CYSTIC FIBROSIS
Clinical trials for CYSTIC FIBROSIS explained in plain language.
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First human test of inhaled gene therapy for cystic fibrosis halted early
Disease control TerminatedThis early-stage study tested a single inhaled dose of an experimental gene therapy called BI 3720931 in adults with cystic fibrosis who cannot use standard CFTR modulator drugs. The goal was to see if the treatment was safe and if it could improve lung function. The trial was te…
Matched conditions: CYSTIC FIBROSIS
Phase: PHASE1, PHASE2 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Apr 01, 2026 14:41 UTC
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Experimental pill tested to fight lung infections in cystic fibrosis
Disease control TerminatedThis study tested whether an experimental oral drug called roscovitine is safe for adults with cystic fibrosis who have a common genetic mutation and a chronic lung infection. Researchers gave different doses to 24 participants over 28 days, while 12 others received a placebo, to…
Matched conditions: CYSTIC FIBROSIS
Phase: PHASE2 • Sponsor: University Hospital, Brest • Aim: Disease control
Last updated Mar 30, 2026 14:33 UTC
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Common diabetes drug tested to help cystic fibrosis lungs
Disease control TerminatedThis study tested whether metformin, a common diabetes medication, could improve how cells in the airways work for adults with cystic fibrosis who also have diabetes. It was a small, terminated Phase 2 trial where participants took either a low or normal dose of metformin (or a p…
Matched conditions: CYSTIC FIBROSIS
Phase: PHASE2 • Sponsor: University of Kansas Medical Center • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Scientists test genetic patch to fix cystic fibrosis at its source
Disease control TerminatedThis study tested a new type of genetic therapy designed to fix a specific type of error in the CFTR gene that causes cystic fibrosis. Researchers used cells from 16 patients to see if custom-made 'oligonucleotide blockers' could repair the gene's instructions and restore normal …
Matched conditions: CYSTIC FIBROSIS
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Mar 04, 2026 15:30 UTC
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Doctors test 'Smart Stethoscope' to listen for lung disease clues
Diagnosis TerminatedThis study tested whether a special electronic stethoscope and artificial intelligence (AI) could help doctors better detect and measure abnormal lung sounds. It involved 23 adults with cystic fibrosis, pulmonary fibrosis, or COPD. The goal was to see if this technology could bec…
Matched conditions: CYSTIC FIBROSIS
Sponsor: Groupe Hospitalier de la Region de Mulhouse et Sud Alsace • Aim: Diagnosis
Last updated Mar 23, 2026 15:17 UTC
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Could a hormone help CF patients gain weight?
Symptom relief TerminatedThis small, early-stage study tested whether giving growth hormone could help adults with cystic fibrosis who were underweight. Researchers wanted to see if the hormone would help patients gain weight and muscle, improve their quality of life, and monitor its effects on diabetes …
Matched conditions: CYSTIC FIBROSIS
Phase: PHASE1 • Sponsor: University of Massachusetts, Worcester • Aim: Symptom relief
Last updated Mar 20, 2026 14:47 UTC
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Scientists gather clues to unlock cystic fibrosis mysteries
Knowledge-focused TerminatedThis study aimed to collect medical samples and information from people with cystic fibrosis (CF) during their regular doctor visits. The goal was to build a database for future research to better understand how the disease develops and varies between people. It did not test any …
Matched conditions: CYSTIC FIBROSIS
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Hidden lung threat in cystic fibrosis: nationwide hunt for silent bacteria
Knowledge-focused TerminatedThis study aimed to understand how common and serious infections from non-tuberculous mycobacteria (NTM) are in people with cystic fibrosis in France. Researchers observed 848 patients to measure how many had these bacteria in their lungs and tested a new blood test to detect pas…
Matched conditions: CYSTIC FIBROSIS
Sponsor: University Hospital, Brest • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:39 UTC