CYSTIC FIBROSIS

This study is testing a new three-drug combination therapy for children aged 1 to 11 years old who have cystic fibrosis. The main goals are to see how the drugs move through the children's bodies, check if the treatment is safe, and look for early signs that it might help control…

This early-stage study is testing a new inhaled medication called RCT2100 for people with cystic fibrosis. The research will first check if the treatment is safe in healthy volunteers, then test it in people with CF who cannot use current standard medications. The goal is to see …

This study is testing a new inhaled medication called ARCT-032 for adults with cystic fibrosis who cannot use standard CFTR modulator drugs. Participants will use the inhaler daily for 4 weeks while researchers monitor safety and check if it improves lung function and quality of …

This study aims to find effective treatments for people with rare cystic fibrosis gene mutations. Researchers will test existing CF drugs on patients' own nasal cells in the lab, then conduct personalized trials to see if those drugs help improve breathing. The goal is to match i…

This early-stage study is testing a new drug called VX-522 in adults with cystic fibrosis (CF) who have genetic mutations that don't respond to current CFTR modulator therapies. The main goals are to check if the drug is safe and tolerable, and to see if it improves lung function…

This early study is testing whether three existing cystic fibrosis drugs (Symdeko, Orkambi, and Kalydeco) might help patients who have rare genetic mutations that aren't currently approved for these treatments. Researchers will give 20 participants the drug that lab tests suggest…

This study follows people with cystic fibrosis who had to stop or change their previous treatment due to mental health issues or liver problems. Researchers want to see if a newer triple therapy medication is safer for these patients. They'll monitor 200 participants for one year…

This study is testing two different approaches for treating lung flare-ups in children with cystic fibrosis. One approach starts antibiotics immediately, while the other waits to see if symptoms worsen first. The goal is to see if the 'wait-and-see' method can control the disease…

This study aims to understand how different hormone treatments affect bone health in young women with cystic fibrosis (CF). Researchers will observe some participants and test estrogen skin patches in others to see if they improve bone density and quality of life. The study invol…

This early-stage study aims to check the safety and how the body processes a new drug called VX-828. It will test VX-828 alone and in combinations with other CF medications in 255 healthy volunteers and people with cystic fibrosis. The main goal is to see if the drug is safe and …

This study is testing if a structured diet and exercise program can help adults with cystic fibrosis build more muscle. It is for people who are already taking a modern drug therapy (Elexacaftor-Tezacaftor-Ivacaftor). Researchers want to see if this combined lifestyle program imp…

This study is observing adults with cystic fibrosis who have ongoing sinus problems. It aims to see if sinus surgery helps more than medication alone. Researchers will track changes in lung function, hospital stays, and quality of life over time.

This study is testing a new smartphone app called AWARE that uses your phone's microphone and speakers to listen to your breathing. The goal is to see if it can accurately help doctors diagnose lung diseases like asthma and COPD, and spot when symptoms are getting worse. Research…

This study is testing whether sputum (mucus) samples collected at home and mailed to a lab are as good as samples collected in a clinic for detecting lung infections in adults with cystic fibrosis (CF). It aims to make infection monitoring easier and more accessible, especially a…

This study is testing if a small, wearable glucose sensor can be used instead of the standard, lengthy annual test to screen for diabetes in adults with cystic fibrosis. About 30 participants will wear the sensor for 10 days and compare its results to the current standard test. T…

This study is evaluating a new, non-invasive blood test to diagnose serious inherited genetic disorders in unborn babies. The test analyzes tiny bits of the baby's DNA found in the mother's blood, aiming to provide a safe and accurate diagnosis as early as 9 weeks into pregnancy.…

This study is testing a new, low-cost sweat sensor that sticks to the skin to diagnose cystic fibrosis. Researchers will compare this new device to the current standard sweat test in 30 adults, including both people with CF and healthy volunteers. The goal is to create a simpler,…

This study is testing two new types of MRI scans that use safe, inhaled gases instead of radiation to create detailed pictures of the lungs. Researchers want to see if these scans can detect changes in lung structure and function in people with cystic fibrosis or asthma more clea…

This study is testing whether a medication called tenapanor, already approved for IBS with constipation, can help relieve constipation in people with cystic fibrosis. Twenty-five participants will take the drug twice daily for four weeks while tracking their bowel movements and s…

This study aims to learn more about bronchiectasis, a lung condition that causes repeated infections and breathing problems. Researchers will follow 900 patients and some of their family members over time, collecting health information and samples like blood and sputum. The goal …

This is a very early study to check if a new drug called VX-581 is safe and how it moves through the body. It involves 128 healthy volunteers who will receive either the drug or a placebo. The main goal is to understand the drug's safety profile and how the body processes it befo…

This study aims to understand how genes contribute to the development of various lung diseases, including cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will collect genetic information from up to 3,500 participants, including people with these conditions and health…

This study aims to understand if new, highly effective CF medications improve sinus health and the sense of smell in young children with cystic fibrosis. Researchers will follow 80 children, aged 2 to 8, for two years. They will compare kids taking the new medications to those wh…

This study aims to better understand how a specific gene (CFTR) is controlled in cells of the male reproductive tract. Researchers will use small tissue samples collected during scheduled surgeries from men with infertility, cystic fibrosis, or a related condition. The goal is to…

This study aims to help people with rare cystic fibrosis (CF) mutations who can't join current drug trials. Researchers will collect blood, nasal, and intestinal cells from 500 participants. These cells will be used in the lab to test whether future CF treatments might work for t…

This study aims to understand why teenagers with cystic fibrosis (CF) often develop weaker bones. Researchers will compare 36 teens with CF to 36 healthy teens, using knee MRI scans, bone density tests, and blood work over one year. The goal is to see if increased fat in the bone…

This study aims to better understand different patterns in chronic lung diseases like asthma, COPD, and cystic fibrosis. Researchers will observe 470 patients over 10 years, collecting detailed health information without testing new treatments. The goal is to identify disease sub…

This study aims to create better, safer ways to test exercise in children with chronic health conditions. Researchers will follow 240 children and teens with cystic fibrosis, sickle cell disease, or long-term effects from COVID-19 over several years. They will measure how their b…

This study aims to understand why people with cystic fibrosis often develop diabetes. Researchers are testing how the pancreas in CF patients responds to specific hormones that normally help produce insulin. The study involves adults with cystic fibrosis and healthy volunteers to…

This study aims to understand how much physical activity adults with cystic fibrosis get and how much time they spend sitting. Researchers will observe 270 patients to identify those with inactive lifestyles who might face greater health risks. The goal is to gather information t…

This study aims to better understand how lung function changes over time in adults with cystic fibrosis. Researchers will use a special MRI technique that involves breathing in a safe contrast gas to create detailed pictures of how air moves through the lungs. Participants will h…

This study aims to understand how noncirrhotic portal hypertension (NCPH) develops and progresses over many years. Researchers will follow 400 people aged 12 and older who either have NCPH or are at risk for it due to other conditions like cystic fibrosis. The study involves regu…

This study aims to understand how approved cystic fibrosis (CF) modulator treatments affect the body's biological markers and patient health in real-world use. It will follow 500 people with CF in Germany for one year, measuring changes in sweat, intestinal function, lung health,…

This study aims to collect health data from 400 people with cystic fibrosis who cannot use current CFTR modulator medications. Researchers will track lung function and quality of life over 12 months to better understand this underserved population. The data will help design futur…

This study aims to learn if new, sensitive MRI scans can detect lung changes in teens with cystic fibrosis when they temporarily stop and then restart their daily airway clearance therapy. Researchers want to see if these scans are better than standard breathing tests at spotting…

This study aims to understand how a specific therapy for cystic fibrosis affects sinus health. Researchers will compare adults with CF who are on the therapy to those who are not, tracking bacteria, inflammation, sense of smell, and quality of life over two years. Participants wi…

This study aims to find out how many adults with cystic fibrosis smoke or vape, as there is very little data on this topic in France. Researchers will survey 100 adults with cystic fibrosis who receive care at a specialized center in Strasbourg. The goal is to gather real-world i…

This study aims to understand how becoming a parent affects the health of people living with cystic fibrosis (CF). Researchers will follow 146 new parents with CF for up to five years, collecting survey data on stress, mental health, and treatment routines, while also tracking th…