Temporomandibular joint dysfunction syndrome
MONDO:0021895A common disorder noted with jaw movement. It may be caused by malocclusion, repetitive use injury, trauma or arthritis. It is more prevalent among females between their second and fourth decades. Clinical signs include preauricular pain, temporomandibular joint clicking (as the mandibular condyle slips from the articulation made with the capsular disk and temporal bone) and restriction of jaw motion. Clinical course is typically benign but may progress to associated headaches, ear and neck pain, tinnitus and dislocation of temporomandibular joint. Prognosis is favorable as a majority of cases will respond to conservative management.
Also known as: temporomandibular joint dysfunction syndrome, Costen Syndrome, Costen's Syndrome, Costen's complex, Costen's syndrome, Costens Syndrome, Joint Syndrome, Temporomandibular, Mandibular dysfunction
114 clinical trials for this condition and its sub-types.
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Could a common drug ease painful jaw clicking?
Disease control OngoingThis study tests whether adding the drug sodium valproate to a standard jaw-washing procedure can lower inflammation in people with a painful jaw joint condition. Ten female participants with jaw clicking and pain will receive the drug intravenously during the procedure. Research…
Phase: PHASE2 • Sponsor: Tanta University • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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New combo treatment aims to quiet jaw pain for TMD sufferers
Symptom relief OngoingThis study tests whether wearing a custom mouth splint and getting a granisetron injection into the jaw muscle reduces pain from temporomandibular disorders (TMD) better than the splint alone or with lidocaine. About 48 adults with jaw muscle pain will be followed for 6 months. T…
Phase: PHASE4 • Sponsor: Mansoura University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Precision needle aims to ease jaw pain in new trial
Symptom relief OngoingThis study tests a computer-guided needle technique combined with a platelet-rich plasma (PRP) injection for people with a painful jaw joint condition called temporomandibular disorder (TMD). The goal is to see if the computer-guided method improves jaw function and reduces pain …
Phase: NA • Sponsor: Alexandria University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Weekly Check-Ins could boost patient satisfaction for chronic pain
Knowledge-focused TerminatedThis study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…
Phase: NA • Sponsor: University of Texas at Austin • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Can a special clinic get workers back on the job faster? norway launches massive study.
Knowledge-focused OngoingThis study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…
Phase: NA • Sponsor: Nordlandssykehuset HF • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Hip implant under the microscope: 5-Year safety study launched
Knowledge-focused OngoingThis study is tracking 120 people who received a HYPE SCS hip stem during total hip replacement. Researchers will monitor how long the implant lasts, how satisfied patients are, and any complications over 5 years. The goal is to confirm the device is safe and works as intended in…
Sponsor: Societe dEtude, de Recherche et de Fabrication • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Can exosomes heal jaw pain? new lab study investigates
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at tiny particles called exosomes, taken from a patient's own platelet-rich plasma, to see if they might help repair jaw joints. Researchers will compare these exosomes with other blood products in lab tests on cells. The goal is to understand their content and p…
Sponsor: Wroclaw Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Grinding your teeth? it might be connected to pelvic pain and erectile dysfunction
Knowledge-focused ENROLLING_BY_INVITATIONThis study is investigating whether bruxism (teeth grinding or clenching) is associated with pelvic pain, erectile dysfunction, and anxiety in young men aged 18-30. Researchers will use questionnaires and physical exams to assess 100 participants. The goal is to better understand…
Sponsor: Akdeniz University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Could your jaw pain be connected to pelvic floor issues? new study investigates
Knowledge-focused ENROLLING_BY_INVITATIONThis study explores whether bruxism (teeth grinding or clenching) is related to pelvic floor dysfunction in young women aged 18-30. Researchers will use questionnaires and physical exams to assess jaw function, pelvic floor symptoms, and anxiety in 100 participants. The goal is t…
Sponsor: Akdeniz University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Massive PT study mines 4 million records to find what works best
Knowledge-focused OngoingThis study looks back at the medical records of about 4 million people who had physical or occupational therapy for muscle and joint problems. Researchers want to see if different ways of giving therapy lead to different results. No new treatments are tested—the goal is to learn …
Sponsor: ATI Holdings, LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Phone app vs. doctor: can a mobile tool catch infections after surgery?
Knowledge-focused TerminatedThis study aimed to see if a mobile monitoring tool could accurately identify surgical site infections (SSIs) in orthopedic surgery patients, compared to the usual manual review. The study was withdrawn before enrolling any participants, so no results are available. It was design…
Phase: NA • Sponsor: Stanford University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC