CYSTIC FIBROSIS

This study tests whether empagliflozin, a diabetes medication, is safe and tolerable for overweight adults with cystic fibrosis-related diabetes (CFRD). Eight participants will receive either the drug or a placebo, then switch after a break. The goal is to gather early data for a…

This study looks at the long-term safety and effectiveness of the drug combination Trikafta (elexacaftor/tezacaftor/ivacaftor) in people with cystic fibrosis who have certain gene mutations not previously studied. About 300 participants who completed an earlier study will take th…

This study looks at the long-term safety and effectiveness of the drug combination elexacaftor/tezacaftor/ivacaftor (known as Trikafta) in people with cystic fibrosis who are at least 12 months old. Participants must have completed a previous related study. The main goal is to tr…

This study looks at the long-term safety and effectiveness of a triple combination drug (vanzacaftor/tezacaftor/deutivacaftor) for people with cystic fibrosis aged 1 year and older. Participants who completed a previous study will continue taking the medication to monitor side ef…

This study tests the long-term safety and effectiveness of a triple-combination drug (VX-121/tezacaftor/deutivacaftor) in people with cystic fibrosis. About 822 participants who completed earlier studies will take the medication and be monitored for side effects, lung function, s…

This study looks at whether a stool-based test can accurately detect colorectal cancer and precancerous polyps in adults with cystic fibrosis, compared to the standard colonoscopy. About 350 participants will provide stool samples before their routine colonoscopy. The goal is to …

This study looks at whether a strength exercise program can help children and teens with cystic fibrosis who are taking new CFTR modulator drugs. 48 participants will be split into an exercise group and a control group. The goal is to see if exercise can improve muscle strength, …

This study tests if a special website helps people with cystic fibrosis (CF) feel more prepared to discuss lung transplant with their doctors. Many people with CF die without ever considering this option, especially those from marginalized communities. Over 6 months, 132 particip…

This study looks at 17 cystic fibrosis patients in Réunion Island to see if certain types of Achromobacter bacteria cause more lung infections or lead to worse health. Researchers will use a special lab test to identify the bacteria quickly. The goal is to learn which species are…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study uses a new, contrast-free MRI technique to measure blood flow in the lungs of 26 children with cystic fibrosis (CF) and compare it to healthy controls. The goal is to see if blood flow problems occur before or alongside the more commonly measured airway damage. By trac…

This study explores why some people with cystic fibrosis develop severe liver disease while others do not. Researchers are analyzing blood samples and medical records from 154 participants to find "modifier genes" that might influence liver health. The goal is to better understan…

This study tests a special MRI scan that uses inhaled gas to create detailed images of lung function in people with cystic fibrosis. Researchers want to see if this scan can detect early lung changes better than current tests, especially for those on new triple-combination therap…

This study looks at how sweat chloride levels change in people with cystic fibrosis who are taking approved CFTR modulator medicines. Researchers will collect data from about 5,000 patients to see if these changes relate to how well the medicines work in real life. The goal is to…

This study follows 285 pregnant women with cystic fibrosis to see how their lung function changes during pregnancy and for two years after giving birth. Researchers are especially interested in the effects of highly effective CFTR modulators. The goal is to better understand how …

This study was designed to see if a special breathing technique called autogenic drainage could improve how air moves through the lungs of people with cystic fibrosis. The researchers planned to measure lung function before, right after, and two hours after the technique. However…

This study follows 70 babies with cystic fibrosis to see if a germ called Porphyromonas catoniae, measured at 12 months old, can predict if they will get a serious lung infection with Pseudomonas aeruginosa by age 3. Researchers collect sputum and stool samples over time to track…

This study follows 5 people with cystic fibrosis who received a single dose of BI 3720931 gene therapy in an earlier trial. Participants do not receive any new treatment. Doctors will check their health and lung function for up to 15 years to see if the therapy remains safe and e…

This study looks at how CFTR modulators, a type of cystic fibrosis treatment, affect bone strength and muscle mass in adults with CF. Researchers will measure changes in bone density and lean body mass over 12 to 24 months. The goal is to understand whether these treatments help …

This study looks at how different genes can make cystic fibrosis lung disease better or worse in different people. Researchers are studying 600 people with CF to find genetic clues that explain why some have milder lung problems. The goal is to learn more, not to test a new treat…

This study aims to find out how nontuberculous mycobacteria (NTM) — a hard-to-treat lung infection — spreads among people with cystic fibrosis (CF). Researchers will collect dust and water samples from clinics and patients' homes, and map water sources to see if they match the NT…

This study looks at how small blood vessels in the lungs change in people with cystic fibrosis (CF). Researchers will use imaging to measure blood vessel structure in 86 participants aged 5 to 21. The goal is to learn more about how CF affects the lungs over time, not to test a n…

This study involves 300 adults with cystic fibrosis and aims to understand how body composition and muscle strength relate to nutrition and lung function. Researchers will compare simple tests like grip strength and walking distance to a standard body scan. The goal is to find be…

This study tests a new, tiny camera (micro OCT) that can take detailed pictures of the airways in the lungs and nose. Researchers want to see if it works well in adults with cystic fibrosis and healthy volunteers. The goal is to better understand early lung damage, which could le…