New mRNA drug hopes to help cystic fibrosis patients who Can't use current therapies

NCT ID NCT06747858

Recruiting now Disease control Sponsor: Arcturus Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests an experimental mRNA medicine called ARCT-032 in 33 adults with cystic fibrosis who cannot take or do not benefit from current CFTR modulators. The goal is to see if the drug is safe and can improve lung function and quality of life. Participants will receive multiple doses, and researchers will monitor side effects and measure changes in breathing tests.

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Conditions

The condition(s) this trial relates to.

cystic fibrosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CFTR GENE MUTATION CYSTIC FIBROSIS

Contacts and locations

Locations

Boston Children's Hospital
RECRUITING

Boston, Massachusetts, 02115, United States
Children's Hospital of Los Angeles
RECRUITING

Los Angeles, California, 90027, United States
Children's National Hospital
NOT_YET_RECRUITING

Washington D.C., District of Columbia, 20010, United States
Cleveland Clinic Foundation
RECRUITING

Cleveland, Ohio, 44195, United States
Joe DiMaggio Children's Hospital
RECRUITING

Hollywood, Florida, 33021, United States
Medical University of South Carolina
RECRUITING

Charleston, South Carolina, 29425, United States
Seattle Children's Hospital
RECRUITING

Seattle, Washington, 98105, United States
The Cystic Fibrosis Institute
ACTIVE_NOT_RECRUITING

Northfield, Illinois, 60093, United States
UT Health San Antonio
RECRUITING

San Antonio, Texas, 78229, United States
University of Arizona
RECRUITING

Tucson, Arizona, 85724, United States
University of Arkansas for Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
Vanderbilt University Medical Center
RECRUITING

Nashville, Tennessee, 37232, United States
Washington University School of Medicine
RECRUITING

St Louis, Missouri, 63144, United States

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