New MRI technique could revolutionize cystic fibrosis care

NCT ID NCT04259970

Ongoing Disease control Sponsor: Children's Hospital Medical Center, Cincinnati Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a special MRI technique that uses inhaled gas to create detailed images of lung function in people with cystic fibrosis. Researchers want to see how a new triple-combination therapy changes lung ventilation over time. The study involves 64 participants and aims to find better ways to measure treatment success, especially in early-stage disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CFTR modulator (triple combination therapy) and inhaled hyperpolarized 129Xe contrast for MRI
What this could lead to: If successful, this could help doctors use MRI to detect early lung changes in cystic fibrosis, guiding better and more personalized treatments.
What could go wrong: This is a small, early-phase study focused on imaging, not on proving the therapy works. The results may not apply to all patients or lead to immediate new treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS

Contacts and locations

Locations

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229-3019, United States
The Hospital for Sick Kids

Toronto, Ontario, M5G 1X8, Canada
University of Virginia School of Medicine

Charlottesville, Virginia, 22908, United States
University of Wisconsin

Madison, Wisconsin, 53792, United States

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