New triple therapy aims to control cystic fibrosis Long-Term

NCT ID NCT05844449

ENROLLING_BY_INVITATION Disease control Sponsor: Vertex Pharmaceuticals Incorporated Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 study tests the long-term safety and effectiveness of a triple combination drug (vanzacaftor/tezacaftor/deutivacaftor) in 174 people with cystic fibrosis aged 1 and older. Participants who completed a prior study will receive the drug to see if it helps control symptoms and improve lung function over time.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Vanzacaftor/tezacaftor/deutivacaftor (triple combination therapy)
What this could lead to: If successful, this could provide a long-term treatment option to help control cystic fibrosis symptoms and improve lung function.
What could go wrong: This is an open-label extension study, so results may be less reliable than blinded trials. Side effects or lack of sustained benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS

Contacts and locations

Show contact details

Locations

American Family Childrens Hospital

Madison, Wisconsin, 53792, United States
Ann & Robert H. Lurie Children's Hospital of Chicago - Hematology

Chicago, Illinois, 60611, United States
Boston Children's Hospital

Boston, Massachusetts, 02115, United States
British Columbia Children's Hospital

Vancouver, Canada
Charite Paediatric Pulmonology Department

Berlin, Germany
Children's Health Care d/b/a Children's Hospitals and Clinics of Minnesota

Minneapolis, Minnesota, 55404, United States
Children's Health Queensland Hospital and Health Service

South Brisbane, Australia
Children's Hospital of Colorado - Pulmonology

Aurora, Colorado, 80045, United States
Children's Hospital of Orange County

Orange, California, 92868, United States
Children's Hospital of Pittsburgh - Pulmonology

Pittsburgh, Pennsylvania, 15224, United States
Cincinnati Children's Hospital Medical Center - Pulmonology

Cincinnati, Ohio, 45229, United States
Cohen Children's Medical Center - Lakeville Road

Lake Success, New York, 11042, United States
Great Ormond Street Hospital for Children

London, United Kingdom
Hopital Femme Mere-Enfant

Bron, France
Hopital Necker Enfants Malades - Pulmonology

Paris, France
Hospital for Sick Children - Pulmonology

Toronto, Canada
Inselspital Bern

Bern, Switzerland
JW Riley Hospital for Children - Pulmonology

Indianapolis, Indiana, 46202, United States
Karolinska University Hospital - Pulmonology

Stockholm, Sweden
Kinderspital Zurich - Abteilung Pneumologie

Zurich, Switzerland
Medizinische Hochschule Hannover - Clinic for Pediatric Pneumology, Allergology and Neonatology, CF-Centre

Hanover, Germany
Nationwide Children's Hospital

Columbus, Ohio, 43205, United States
Noah's Ark Children's Hospital for Wales

Cardiff, United Kingdom
Sahlgrenska Universitetssjukhuset - Göteborg CF-center

Gothenburg, Sweden
Sophia Children's Hospital

Rotterdam, Netherlands
St. Louis Children's Hospital - Pulmonology

St Louis, Missouri, 63110, United States
Stanford University - Palo Alto - Pulmonology

Palo Alto, California, 94304, United States
Starship Child Health

Grafton, New Zealand
Texas Children's Hospital - Wallace Tower - Pulmonology

Houston, Texas, 77030, United States
The Children's Mercy Hospital

Kansas City, Missouri, 64108, United States
The Emory Clinic - Clifton Road - Pulmonology

Atlanta, Georgia, 30322, United States
The Kids Research Institute Australia

Nedlands, Australia
The Royal Children's Hospital Melbourne

Parkville, Australia
UH Cleveland Medical Center - Pulmonology

Cleveland, Ohio, 44106, United States
Universitatsklinikum Essen

Essen, Germany
Vermont Lung Center

Colchester, Vermont, 05446, United States
Women's & Children's Hospital

North Adelaide, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.