New triple therapy for kids with cystic fibrosis shows promise in phase 3 trial

NCT ID NCT05422222

Ongoing Disease control Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a triple-combination drug (VX-121/tezacaftor/deutivacaftor) in children aged 1 to 11 with cystic fibrosis who have a specific genetic mutation. The goal is to check how the medicine works in the body, its safety, and how well children tolerate it. Around 210 children will take part, and the study also looks at changes in sweat chloride levels, a key marker of CF.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS

Contacts and locations

Locations

American Family Childrens Hospital

Madison, Wisconsin, 53792, United States
Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois, 60611, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
British Columbia Children's Hospital

Vancouver, Canada
CHU Lyon - Hopital Femme Mere-Enfant

Bron, France
Charité - Paediatric Pulmonology Department

Berlin, Germany
Children and Young Adults Research Unit

Cardiff, United Kingdom
Children's Hospital of Colorado

Aurora, Colorado, 80045, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Respiratory and Critical Care Specialists, P.A., Children's Hospitals and Clinics of Minnesota

Minneapolis, Minnesota, 55404, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Cohen Children's Medical Center

Lake Success, New York, 11042, United States
Erasmus Medical Center / Sophia Children's Hospital

Rotterdam, Netherlands
Great Ormond Street Hospital for Children

London, United Kingdom
Hopital Necker, Enfants Malades

Paris, France
Inselspital - Universitaetsspital Bern

Bern, Switzerland
Karolinska University Hospital - Pulmonology

Stockholm, Sweden
Kinderspital Zurich

Zurich, Switzerland
Medizinische Hochschule Hannover

Hanover, Germany
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Oregon Health & Science University

Portland, Oregon, 97239, United States
Queensland Children's Hospital

South Brisbane, Australia
Rainbow Babies and Children's Hospital/University Hospitals Cleveland Medical Center

Cleveland, Ohio, 44106, United States
Riley Hospital for Children at Indiana University Health

Indianapolis, Indiana, 46202, United States
Sahlgrenska Universitetssjukhuset

Gothenburg, Sweden
Stanford University Clinical and Translational Research Unit

Palo Alto, California, 94304, United States
Starship Children's Hospital

Grafton, New Zealand
Texas Children's Hospital - Wallace Tower

Houston, Texas, 77030, United States
The Children's Mercy Hospital

Kansas City, Missouri, 64108, United States
The Emory Clinic / Children's Healthcare of Atlanta at Egleston

Atlanta, Georgia, 30322, United States
The Hospital for Sick Children

Toronto, Canada
The Kids Research Institute Australia

Nedlands, Australia
The Royal Children's Hospital

Parkville, Australia
UPMC Children's Hospital of Pittsburgh

Pittsburgh, Pennsylvania, 15224, United States
Universitatsklinikum Essen

Essen, Germany
Vermont Lung Center

Colchester, Vermont, 05446, United States
Washington University School of Medicine / St. Louis Children's Hospital

St Louis, Missouri, 63110, United States
Women's and Children's Hospital

North Adelaide, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.