Vision disorder

This study tests an oral drug, AV078, in people aged 12 and older with tuberous sclerosis complex (TSC) whose seizures are not controlled by standard medications. Participants are randomly assigned to receive AV078 or a placebo for 12 weeks. The goal is to see if AV078 safely red…

This study tests whether a training program that pairs sounds with visual cues can help people who have lost part of their vision due to brain damage (cortical blindness). Participants will do 12 sessions where they see and hear stimuli in their blind area, plus virtual reality t…

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This trial tests a new device called the enVVe system, a catheter-based artificial valve placed in leg veins to treat chronic venous insufficiency. The study will enroll 220 people with severe symptoms like skin changes or leg ulcers. Participants are randomly assigned to receive…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests whether adding echothiophate iodide eye drops to standard atropine therapy can improve vision in children aged 3 to 18 with refractory amblyopia (lazy eye that hasn't improved with standard treatment). Twenty participants will use atropine nightly for 12 weeks, a…

This study tests whether adding specially designed digital games to standard eye-patch therapy can improve vision and motivation in children aged 4 to 7 with lazy eye (amblyopia). Sixty-six children will either wear an eye patch alone or combine it with a touchscreen or augmented…

This study looks at the best way to switch children with Dravet or Lennox-Gastaut syndrome from artisanal (non-pharmaceutical) cannabidiol to Epidiolex, an FDA-approved CBD medication. About 25 children aged 2 to 18 will gradually increase their Epidiolex dose while reducing thei…

This early-stage trial tests whether adding the drug valproate to standard patching therapy can improve vision in children aged 8 to 17 with lazy eye (amblyopia). Participants will take valproate or a placebo daily for 8 weeks while patching the stronger eye. The study aims to se…

This study tests whether a structured referral tracking program helps adults in Pakistan complete follow-up eye care after community screenings. 500 participants will receive either standard referral or extra support like counseling and weekly reminders. The goal is to prevent bl…

This study tests whether levetiracetam, a seizure medication, works as well as magnesium sulfate to prevent seizures in pregnant people with severe preeclampsia. About 1,240 participants at 32 weeks or more will be randomly assigned to one of the two drugs. The goal is to see if …

This study tests a non-invasive technique called temporal interference stimulation to boost deep sleep in people with epilepsy. Researchers will compare 4 nights of real stimulation to 4 nights of sham (fake) stimulation in up to 16 patients. The goal is to see if better sleep ca…

This study tests if a special augmented reality (AR) training program can improve vision in people aged 12 to 55 with lazy eye (amblyopia). It compares the AR method to the standard treatment of patching the stronger eye. The goal is to see if the AR approach is safer and more ef…

This study tests a new way to improve vision loss caused by a stroke. It combines low-intensity focused ultrasound (LIFUS) with virtual reality therapy to stimulate the brain's vision areas. The study will enroll 28 adults who had a stroke 6 to 24 months ago and now have partial …

This study tests whether watching 3D movies, combined with standard patching therapy, improves depth perception and vision in children aged 4 to 14 with amblyopia (lazy eye). Half the children will receive patching alone, while the other half will also attend weekly 3D movie sess…

This study tests whether a non-invasive brain stimulation technique called tDCS can safely improve vision in 100 children aged 4-14 with lazy eye (amblyopia) that hasn't improved with standard patching. Children will receive either real or sham tDCS over three sessions, and their…

This study tests a training technique that uses repeated flashes of light and bursts of sound to help people who have lost part of their vision after a stroke. The goal is to see if this training can improve how much they can see and how their brain responds. The study will inclu…

This study looks at whether adding osteopathic manual therapy (a type of hands-on body treatment) to standard vision therapy can help people with eye coordination problems that cause eyestrain, blurred vision, and headaches. The trial will involve 100 adults who work on screens a…

This study looks at whether special posture exercises or a wearable sensor can help improve mild vision problems in university students with forward head posture. 72 participants will be split into three groups to compare different training methods. The goal is to see if correcti…

This study explores how visual impairment affects movement and daily activities, and tests a wearable system called VIS4ION that provides audio and touch cues to help users navigate. Researchers will enroll 150 adults with visual impairment and healthy controls to see if the devi…

This clinical trial tests whether transcranial magnetic stimulation (TMS) can restore vision in adults with severe retinal degeneration. Over 100 participants will receive either real TMS or a sham (fake) treatment for five days, and their eyesight will be checked up to a year la…

This study tests whether meditation or a health education program can improve quality of life and mental health for people with irreversible age-related vision loss and their caregivers. About 150 participants will be assigned to either meditation training or health classes, both…

This study looks at whether taking a daily supplement of lutein, zeaxanthin, and meso-zeaxanthin (natural pigments found in plants) can improve contrast sensitivity—the ability to see subtle differences in light and dark—in healthy Chinese adults aged 35 and older. Over 12 months…

This study tests whether Meta AI glasses, connected to the Be My Eyes network, can help people with permanent vision loss walk and move around more easily. The glasses describe scenes and objects in real time. Fifty participants will use the glasses and report changes in their qu…

This study tests whether watching 3D movies can improve depth perception and vision in children aged 4 to 12 who still have some vision loss from lazy eye (amblyopia) despite prior treatment. Forty children will be randomly assigned to watch three movies in either 3D or 2D, then …

This study tests whether patching the stronger eye in the morning (8-10 AM) or evening (5-7 PM) works better for improving vision in children with lazy eye (amblyopia). About 100 children aged 4-8 will wear an eye patch for 2-6 hours daily over 6 months. The goal is to see if tim…

This study looks at whether a common procedure for varicose veins—called endovenous ablation—can also reduce knee pain in people aged 80 and older. The researchers will follow 50 participants for one year after treatment, measuring pain and knee function. The goal is to see if im…

This study will see if setting up vision centers in rural South Asian communities helps more people get the eye care they need. Researchers will compare communities that get a vision center right away with those that wait. They will check if more people get glasses and if their e…

This observational study aims to understand why individuals perceive colours and visual rivalry differently. Researchers will test 128 adults using computer-based tasks to measure colour perception and binocular rivalry (when each eye sees a different image). They will also explo…

This observational study will compare dental caries (tooth decay) experiences and quality of life between visually impaired and sighted children aged 6 to 14. Researchers will use a special questionnaire to measure how cavities affect daily life, and will also count decayed, miss…

This study will see if outdoor activities like rafting, canyoning, and kayaking can help teens with and without disabilities feel more included and connected. About 35 teens aged 12–16 will take part, with some doing the activities and others not. Researchers will measure changes…

This observational study will track 87 people who are already scheduled to receive treatment with the Recana Thrombectomy Catheter System for blocked veins in their legs. The goal is to see how safe the device is and how well it works at clearing the blockages during the procedur…

This study will test whether using virtual reality headsets raises the risk of seizures in adolescents and adults with epilepsy. Forty participants will wear a VR headset while their brain activity is recorded with EEG, comparing periods with the display off, on, and with hand co…

This study will look at what happens when a standalone eye center becomes part of a government hospital in Kalaiya, Nepal. Researchers will track changes in how many patients visit, follow up, and get referrals, and ask patients and staff what they think. The goal is to learn if …

This early-phase study tests whether the drug Cobenfy KarXT can change brain activity linked to memory in 50 adults with epilepsy who are already scheduled for brain surgery. Participants will take either the drug or a placebo on separate days and perform memory tasks while their…

This study at Stanford University will test how the brain responds when visual information is turned into patterns of sound or touch. Two hundred blind and sighted participants will use special devices (BrainPort and AI Sight) for 5 weeks. Researchers will use brain scans and per…

This study looks at children born prematurely who had retinopathy of prematurity (ROP), a disease that can cause blindness. Some were treated with laser, others with injections, and some had ROP but no treatment. Researchers will compare their vision and retina structure to see w…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study will follow 200 children with epilepsy to find clues—like brain scans or EEG patterns—that show which kids are likely to become resistant to standard seizure medications. The goal is to catch these cases early and consider alternative treatments such as a ketogenic die…

This study will track 139 newborns who have seizures in their first month of life to learn how common these seizures are, what causes them, and how the babies fare during their hospital stay. Researchers will use exams, blood tests, and brain scans to gather information. The goal…

This study looks at whether shifting text to a different part of the eye can help people with central vision loss read faster and more accurately. Researchers will test 100 participants with conditions like macular degeneration using various reading tasks. The goal is to find bet…

This study will follow 50 adults with varicose veins and chronic knee pain who are scheduled for standard vein treatment (laser or radiofrequency ablation). Researchers will measure changes in knee pain, stiffness, and function before and after the procedure. The goal is to see i…