Vision disorder

This study tests whether cenobamate, an experimental anti-epileptic drug, can safely reduce primary generalized tonic-clonic (PGTC) seizures when added to a person's usual seizure medications. Adults and adolescents aged 12 and older with PGTC seizures are randomly assigned to re…

This trial investigates whether bosentan, a drug that blocks endothelin and relaxes blood vessels, can help people who suddenly lose vision from giant cell arteritis (Horton's disease). Standard steroid treatment often fails to restore sight once blindness occurs. The study enrol…

This study tests a smart computer simulation (digital twin) of Saudi streets to train visually impaired people on safe navigation. Participants use 3D audio and a vibrating vest to learn to avoid obstacles. The goal is to see if this high-tech training reduces real-world collisio…

This completed trial tested whether virtual reality training could help children aged 4–7 with mild to moderate amblyopia (lazy eye) see better. 90 children were split into two groups: one used VR vision training software, and the other wore an eye patch for 2 hours daily. Resear…

This study tested a drug called cenobamate in 519 adults with partial onset seizures (focal seizures). Participants took cenobamate or a placebo alongside their usual seizure medications. The goal was to see if cenobamate could safely reduce seizure frequency. Results showed a si…

This Phase 3 trial tested a drug called XEN1101 (azetukalner) in 380 adults with focal-onset seizures that were not well-controlled by other medications. Participants took either XEN1101 or a placebo alongside their usual seizure drugs. The study measured whether XEN1101 reduced …

This study tested an eye injection called tarcocimab in 255 people with diabetic retinopathy, a diabetes complication that can damage vision. Participants received either the drug or a sham (fake) injection. The goal was to see if the drug improves the severity of the disease and…

This early-phase trial tested the drug rituximab in 3 people with ocular cicatricial pemphigoid, a rare autoimmune disease that causes scarring in the eye and can lead to blindness. The goal was to see if the drug could stop further scarring when standard treatments had failed. T…

This study tested the safety and effectiveness of brolucizumab, a drug injected into the eye, for treating diabetic macular edema (DME) in 66 Indian patients. DME is a complication of diabetes that can cause vision loss. The study aimed to see how well the drug works in real-worl…

This phase 3 trial tested a small, refillable implant placed in the eye that continuously releases the drug ranibizumab to control diabetic retinopathy. The study enrolled 174 people with moderate-to-severe non-proliferative diabetic retinopathy but without swelling in the center…

This study looked at whether giving exosomes through the nose could help improve vision in 32 children with cortical visual impairment (CVI), a vision problem caused by brain injury. The children received the treatment once a month for six months and were monitored for changes in…

This early-phase trial tested a combination of two drugs—fluvastatin (a cholesterol-lowering statin) and celecoxib (an arthritis drug)—in 20 children and young adults with certain brain tumors (gliomas) that had come back or not responded to treatment. The goal was to find the sa…

This early-phase study tested a new drug called CUDC-907 in 26 children and young adults (ages 1-21) with cancers that had come back or stopped responding to treatment, including solid tumors, brain tumors, and lymphoma. The main goal was to find a safe dose and check for side ef…

This study tested an investigational drug called RAP-219 in 30 adults with refractory focal epilepsy—seizures that don't respond well to current treatments. Participants took RAP-219 tablets to see if it safely reduces seizure frequency. The trial is now complete, and results wil…

This study tested the drug levetiracetam as the first treatment for seizures in 18 full-term newborns who had brain injury from lack of oxygen at birth. The goal was to find the right dose and check if it is safe and effective at reducing seizure activity on brain recordings. The…

This study looked at 200 women with eclampsia (a serious condition causing seizures during pregnancy) to see if giving magnesium sulphate into a vein (IV) or into a muscle (IM) works better to stop seizures from coming back. Women were randomly assigned to one of two treatment gr…

This study tested whether a single dose of naloxone, given right after a generalized tonic-clonic seizure, can help people with epilepsy breathe better and avoid sudden death. Researchers enrolled 485 adults with drug-resistant epilepsy who were already in the hospital for monito…

This study compared two different dosing schedules of brolucizumab (Beovu) in 52 people with wet age-related macular degeneration (AMD) who had not responded well to previous treatment. Participants received the drug as an eye injection either on a fixed schedule or with adjustme…

This study tested toric intraocular lenses (IOLs) in 236 children aged 3 to 8 who had cataracts and at least 2.0 diopters of astigmatism. All children had cataract surgery and received the special lens implant. Researchers tracked their vision and eye health for three years to se…

This study tested whether a special type of MRI that measures sodium levels in the brain can help locate the exact area causing seizures in people with drug-resistant epilepsy. 78 patients who were already scheduled for epilepsy surgery received a sodium MRI scan. Researchers com…

This study tested whether a nurse-assisted online eye screening app (Easee) is cost-effective for older adults receiving home healthcare. 234 participants aged 65+ used the app with a nurse's help to check their vision. The goal was to see if this approach reduces eye complaints …

This study tested a smartphone app that guides children through deep breathing (hyperventilation) and records their face and sounds to detect absence seizures. 65 children with and without seizure history participated. The app's accuracy was compared to standard EEG monitoring. T…

This study tested whether a simple eye-tracking system can identify children with childhood absence epilepsy and related thinking problems. Researchers compared eye movement recordings from 60 participants (kids with epilepsy and healthy controls) to standard tests. The goal is t…

This study tested whether giving the seizure drug levetiracetam right away can prevent seizures in people who had a brain bleed (hemorrhagic stroke). About 50 adults with a recent brain bleed received either the drug or a placebo. The goal was to see if the drug could reduce seiz…

This study tests a 10-week visual rehabilitation program for children with autism spectrum disorder who also have vision problems. The program uses games and activities to improve how children use their eyes and process visual information. Researchers want to see if better vision…

This study tested a specially designed video game to help children with amblyopia (lazy eye) follow their eye-patch therapy more consistently. 34 children participated, and the game aimed to make rehabilitation exercises more enjoyable and easier to stick with. The goal was to se…

This small proof-of-concept study tested a non-invasive device that uses sound and light to help people with hemianopia (blindness in half of the visual field). Five adults with stable hemianopia underwent training sessions where they were exposed to matching sound and visual cue…

This study looked at whether adding Epidiolex (a CBD-based medicine) to usual treatment can improve seizures, behavior, sleep, and quality of life in people aged 1 to 65 with tuberous sclerosis complex (TSC). 79 participants took the drug and were monitored for changes in symptom…

This study looked at using a heat-based technique called thermocoagulation in 100 children aged 1.5 to 17 years with focal epilepsy that doesn't respond to medication. During a brain monitoring procedure, doctors applied small heat lesions to the area where seizures start, aiming…

This pilot study tested a device called NaviFUS that uses focused ultrasound to stimulate the brain in 12 adults with drug-resistant epilepsy. The goal was to see if it is safe and can reduce seizure frequency. Participants kept seizure diaries and reported any side effects over …

This study tested a device that sends a very mild electrical current to the brain (tDCS) to see if it can safely reduce seizures in people with epilepsy that doesn't respond to medication. 127 participants aged 9 and older received either real or fake (sham) stimulation for 10 se…

This study tested an eye drop (POS) in 200 adults who had poor night vision after LASIK or similar eye surgery. The goal was to see if the drops could help them see better in dim light, reducing problems like glare and halos. Participants used the drops for 15 days and had their …

This study tested a structured program to help children and teens with autism, developmental delays, or intellectual disabilities cooperate during eye exams. Twenty participants attended six training sessions that used practice in a mock clinic, rewards like snacks or toys, and o…

This study tested a personalized vision therapy program for 38 children aged 4-18 with amblyopia (lazy eye) that did not respond to standard treatments like patching. The therapy was tailored to each child's visual and cognitive skills, aiming to improve how the brain processes v…

This pilot study tested whether prolonged exposure teletherapy can help adults with psychogenic nonepileptic seizures (PNES) and PTSD. Forty-four participants received either the teletherapy or standard education about PNES. The goal was to see if the therapy reduces seizure freq…

This study tested whether virtual reality (VR) exposure therapy could reduce anxiety in people with epilepsy who worry about their seizures. Fourteen participants were split into two groups: one received VR therapy using 360-degree videos of social or public settings, and the oth…

This study tested whether Nyxol eye drops can help people who have trouble seeing in dim light, often after eye surgeries like LASIK or cataract surgery. 144 adults received either the eye drops or a placebo for 8 days. The main goal was to see if Nyxol could improve vision in lo…

This study tested whether a sing-along song can help visually impaired individuals aged 6 to 20 learn to brush their teeth better. Forty participants in Nepal were split into two groups: one received standard audio-tactile instruction, and the other heard a song with the same ins…

This study looked at how cannabidiol (CBD) interacts with tacrolimus, a drug used to prevent organ rejection in transplant patients. Researchers wanted to understand how to adjust doses for better health outcomes. The study involved 57 healthy adults and those with chronic kidney…

This study looks back at 20 years of medical records from 25 people who had a freezing treatment (cryotherapy) for retinal hemangioblastoma, a rare eye tumor often linked to von Hippel-Lindau disease. Researchers want to see how well the treatment controlled the tumors and affect…

This study looked at how nerve cells in the eye are lost in people with multiple sclerosis (MS) even when there is no active inflammation. Researchers followed 64 adults with relapsing-remitting MS who were already part of a larger study. By using special eye scans over time, the…

Infantile spasms are a type of seizure that can harm development if not treated quickly, but they are often mistaken for normal movements. This study tested a computer program that learns from parent-recorded videos to tell the difference between these seizures and harmless movem…

This completed study looked at whether healthcare professionals in Saudi Arabia received and understood safety materials about the epilepsy drug Depakine (sodium valproate). Researchers surveyed 455 doctors, pharmacists, and gynecologists to measure their knowledge and behavior. …

This early-phase study looked at how a single dose of cannabidiol (CBD) affects brain inflammation and pain sensitivity in 28 healthy adults. Researchers used brain scans to measure inflammation and a skin cream test to check pain response. The goal was to understand CBD's potent…

This study looked at how blood pressure and heart rate change in the hour after an epileptic seizure. Researchers measured these vital signs at several time points in 1,100 people with epilepsy. The goal was to better understand the body's response right after a seizure, which ma…

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This study tested a new portable, wireless EEG monitor called NeuroBell on 17 full-term newborns who already needed brain monitoring. The goal was to see if the new device records brain signals as well as standard EEG machines. The study did not treat any condition, but aimed to …

This study tested a medicine called cenobamate in 26 children with partial-onset seizures. The goal was to see how the drug moves through the body and if it is safe. The study did not aim to cure or control seizures long-term, but to gather important information for future use.

This study tested whether an audio-based educational program about puberty could improve self-concept and healthy behaviors in visually impaired teenage girls. Forty-six girls aged 12-18 from two schools in Egypt took part. The program used simple Arabic audio sessions and Braill…

This study looked at how well people can sense and copy the speed of their knee movement, with and without vision. Sixty healthy adults tried to match two different speeds (slow and fast) while either keeping their eyes open or closed. The goal was to understand how vision contri…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study looked for early signs of epilepsy in children with autism and tested whether a structured exercise program could influence those signs. Fifty children aged 10-15 with autism, epilepsy, or both took part. Researchers analyzed blood, sleep, brain activity, and thinking …

This completed study looked at 72 newborns who had seizures shortly after birth. Researchers measured inflammation markers in their blood and tracked whether they later developed epilepsy. The goal was to understand if inflammation plays a role in epilepsy risk after neonatal sei…

This study aims to create an algorithm that detects epileptic seizures by continuously analyzing the heart's electrical activity (ECG). Researchers will use data from 40 epilepsy patients who had seizures recorded during long-term video-EEG monitoring. The goal is to see how accu…

This completed study looked at whether the sedative ketamine can cause seizure-like brain activity in people without epilepsy. Researchers monitored 300 adults undergoing a routine stomach scope procedure using EEG brain scans. They compared ketamine to two other common sedatives…

This study tested a new questionnaire designed to measure how well babies (0-36 months old) with eye diseases can see, even before they can talk. The goal was to help doctors decide the best time for surgery. The study included 150 children with different eye conditions and check…

This study looked at whether thinning of the retina (the back part of the eye) can be a sign of Alzheimer's disease. Researchers compared eye scans from 55 people with Alzheimer's, Lewy body disease, and healthy volunteers. The goal was to see if measuring retinal layers could he…

This study looked at new ways to measure and train eye movements in 21 people with macular degeneration, a condition that causes central vision loss. The goal was to see if training could help them use their remaining side vision more effectively. The research focused on understa…

This completed study measured how the eye scatters light at different wavelengths and pupil sizes in 31 adults aged 18-75. Participants had their vision corrected with an adaptive optics system, and researchers recorded how a point of light blurred inside the eye. The goal was si…

This study tested if sending SMS reminders to parents helps children get follow-up eye care after a school vision screening. About 320 children aged 5-15 from two schools in Rawalpindi, Pakistan, were screened using a smartphone app. Those who needed further care were split into …

This study looked at 100 older adults (60+) to see if those with severe vision loss from age-related macular degeneration have more shoulder pain, stiffness, and movement problems compared to those with normal vision. Researchers measured pain, range of motion, and daily living a…

This study looked at how often people have vision problems after a stroke. Researchers followed 127 stroke patients for 3 months, testing their eyesight and comparing results with brain scans. The goal was to find out how common these issues are and whether a simple vision screen…