Could waiting on antibiotics be better for kids with CF?

NCT ID NCT06654752

Recruiting now Disease control Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 04, 2026 · Updated 4 times

Summary

This study looks at two ways to treat lung flare-ups in children with cystic fibrosis. One group starts antibiotics right away, while the other only takes them if symptoms don't improve. Researchers will track lung function over a year to see which approach works better. The goal is to find a simpler, more tailored treatment plan.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: oral antibiotics
What this could lead to: If successful, this could show that starting antibiotics only when symptoms worsen is as safe and effective as immediate treatment, potentially reducing unnecessary antibiotic use.
What could go wrong: This is an open-label study, so results may be biased. The findings may not apply to all children with CF, and the tailored approach might lead to worse lung function in some cases.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CYSTIC FIBROSIS

Contacts and locations

Locations

Ann & Robert H. Lurie Children's Hospital of Chicago & Northwestern University
RECRUITING

Chicago, Illinois, 60611, United States
Boston Children's Hospital & Harvard University
RECRUITING

Boston, Massachusetts, 02115, United States
British Columbia Children's Hospital
RECRUITING

Vancouver, British Columbia, V6H 3V4, Canada
Children's Healthcare of Atlanta & Emory University
RECRUITING

Atlanta, Georgia, 30322, United States
Children's Hospital of Colorado
RECRUITING

Aurora, Colorado, 80045, United States
Children's Hospital of Los Angeles & Anton Yelchin Cystic Fibrosis Clinic
RECRUITING

Los Angeles, California, 90027, United States
Children's Hospital of Philadelphia & University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Pittsburgh of UPMC & University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15224, United States
Children's Hospitals and Clinics of Minnesota
RECRUITING

Minneapolis, Minnesota, 55404, United States
Children's Mercy Hospital
RECRUITING

Kansas City, Missouri, 64108, United States
Children's Wisconsin & Medical College of Wisconsin
RECRUITING

Milwaukee, Wisconsin, 53226, United States
Cincinnati Children's Hospital Medical Center
RECRUITING

Cincinnati, Ohio, 45229, United States
Johns Hopkins Hospital, Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21287, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239-3098, United States
Rady Children's Hospital at University of California San Diego
NOT_YET_RECRUITING

San Diego, California, 92123, United States
Riley Hospital for Children & Indiana University
RECRUITING

Indianapolis, Indiana, 46202, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
St. Louis Children's Hospital & Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63110, United States
Stanford University
RECRUITING

Palo Alto, California, 94304, United States
Texas Children's Hospital & Baylor College of Medicine
RECRUITING

Houston, Texas, 77030, United States
The Children's Hospital Alabama & University of Alabama at Birmingham
RECRUITING

Birmingham, Alabama, 35233, United States
The Hospital for Sick Children & Toronto Canada CF Centre Pediatrics
RECRUITING

Toronto, Ontario, M5G 0A4, Canada
The Minnesota Cystic Fibrosis Center & University of Minnesota
RECRUITING

Minneapolis, Minnesota, 55455, United States
Tucson Cystic Fibrosis Center
RECRUITING

Tucson, Arizona, 85713, United States
University of Iowa
RECRUITING

Iowa City, Iowa, 52242, United States
University of Michigan Health System
RECRUITING

Ann Arbor, Michigan, 48109-5212, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27514, United States
University of Rochester Medical Center Strong Memorial
RECRUITING

Rochester, New York, 14642, United States
University of Texas Southwestern & Children's Health
RECRUITING

Dallas, Texas, 75235, United States
University of Wisconsin
RECRUITING

Madison, Wisconsin, 53792, United States
Vermont Children's Hospital & University of Vermont Medical Center
RECRUITING

Burlington, Vermont, 05401, United States
Virginia Commonwealth University
RECRUITING

Richmond, Virginia, 23298, United States

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