study tests whether adding sensory discrimination training to pain neuroscience education and core exercises can reduce pain catastrophizing and fear of movement in 80 adults with chronic low back pain. Participants will attend sessions twice a week for eight weeks. The goal…

This study looks at whether adding a gentle vibration to dry needling can reduce low back pain better than dry needling alone. About 36 adults with long-term low back pain will receive either standard dry needling or dry needling with vibration. The goal is to see if the vibratio…

This study will test whether a single 20-minute hot-pack session can immediately reduce pain and muscle stiffness in adults with low back pain. Twenty-four participants will be randomly assigned to receive either a real hot pack or a room-temperature sham pack. Researchers will m…

This study looks at whether a single 20-minute session of TENS (a device that sends mild electrical pulses through the skin) can immediately reduce muscle stiffness and pain in people with long-lasting low back pain. About 24 adults aged 18–30 with non-specific low back pain will…

This study tests a gentle exercise method called global postural reeducation in 30 housewives aged 25-40 who have had low back pain for over 3 months. The goal is to see if it can reduce pain, lower stress, and improve sleep quality. Unlike painkillers, this approach focuses on r…

This study tests a modified bird-dog exercise, called the Multifidus Lift, in 40 university students aged 18-25 with nonspecific low back pain. Participants do the exercise twice weekly for 6 weeks. Researchers measure back endurance, pain, and disability to see if this low-cost …

This study tests whether pressing on a trigger point in the psoas muscle (a deep hip flexor) can quickly reduce pain and improve movement in 40 young adults (ages 18–30) who have had low back pain for less than a month. Half will get the real pressure technique; the other half wi…

This study tests whether virtual lifestyle-focused pain care works as well as in-person care for adults with chronic back, knee, or hip pain living in rural areas. Participants will receive up to 10 sessions over six months, either in-person with a physiotherapist or virtually wi…

This study reviews medical records of 120 adults with low back pain who completed 15 sessions of physical therapy. Researchers will group patients based on their MRI results (disc herniation, disc degeneration, or normal findings) to see if certain types of back pain respond bett…

This study follows 300 adults with combat-related lower limb amputations to see how the level of amputation (below knee, above knee, or both legs) relates to chronic low back pain. Researchers will measure pain intensity, disability, and rehabilitation progress over time. The goa…

This study explores how a special mat with sensory bumps can change brain activity in people with chronic low back pain. Researchers will scan the brains of 20 patients and 20 healthy volunteers while they lie on the mat. The goal is to see if the mat can help restore the brain's…

This study looks at 96 adults with lower back pain to see if the damage shown on an MRI matches how much pain they actually feel. Participants will fill out pain and disability questionnaires and get a physical exam. The goal is to help doctors better understand and treat back pa…

This study looks at how a deep core muscle (transversus abdominis) changes in people with chronic low back pain and whether those changes affect arm reach and shoulder stability. Researchers will compare 90 adults with and without back pain using ultrasound and simple movement te…

This two-phase study first measures how common neck and low back pain is among physical therapy students at the University of the West Indies, Mona. Then, students with pain are randomly assigned to either an eight-week spine-specific exercise program or a general exercise progra…

This study looks at how common neck and low back pain is among full-time staff at the University of the West Indies, Mona. It also tests whether an eight-week spine-specific exercise program reduces discomfort better than a general exercise program. About 200 staff members will t…

This study will compare how massage and talk therapy affect stress and bonding hormones (cortisol and oxytocin) in people with chronic neck or back pain. Twenty-five adults with pain lasting at least 3 months will try both treatments in random order. Researchers will measure horm…

This study looks at how the curve of the lower spine relates to knee angle in college students who are addicted to their smartphones and have long-term low back pain. Researchers will measure spine curvature and knee movement using video software. The goal is to understand these …

This study looks at how smartphone addiction relates to core muscle endurance, spine curvature, and daily function in university students aged 18-25 who have had chronic low back pain for at least six months. Researchers will measure addiction levels, muscle endurance, and disabi…

This study will measure balance in 80 people with three types of chronic low back pain: lumbar spondylosis, spondylolisthesis, and disc prolapse. Participants will stand on a special platform (Biodex Balance System) under different conditions, like with eyes open or closed, to se…

This study compares spinal movement patterns between 40 people with chronic low back pain and those without pain. Participants perform movements while receiving different visual cues, and their spine angles are measured in a single session. The goal is to understand how pain chan…

This study tests whether doing sit-to-stand exercises with a blood flow restriction cuff on the thigh can improve back muscle endurance and balance more than the same exercises without the cuff. Seventy healthy young adults aged 20-25 will exercise twice a week for six weeks. Res…

This study will translate and test a Turkish version of the Usefulness, Satisfaction, and Ease of Use (USE) Questionnaire in 220 adults with chronic back or neck pain who have used a biomedical device. The goal is to ensure the questionnaire is culturally appropriate and scientif…