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Temporomandibular joint dysfunction syndrome
MONDO:0021895A common disorder noted with jaw movement. It may be caused by malocclusion, repetitive use injury, trauma or arthritis. It is more prevalent among females between their second and fourth decades. Clinical signs include preauricular pain, temporomandibular joint clicking (as the mandibular condyle slips from the articulation made with the capsular disk and temporal bone) and restriction of jaw motion. Clinical course is typically benign but may progress to associated headaches, ear and neck pain, tinnitus and dislocation of temporomandibular joint. Prognosis is favorable as a majority of cases will respond to conservative management.
Also known as: temporomandibular joint dysfunction syndrome, Costen Syndrome, Costen's Syndrome, Costen's complex, Costen's syndrome, Costens Syndrome, Joint Syndrome, Temporomandibular, Mandibular dysfunction
114 clinical trials for this condition and its sub-types.
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New combo therapy for jaw pain shows promise in small trial
Disease control CompletedThis study tested a treatment for a common jaw joint problem called TMJ anterior displacement, where the joint disc slips out of place. The treatment involved flushing the joint (arthrocentesis), then injecting platelet-rich plasma (a concentrate of the patient's own healing cell…
Phase: PHASE3 • Sponsor: Suez Canal University • Aim: Disease control
Last updated Jun 27, 2026 11:03 UTC
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New digital splint aims to quiet clicking jaws in teens
Disease control CompletedThis study tested a custom-made digital splint to reposition the jaw in 48 adolescents with painful, clicking jaw joints due to disc displacement. Participants wore the splint 24/7 and had regular check-ups with imaging. The goal was to improve pain, chewing, and quality of life.…
Phase: NA • Sponsor: Fujian Medical University • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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Knee implant study shows good function after two years
Disease control CompletedThis study looked at how well a specific knee replacement (balanSys UNI) works over time. 116 people with knee arthritis got the implant and were followed for at least 2 years. Doctors measured knee function using the Knee Society Score and checked X-rays for any problems.
Sponsor: Mathys Ltd Bettlach • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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High-Tech surgery may keep jaw in place
Disease control CompletedThis study tested whether using computer-guided surgery is better than the standard approach for fixing a jaw that keeps dislocating. Seven adults with the condition took part. The main goal was to see if the jaw stayed in place after surgery, and the study also measured how wide…
Phase: NA • Sponsor: Beni-Suef University • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Could ozone gas ease your jaw pain? new study tests it
Symptom relief CompletedThis study tested two different strengths of ozone gas injections into the jaw joint for people with TMJ disorders. Twenty adults who had clicking, popping, or limited mouth opening that didn't improve with other treatments received the injections. Researchers measured pain and j…
Phase: NA • Sponsor: Alexandria University • Aim: Symptom relief
Last updated Jun 27, 2026 14:03 UTC
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Botox shots aim to ease chronic jaw pain in new study
Symptom relief CompletedThis study tested whether injecting botulinum toxin (Botox) into jaw muscles can reduce pain and improve mouth opening in people with temporomandibular joint (TMJ) myofascial pain. 118 adults with at least moderate pain for over a month received injections in their masseter and t…
Phase: PHASE4 • Sponsor: PAEC General Hospital, Islamabad • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Jaw pain relief? PRP and hyaluronic acid injections show promise in small study
Symptom relief CompletedThis study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …
Phase: NA • Sponsor: Mansoura University • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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New laser zaps TMJ pain in small trial
Symptom relief CompletedThis completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…
Phase: NA • Sponsor: BTL Industries Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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Jaw pain relief: simple exercises may reduce sensitivity and improve function
Symptom relief CompletedThis study looked at whether adding aerobic or strength exercises to standard physical therapy can better reduce pain and sensitivity in people with chronic jaw disorders. 51 adults with jaw pain and nociplastic pain (widespread sensitivity) participated. The goal was to see if t…
Phase: NA • Sponsor: Universitat Internacional de Catalunya • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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Stretching your way to better hips? pilot study tests the idea
Symptom relief CompletedThis pilot study looked at whether passive static stretching can increase hip flexibility in three groups: people who had hip replacement, those with long-term hip pain, and healthy volunteers. Twelve participants followed a 4-week stretching program three times a week under supe…
Sponsor: Omicron beta research • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Jaw pain breakthrough? three injections tested after TMJ procedure
Symptom relief CompletedThis study tested whether adding an injection of hyaluronic acid, platelet-rich fibrin, or dextrose to a standard jaw washout procedure (arthrocentesis) improves pain and jaw function more than the washout alone. Thirty-six adults with TMJ disorders who hadn't improved with other…
Phase: NA • Sponsor: Ondokuz Mayıs University • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Jaw pain showdown: physiotherapy vs. night splints
Symptom relief CompletedThis study tested two common treatments for jaw muscle pain (TMD) in 24 adults: a 6-week physiotherapy program with hands-on massage and exercises, versus wearing a mouth splint at night. The goal was to see which better reduces pain, improves mouth opening, and boosts quality of…
Phase: NA • Sponsor: Egas Moniz - Cooperativa de Ensino Superior, CRL • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Botox eases jaw pain in small trial
Symptom relief CompletedThis study looked at whether Botox injections can reduce pain and improve jaw movement in people with chronic jaw muscle pain that didn't get better with standard treatments. Twenty-five participants received Botox injections into their jaw muscles. Researchers measured pain leve…
Phase: NA • Sponsor: Hacettepe University • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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Simple jaw exercises may ease TMJ pain
Symptom relief CompletedThis study tested a set of jaw and neck exercises in 64 adults with craniomandibular dysfunction (jaw joint problems). The exercises included chin tucks, chest stretches, and gentle neck and jaw movements. Researchers measured pain levels and jaw function before and after four we…
Phase: NA • Sponsor: Riphah International University • Aim: Symptom relief
Last updated Jun 27, 2026 09:05 UTC
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New splint adjustment technique could ease jaw pain for millions
Symptom relief CompletedThis study tested a specific technique for adjusting occlusal stabilizing splints used to treat temporomandibular disorders (TMD), which cause jaw pain and dysfunction. Researchers enrolled 800 patients with TMD and assessed their satisfaction after using the adjusted splints. Th…
Phase: NA • Sponsor: Mansoura University • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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Botox or PRF: which injection eases jaw pain best?
Symptom relief CompletedThis study tested two injection treatments for temporomandibular joint (TMJ) problems that cause jaw pain and clicking. Twenty patients received either Botox into a jaw muscle or platelet-rich fibrin (a substance made from their own blood) into the joint space. Researchers measur…
Phase: NA • Sponsor: Suez Canal University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Jaw pain relief? new injection mix shows promise in small trial
Symptom relief CompletedThis completed study tested whether injecting a mix of platelet-rich fibrin and hyaluronic acid into the jaw joint could help people with TMJ disc problems. Thirty adults with jaw pain, clicking, and limited movement received the treatment or a standard injection. Researchers mea…
Phase: NA • Sponsor: Suez Canal University • Aim: Symptom relief
Last updated Jun 27, 2026 09:00 UTC
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Physiotherapy students test muscle relief techniques on themselves
Symptom relief CompletedThis study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Can simple posture exercises ease jaw pain? new study investigates
Symptom relief CompletedThis study looked at whether adding postural exercises to standard occlusal splint therapy can better reduce pain and improve jaw function in people with internal temporomandibular joint (TMJ) disorders. Fifty-seven adults were split into three groups: one received only a mouth s…
Phase: NA • Sponsor: Istanbul University • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Mind over jaw pain: new therapy shows promise for TMD sufferers
Symptom relief CompletedThis study tested whether adding pain neuroscience education, motor imagery, and action observation to standard treatment (splint, exercises, counseling) helps people with chronic temporomandibular disorders (TMD). Fifty adults with jaw pain for at least 3 months participated. Th…
Phase: NA • Sponsor: University of Gran Rosario • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Jaw pain relief: simple exercises may ease TMJ dysfunction
Symptom relief CompletedThis completed study tested whether adding breathing exercises or back exercises to standard jaw muscle therapy could improve pain, jaw function, spine mobility, and mood in people with temporomandibular joint (TMJ) dysfunction. 63 adults aged 18-65 with muscle-related TMJ issues…
Phase: NA • Sponsor: Merve Keskin • Aim: Symptom relief
Last updated Jun 27, 2026 08:10 UTC
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Jaw pain relief at home: study tests virtual therapy
Symptom relief CompletedThis study tested whether physical therapy for temporomandibular disorders (TMD) — which cause jaw pain, headaches, and clicking — works just as well when done virtually (via video calls) as in person. Over 200 adults with TMD were split into two groups: one received standard in-…
Sponsor: University of Minnesota • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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New splint design eases jaw pain for TMJ sufferers
Symptom relief CompletedThis study tested a new way to design a jaw splint for people with a common jaw joint problem (TMJ disc displacement). Instead of the usual method, doctors used a computer analysis called VTO to find the best splint position. 20 adults with confirmed TMJ disc displacement took pa…
Phase: NA • Sponsor: Fujian Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Ultrasound guidance may improve jaw injections for TMJ pain
Symptom relief CompletedThis study tested whether using ultrasound to guide hyaluronic acid injections into the jaw joint works better than the usual method for people with a displaced jaw disc. Forty adults who had not improved with other treatments received either ultrasound-guided or standard injecti…
Phase: NA • Sponsor: Muhannad • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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Who should control your sedation during surgery? new study compares options
Symptom relief CompletedThis study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…
Phase: NA • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Ancient meets modern: can acupuncture and herbs ease jaw pain?
Symptom relief CompletedThis study looked at whether adding Traditional Chinese Medicine (TCM) to a self-care program helps people with jaw pain (TMD). 135 adults with moderate to severe pain were given different levels of care based on how they responded. The goal was to see if TCM could improve pain a…
Phase: PHASE2 • Sponsor: University of Arizona • Aim: Symptom relief
Last updated Jun 27, 2026 07:55 UTC
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Robot-Assisted knee surgery may outperform traditional methods
Symptom relief CompletedThis study compared robotic-assisted total knee replacement to the conventional technique in 95 patients with knee arthritis. The goal was to see if robotic surgery leads to better knee function, less pain, and higher satisfaction two years after the operation. Researchers also c…
Phase: NA • Sponsor: Hospital de Terrassa • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Hands-On therapy eases jaw pain for rheumatoid arthritis patients
Symptom relief CompletedThis study tested two types of manual therapy (myofascial mobilization and joint mobilization) in 57 people with rheumatoid arthritis who also had jaw joint problems. Participants received therapy twice a week for six weeks, while a control group got no treatment. Both therapy gr…
Phase: NA • Sponsor: Sanko University • Aim: Symptom relief
Last updated Jun 26, 2026 16:49 UTC
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Jaw pain headaches? Hands-On therapy and Brain-Body exercises show promise
Symptom relief CompletedThis study looked at whether manual therapy (hands-on treatment) and a cognitive exercise therapy approach (BETY) can reduce headache pain and improve quality of life in people with temporomandibular disorder (TMD)-related headaches. 60 adults with TMD headaches were split into g…
Phase: NA • Sponsor: Hasan Kalyoncu University • Aim: Symptom relief
Last updated Jun 26, 2026 12:59 UTC
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New turkish health survey could improve care for muscle and joint problems
Knowledge-focused CompletedThis study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…
Sponsor: Istanbul Bilgi University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Teen jaw pain linked to headaches and back pain, new study finds
Knowledge-focused CompletedThis completed study surveyed 566 adolescents aged 14 to 16 to understand how jaw pain (temporomandibular disorders) relates to other painful conditions like headaches, neck pain, and back pain. Researchers used anonymous questionnaires to identify common co-occurring health issu…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New study reveals hidden factors behind chronic neck pain
Knowledge-focused CompletedThis study looked at 84 adults with chronic neck pain to see how central sensitization (a condition where the nervous system becomes overly sensitive) relates to pain intensity, thinking patterns, sleep quality, and jaw function. Researchers used questionnaires to measure these f…
Sponsor: Turkoglu Dr. Kemal Beyazit State Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Physios take on ER duty: study tests if they can replace doctors for back pain
Knowledge-focused CompletedThis study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…
Phase: NA • Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Childhood trauma linked to worse jaw function in new study
Knowledge-focused CompletedThis study looked at how traumatic experiences—both in childhood and later in life—impact jaw function and quality of life in people with temporomandibular joint disorder (TMD). Researchers compared 102 adults with TMD to healthy volunteers using questionnaires about trauma, jaw …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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MRI reveals hidden jaw disc tears in 282 patients
Knowledge-focused CompletedThis study looked at whether MRI scans can reliably find a torn disc in the jaw joint (temporomandibular joint). Researchers reviewed MRI images and medical records from 282 people to see how often disc tears occur and how they relate to pain, disc shape, and bone changes. The go…
Sponsor: Recep Tayyip Erdogan University Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Can CRPS patients imagine movement? new study investigates
Knowledge-focused CompletedThis completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC