New MRI technique could revolutionize cystic fibrosis care
NCT ID NCT04259970
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a special MRI technique that uses inhaled gas to create detailed images of lung function in people with cystic fibrosis. Researchers want to see how a new triple-combination therapy changes lung ventilation over time. The study involves 64 participants and aims to find better ways to measure treatment success, especially in early-stage disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
CFTR modulator (triple combination therapy) and inhaled hyperpolarized 129Xe contrast for MRI
What this could lead to
If successful, this could help doctors use MRI to detect early lung changes in cystic fibrosis, guiding better and more personalized treatments.
What could go wrong
This is a small, early-phase study focused on imaging, not on proving the therapy works. The results may not apply to all patients or lead to immediate new treatments.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, 45229-3019, United States
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The Hospital for Sick Kids
Toronto, Ontario, M5G 1X8, Canada
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University of Virginia School of Medicine
Charlottesville, Virginia, 22908, United States
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University of Wisconsin
Madison, Wisconsin, 53792, United States