Breathable gas MRI could revolutionize CF lung monitoring
NCT ID NCT06339593
First seen Jan 17, 2026 · Last updated Jun 19, 2026 · Updated 21 times
Summary
This study looks at new ways to measure lung changes in people with cystic fibrosis (CF) aged 12 to 21. Researchers will use a special MRI with a breathable gas called Xenon, along with a lung function test called LCI, to see how stopping or restarting airway clearance treatment affects the lungs. The goal is to find better, more sensitive tools to monitor CF lung disease.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Cincinnati Children's Hospital
RECRUITINGCincinnati, Ohio, 45229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Hyperpolarized Xe129 gas (inhaled contrast agent for MRI)
What this could lead to
If successful, this could improve how doctors monitor lung health in cystic fibrosis, making it easier to detect early changes without invasive tests.
What could go wrong
This is an early-phase study with only 60 participants, so results may not apply to everyone. The new MRI techniques are still investigational and not yet FDA-approved.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.