Could waiting on antibiotics be better for kids with CF?
NCT ID NCT06654752
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 34 times
Summary
This study looks at two ways to treat lung flare-ups in children with cystic fibrosis. One group starts antibiotics right away, while the other only takes them if symptoms don't improve. Researchers will track lung function over a year to see which approach works better. The goal is to find a simpler, more tailored treatment plan.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Ann & Robert H. Lurie Children's Hospital of Chicago & Northwestern University
NOT_YET_RECRUITINGChicago, Illinois, 60611, United States
Contact Email: •••••@•••••
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Boston Children's Hospital & Harvard University
RECRUITINGBoston, Massachusetts, 02115, United States
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Contact Email: •••••@•••••
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British Columbia Children's Hospital
RECRUITINGVancouver, British Columbia, V6H 3V4, Canada
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Contact Email: •••••@•••••
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Children's Healthcare of Atlanta & Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
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Contact Email: •••••@•••••
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Children's Hospital of Colorado
RECRUITINGAurora, Colorado, 80045, United States
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Contact Email: •••••@•••••
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Children's Hospital of Los Angeles & Anton Yelchin Cystic Fibrosis Clinic
RECRUITINGLos Angeles, California, 90027, United States
Contact Email: •••••@•••••
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Children's Hospital of Philadelphia & University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Children's Hospital of Pittsburgh of UPMC & University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15224, United States
Contact Email: •••••@•••••
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Children's Hospitals and Clinics of Minnesota
RECRUITINGMinneapolis, Minnesota, 55404, United States
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Contact Email: •••••@•••••
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Children's Mercy Hospital
RECRUITINGKansas City, Missouri, 64108, United States
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Contact Email: •••••@•••••
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Children's Wisconsin & Medical College of Wisconsin
RECRUITINGMilwaukee, Wisconsin, 53226, United States
Contact Email: •••••@•••••
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
Contact
Contact Email: •••••@•••••
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Johns Hopkins Hospital, Johns Hopkins University
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Email: •••••@•••••
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
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Oregon Health & Science University
RECRUITINGPortland, Oregon, 97239-3098, United States
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Contact Email: •••••@•••••
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Rady Children's Hospital at University of California San Diego
NOT_YET_RECRUITINGSan Diego, California, 92123, United States
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Contact Email: •••••@•••••
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Riley Hospital for Children & Indiana University
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Seattle Children's Hospital
RECRUITINGSeattle, Washington, 98105, United States
Contact
Contact Email: •••••@•••••
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St. Louis Children's Hospital & Washington University School of Medicine
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Email: •••••@•••••
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Stanford University
RECRUITINGPalo Alto, California, 94304, United States
Contact
Contact Email: •••••@•••••
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Texas Children's Hospital & Baylor College of Medicine
RECRUITINGHouston, Texas, 77030, United States
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Contact Email: •••••@•••••
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The Children's Hospital Alabama & University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35233, United States
Contact Email: •••••@•••••
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The Hospital for Sick Children & Toronto Canada CF Centre Pediatrics
RECRUITINGToronto, Ontario, M5G 0A4, Canada
Contact Email: •••••@•••••
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The Minnesota Cystic Fibrosis Center & University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
Contact Email: •••••@•••••
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Tucson Cystic Fibrosis Center
RECRUITINGTucson, Arizona, 85713, United States
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Contact Email: •••••@•••••
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
Contact
Contact Email: •••••@•••••
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University of Michigan Health System
RECRUITINGAnn Arbor, Michigan, 48109-5212, United States
Contact Email: •••••@•••••
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27514, United States
Contact Email: •••••@•••••
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University of Rochester Medical Center Strong Memorial
RECRUITINGRochester, New York, 14642, United States
Contact Email: •••••@•••••
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University of Texas Southwestern & Children's Health
RECRUITINGDallas, Texas, 75235, United States
Contact Email: •••••@•••••
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University of Wisconsin
RECRUITINGMadison, Wisconsin, 53792, United States
Contact
Contact Email: •••••@•••••
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Vermont Children's Hospital & University of Vermont Medical Center
RECRUITINGBurlington, Vermont, 05401, United States
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Contact Email: •••••@•••••
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Virginia Commonwealth University
RECRUITINGRichmond, Virginia, 23298, United States
Contact Email: •••••@•••••
Contact
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
oral antibiotics
What this could lead to
If successful, this could show that starting antibiotics only when symptoms worsen is as safe and effective as immediate treatment, potentially reducing unnecessary antibiotic use.
What could go wrong
This is an open-label study, so results may be biased. The findings may not apply to all children with CF, and the tailored approach might lead to worse lung function in some cases.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.