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New MRI scans could reveal hidden lung changes in cystic fibrosis patients

NCT ID NCT04391322

Ongoing Knowledge-focused Sponsor: The Hospital for Sick Children Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study uses advanced MRI scans to track lung structure and function in people with cystic fibrosis who are taking CFTR-modulator therapy. Researchers will compare MRI results with standard breathing tests and quality-of-life measures. The study includes healthy volunteers, stable CF patients, and children as young as 4 starting triple combination therapy. The goal is to see if MRI can detect treatment effects better than current methods.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this study could show that MRI is a better way to monitor lung health in cystic fibrosis patients on modulator therapy.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to immediate changes in care, and MRI results may not match standard breathing tests.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GROUP 1: HEALTHY CONTROLS GROUP 2: STABLE CF GROUP 3: CF PARTICIPANTS ANTICIPATED TO RECEIVE CFTR-MODULATOR THERAPY GROUP 4: 4-8 YO CF PARTICIPANTS STARTING TRIPLE COMBINATION MODULATOR THERAPY

Contacts and locations

Locations

  • The Hospital for Sick Children

    Toronto, Ontario, M5G 1X8, Canada

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