New study tracks Long-Term safety of leading CF drug in young children

NCT ID NCT06460506

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 25 times

Summary

This study looks at the long-term safety and how well the body handles a drug combination (elexacaftor/tezacaftor/ivacaftor, also known as Trikafta) in people with cystic fibrosis who are 12 months old or older. About 50 participants who completed a previous study will continue taking the medication. Researchers will monitor side effects and measure sweat chloride levels to see how well the treatment is working.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Alder Hey Children's NHS Foundation Trust

    Liverpool, United Kingdom

  • British Columbia Children's Hospital

    Vancouver, Canada

  • Charité Universitätsmedizin BerlinX

    Berlin, Germany

  • Children and Young Adults Research Unit

    Cardiff, United Kingdom

  • Erasmus Medical Center

    Rotterdam, Netherlands

  • Great Ormond Street Hospital for Children

    London, United Kingdom

  • Inselspital - Universitaetsspital Bern

    Bern, Switzerland

  • Juliane Marie Center, Rigshospitalet

    Copenhagen, Denmark

  • Kinderklinik III, Abt. fur Pneumologie

    Essen, Germany

  • Kinderspital Zurich

    Zurich, Switzerland

  • Leeds General Infirmary

    Leeds, United Kingdom

  • Medizinische Hochschule Hannover

    Hanover, Germany

  • Queensland Children's Hospital

    South Brisbane, Australia

  • Royal Brompton Hospital

    London, United Kingdom

  • Southampton General Hospital

    Southampton, United Kingdom

  • The Hospital for Sick Children

    Toronto, Canada

  • The Kids Research Institute Australia

    Nedlands, Australia

  • The Royal Children's Hospital

    Parkville, Australia

Conditions

Explore the condition pages connected to this study.