Sound waves instead of needles: new device targets back pain without piercing skin

NCT ID NCT07647757

Not yet recruiting Symptom relief Sponsor: Federico II University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether a device called Neurolyser XR can safely ease low back pain caused by sacroiliitis (inflammation of the joint at the base of the spine). The device uses high-intensity focused ultrasound to block pain signals from the joint, without needles or cutting the skin. About 30 adults with long-term sacroiliac joint pain will receive the treatment, and researchers will measure changes in pain levels.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: high intensity focused ultrasound (Neurolyser XR device)
What this could lead to: If it works, this could offer a needle-free, low-discomfort option for people with chronic low back pain from sacroiliitis.
What could go wrong: This is a small, early-stage study with only 30 participants. The device may not provide lasting pain relief, and risks like unintended tissue damage are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

arthritis, sacroiliac Low Back Pain Sacroiliitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LOW BACK PAIN SACROILIITIS

Contacts and locations

Locations

Department of Neuroscience, Reproductive and Odontostomatological Sciences

Naples, 80131, Italy

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