New triple therapy for kids with cystic fibrosis shows promise in phase 3 trial
NCT ID NCT05422222
First seen Nov 06, 2025 · Last updated Jun 11, 2026 · Updated 35 times
Summary
This study tests a triple-combination drug (VX-121/tezacaftor/deutivacaftor) in children aged 1 to 11 with cystic fibrosis who have a specific genetic mutation. The goal is to check how the medicine works in the body, its safety, and how well children tolerate it. Around 210 children will take part, and the study also looks at changes in sweat chloride levels, a key marker of CF.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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American Family Childrens Hospital
Madison, Wisconsin, 53792, United States
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Ann & Robert H. Lurie Children's Hospital of Chicago
Chicago, Illinois, 60611, United States
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Boston Children's Hospital
Boston, Massachusetts, 02115, United States
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British Columbia Children's Hospital
Vancouver, Canada
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CHU Lyon - Hopital Femme Mere-Enfant
Bron, France
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Charité - Paediatric Pulmonology Department
Berlin, Germany
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Children and Young Adults Research Unit
Cardiff, United Kingdom
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Children's Hospital of Colorado
Aurora, Colorado, 80045, United States
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Children's Hospital of Orange County
Orange, California, 92868, United States
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Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota
Minneapolis, Minnesota, 55404, United States
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229, United States
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Cohen Children's Medical Center
Lake Success, New York, 11042, United States
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Erasmus Medical Center / Sophia Children's Hospital
Rotterdam, Netherlands
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Great Ormond Street Hospital for Children
London, United Kingdom
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Hopital Necker, Enfants Malades
Paris, France
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Inselspital - Universitaetsspital Bern
Bern, Switzerland
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Karolinska University Hospital - Pulmonology
Stockholm, Sweden
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Kinderspital Zurich
Zurich, Switzerland
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Medizinische Hochschule Hannover
Hanover, Germany
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Nationwide Children's Hospital
Columbus, Ohio, 43205, United States
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Oregon Health & Science University
Portland, Oregon, 97239, United States
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Queensland Children's Hospital
South Brisbane, Australia
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Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center
Cleveland, Ohio, 44106, United States
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Riley Hospital for Children at Indiana University Health
Indianapolis, Indiana, 46202, United States
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Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden
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Stanford University Clinical and Translational Research Unit
Palo Alto, California, 94304, United States
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Starship Children's Hospital
Grafton, New Zealand
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Texas Children's Hospital - Wallace Tower
Houston, Texas, 77030, United States
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The Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
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The Emory Clinic / Children's Healthcare of Atlanta at Egleston
Atlanta, Georgia, 30322, United States
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The Hospital for Sick Children
Toronto, Canada
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The Kids Research Institute Australia
Nedlands, Australia
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The Royal Children's Hospital
Parkville, Australia
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UPMC Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15224, United States
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Universitatsklinikum Essen
Essen, Germany
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Vermont Lung Center
Colchester, Vermont, 05446, United States
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Washington University School of Medicine / St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
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Women's and Children's Hospital
North Adelaide, Australia
Conditions
Explore the condition pages connected to this study.