Systemic lupus erythematosus

This study looked at whether the HPV vaccine works in girls aged 9 to 17 who are taking medicines that weaken their immune system, such as after an organ transplant or for diseases like lupus. The goal was to see if their bodies produce enough antibodies to protect against HPV. T…

This study tested an extra dose of the HIPRA COVID-19 vaccine in 241 adults with conditions like HIV, kidney disease, or autoimmune disorders that weaken the immune system. The goal was to see if the booster raises antibody levels against virus variants and remains safe. Research…

This early-phase study tested the safety of a new drug, CUG252, in 40 adults with mild-to-moderate systemic lupus erythematosus (SLE). Participants received multiple doses of the drug or a placebo by injection. The main goal was to see if the drug is safe and tolerable, and to un…

This early-stage trial tested a drug called itolizumab (EQ001) in 52 adults with lupus, some of whom also had active kidney inflammation. The main goal was to check safety and find the right dose. Researchers also looked at how the drug behaves in the body and how it affects immu…

This study looked at 152 adults with systemic lupus erythematosus (SLE) who started taking anifrolumab during its first year on the market in Spain. Researchers tracked their disease activity, flare-ups, and remission rates using standard medical records. The goal was to see how …

This early-phase trial tested an experimental drug called DS-7011a in 26 adults with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The study aimed to check the drug's safety and how the body processes it, not yet to prove it works. Participants received either…

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This early-phase study tested a new drug called BMS-986326 in 45 adults with different forms of lupus, including skin and systemic lupus. The main goal was to check safety and how the body processes the drug, not yet to see if it works. Participants received either the drug or a …

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This study tested a drug called anifrolumab in 277 Asian adults with active lupus. The goal was to see if it could better control the disease compared to a placebo, when added to standard treatments. Participants received the drug or placebo through an IV, and researchers measure…

This study looked at the long-term safety and effectiveness of Benlysta, a medication for systemic lupus erythematosus (SLE), in over 1,500 patients in everyday medical practice. Researchers tracked participants for 52 weeks, monitoring side effects, disease activity, and quality…

This study tested an oral medication called GLPG3667 in 186 adults with active systemic lupus erythematosus (SLE). Participants took the drug or a placebo once daily for 48 weeks. The goal was to see if the drug could reduce lupus disease activity and improve symptoms, while moni…

This study tested two experimental drugs, VAY736 and CFZ533, in 107 adults with systemic lupus erythematosus (SLE). The goal was to see if these drugs could reduce lupus symptoms and allow patients to lower their steroid use. Participants received either one of the drugs or a pla…

This study looked at whether adding belimumab to standard treatment is safe and effective for Chinese children aged 5 to 17 with active lupus. 67 participants received belimumab plus their usual therapy. The main goal was to check for serious side effects and see if lupus disease…

This study looked at whether the drug anifrolumab, when added to standard lupus treatments, can reduce long-term organ damage compared to standard care alone. Researchers analyzed data from 561 adults with active lupus, comparing those who took anifrolumab in earlier trials to si…

This study tested the drug belimumab in children aged 5 to 17 with active lupus. Participants received either belimumab or a placebo alongside their usual treatments. The goal was to see if belimumab could safely reduce lupus disease activity over 52 weeks.

This early-phase trial tested a new drug called VIS171 in 61 people: first in healthy volunteers, then in patients with autoimmune diseases. The main goal was to check safety and how the body processes the drug. No results on whether it actually helps the disease are available ye…

This early-stage trial tested the safety of a new drug called NTR-1011 in 36 healthy adults and people with lupus or rheumatoid arthritis. The study aimed to find a safe dose and see how the drug behaves in the body. It is a first step toward possibly developing a new treatment f…

This early-stage trial tested a new treatment for people with severe lupus that did not get better with standard medicines. The treatment uses a patient's own immune cells, modified in a lab to target and attack faulty immune cells causing the disease. Only 3 people took part, an…

This completed Phase 2 trial tested the long-term safety of deucravacitinib (BMS-986165), a daily pill, in 261 people with systemic lupus erythematosus (SLE). Participants had already completed an earlier study and continued taking the drug to monitor side effects and lab abnorma…

This study tested whether taking coenzyme Q10 (a natural supplement) along with standard lupus treatment can improve health in children with lupus. Sixty children aged 6-16 with moderate to severe lupus took either CoQ10 or a placebo for 3 months. Researchers measured changes in …

This study tested a program where a patient navigator helped minority adults with lupus overcome barriers to care, like scheduling appointments, arranging transportation, and understanding their health. The goal was to see if this support could improve quality of life and medicat…

This early-stage study tested a drug called telitacicept in 16 children with lupus. The goal was to see how the drug moves through the body and if it helps control the disease. While not a cure, it may offer a new way to manage lupus symptoms in young patients.

This study tested the drug tofacitinib in 13 young adults aged 18 to 45 with moderate to severe lupus skin disease. The goal was to see if the drug is safe and can reduce skin symptoms. Participants took the drug for up to 76 weeks, and doctors measured how well it worked using a…

This study tested a drug called emapalumab in 33 children and adults with macrophage activation syndrome (MAS), a life-threatening immune overreaction, linked to Still's disease or lupus. The goal was to see if the drug could safely control the condition and reduce the need for h…

This study tested whether a single infusion of stem cells from donated umbilical cords could help adults with lupus that does not respond to standard treatments. 81 participants received either a low dose, high dose, or placebo infusion, while continuing their usual medications. …

This study tested an experimental drug called EG-501 for people with lupus who experience cognitive impairment, often called "brain fog." The trial involved 131 participants who received either the drug or a placebo over 14 weeks. The goal was to see if EG-501 could safely improv…

This early-stage study tested an experimental drug called SHR-2173 in 30 adults with systemic lupus erythematosus (SLE). The drug was given as multiple injections under the skin. The main goal was to see if it is safe and tolerable, and to measure how the body processes it. This …

This Phase 2 trial tested nipocalimab, an intravenous drug, in 228 adults with active systemic lupus erythematosus (SLE). Participants received either nipocalimab or a placebo, alongside standard treatments. The main goal was to see if nipocalimab could reduce lupus disease activ…

This study tested an experimental drug called enpatoran in 456 people with lupus, a chronic autoimmune disease. Participants took either a low, medium, or high dose of enpatoran or a placebo for 24 weeks. The goal was to see if the drug safely reduces skin and overall disease act…

This study looked at how well flu vaccines (seasonal and H1N1) work in 234 adults with autoimmune diseases like lupus or vasculitis, some of whom were on steroids or immunosuppressants. Researchers measured antibody levels three weeks after each shot to see if the vaccine provide…

This study tested a new drug called KZR-616 (zetomipzomib) in 69 people with lupus, some of whom also had kidney inflammation (lupus nephritis). Participants received weekly injections for 13 or 24 weeks. The main goals were to check safety and see if the drug could reduce protei…

This study tested whether taking probiotics (beneficial bacteria) can help people with active lupus, an autoimmune disease. Forty adults with lupus took probiotics to see if it would reduce disease activity and improve their quality of life. The goal was to find a simple, safe wa…

This study looked at how a lupus medicine called belimumab works in Chinese children aged 5 to 17 who had already received the IV form for 48 weeks. The goal was to check the drug levels in the blood and see if switching to a shot under the skin is safe. Sixteen children took par…

This study tested four doses of cenerimod, a daily pill that calms the immune system, against a placebo in 427 adults with moderate-to-severe lupus. The main goal was to see if cenerimod could reduce lupus disease activity over six months. Researchers also checked for safety and …

This study tested a new drug called cenerimod in 105 people with systemic lupus erythematosus (SLE), an autoimmune disease. The goal was to see if the drug could safely lower certain immune cells (lymphocytes) in the blood, which may help control the disease. Participants continu…

This study tested a nurse-led care management program for lupus patients at high risk of missing appointments or ending up in the emergency room. Nurses received special training on lupus and social barriers to care, then reached out to patients to help them attend rheumatology v…

This study tested two ways to give pneumococcal vaccines to people with lupus, a disease where the immune system attacks the body. One group got a prime-boost strategy (two different vaccines six months apart), while the other got the standard single vaccine. The goal was to see …

This study looked at a device called GLOBAFFIN that filters antibodies from the blood to help people with autoimmune diseases. It involved 34 adults and measured how much harmful antibodies were removed and if patients felt better. The goal was to see if the device is safe and wo…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This completed study looked at whether lupus patients already taking hydroxychloroquine long-term had a lower risk of catching COVID-19 or developing severe symptoms. Researchers compared 552 patients who either took the drug or did not, using blood tests and questionnaires. The …

This study tested whether hydroxychloroquine, a drug already used for lupus, could slow or prevent the disease in 187 people who had early signs but not full lupus. Participants received either the drug or a placebo for up to two years. Researchers tracked lupus symptoms, immune …

This study tested whether practicing Qi Gong, a gentle mind-body exercise, could improve quality of life in people with systemic lupus erythematosus (SLE). Thirty-three participants took part in weekly Qi Gong sessions for six months. Researchers measured changes in physical func…

This phase 2 study tested whether JBT-101 (lenabasum) can reduce joint pain in people with systemic lupus erythematosus (SLE). 109 adults with active arthritis and at least moderate pain took either the drug or a placebo for 84 days. The main goal was to see if pain scores improv…

This study tested whether transcutaneous electrical acupoint stimulation (TEAS) — a gentle electrical pulse applied to specific points on the body — could reduce period pain and inflammation in women with autoimmune diseases like rheumatoid arthritis or lupus. Fifty-two women rec…

This study tested whether memantine, a drug used for Alzheimer's, can help with thinking and memory problems in people with lupus. About 111 adults with lupus and cognitive issues took either memantine or a placebo for 14 weeks. The goal was to see if the drug safely improves bra…

This study tested whether a simple walking program using a pedometer could help reduce fatigue and improve quality of life in people with lupus. 101 participants were randomly assigned to either a walking group with personalized step goals or a wait-list control group. The progra…

This study looked at whether a diet low in salt and sugar can reduce common side effects of corticosteroid treatment, such as weight gain, high blood pressure, and diabetes. Fifty adults with autoimmune diseases or asthma who were starting high-dose corticosteroids were randomly …

This study tested a phone-based version of the Walk With Ease program for 267 adults with arthritis, gout, fibromyalgia, rheumatoid arthritis, osteoarthritis, or lupus. Participants followed a 6-week walking program delivered by phone, and researchers measured changes in pain, ph…

This study tested whether an herbal supplement could reduce fatigue in people with lupus. 59 adults with lupus and significant tiredness took either the supplement or a placebo for 8 weeks. The main goal was to see if fatigue and disease activity improved. The results may offer a…

This completed study tested a health coach-led online program for 36 women with lupus. The program included 8 group sessions and 2 individual sessions to help participants set personal health goals and manage symptoms like fatigue, pain, and brain fog. Researchers measured satisf…

This study tested a 6-week stress management program for 30 African American adults with lupus. Half took part in group sessions while the other half received usual care. Researchers measured stress levels, saliva stress hormones, and quality of life to see if the program helped.

This study tested whether a 6-week self-management workshop, called the Chronic Disease Self-Management Program, could improve health and reduce healthcare use in African American women with lupus. Nearly 700 women from the GOAL study took part. The program covers topics like dea…

This study tested a special water-based exercise called Liuzijue in 130 children aged 7 to 15 with lupus. The goal was to see if it could improve their heart and lung fitness. The exercise was done twice a week for about an hour, including warm-ups and the main routine. Researche…

This study tested whether a device that gently stimulates a nerve in the ear (vagus nerve) can reduce fatigue in women with lupus. Fifty women aged 35 to 55 took part. Half received the real stimulation plus aerobic exercise, while the other half received a sham device plus the s…

This study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This completed study enrolled 6 adults with systemic lupus erythematosus (SLE) to collect blood, urine, saliva, stool, and tissue samples over time. The goal was to find biological markers that could predict when a patient's disease might flare up or how they might respond to tre…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study looks at whether people with chronic inflammatory rheumatism (like spondyloarthritis) or lupus who still have pain despite treatment have low vitamin C levels. Researchers will measure vitamin C in the blood and ask about pain, fatigue, and quality of life. The goal is…

This study looked at the genes inside B cells from 30 people with inactive lupus and compared them to healthy donors. The goal was to find what makes lupus B cells different, even when the disease is quiet. No treatment was given; this is a pure research study to better understan…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study tested a smartwatch and mobile app platform called Pedi@Ctivity to track physical activity in 362 adolescents, including those with chronic rheumatic disease. The goal was to collect big data and use AI to analyze activity patterns and create personalized exercise prog…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at over 13,000 people with chronic inflammatory rheumatism or autoimmune diseases who had or were suspected to have COVID-19. Researchers tracked how many developed severe COVID-19 requiring intensive care or leading to death. They also examined risk factors lik…

This study looked at tiny particles called microparticles in the blood and urine of people with lupus or scleroderma. Researchers wanted to see if these particles could help explain how these diseases work and possibly lead to better diagnosis or treatment. Over 200 adults partic…

This small pilot study looked at whether clopidogrel, a drug that stops blood clots, could lower a substance called sCD40L in people with lupus. Lupus is an autoimmune disease where the body attacks itself. The study involved 18 adults with lupus and measured sCD40L levels in the…

This study measured phytoestrogens (plant-based compounds) in the blood and urine of 63 premenopausal women with active lupus, other autoimmune diseases, or no disease. Researchers also asked about diet and measured estradiol levels. The goal was to see if these dietary compounds…

This study looked at how often people with active lupus take their medication as prescribed. Researchers measured blood levels of hydroxychloroquine in 307 patients to find out who was skipping doses. The goal was to understand how common non-adherence is, especially in those wit…

This completed study followed 73 people with autoimmune diseases like rheumatoid arthritis or multiple sclerosis who were starting treatment with rituximab. The goal was to track how many developed serious infections and to understand what factors increase that risk. Researchers …

This study looked at over 2,400 people with rheumatic diseases who take methotrexate. Researchers compared those who had standard lab monitoring to those who had fewer blood tests. The goal was to see if reduced monitoring is as safe in terms of preventing organ damage or death.

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This completed study looked at how the immune system might affect the outlook for people with pulmonary arterial hypertension (PAH). Researchers took blood and skin samples from 629 participants with different types of PAH to search for specific antibodies. The goal was to better…

This completed study surveyed 121 adults with autoimmune diseases like lupus, Sjögren's syndrome, or scleroderma. Participants filled out a questionnaire about their use of alternative medicines. The goal was to find out how common these practices are in this patient group.

This study looked at how lupus affects breathing, daily activity, and tiredness. Researchers compared 50 people with lupus to healthy volunteers using breathing tests, a 6-minute walk, and questionnaires. The goal was to find early signs of lung problems so doctors can treat them…

This 5-year study tracked over 3,000 adults with active lupus to see how safe and effective Benlysta (belimumab) is compared to standard care alone. Researchers monitored serious infections, cancers, and other side effects. The goal was to gather real-world data to help doctors a…

This study looked at how the immune system behaves in people with lupus (SLE) and mixed connective tissue disease (MCTD). Researchers measured immune cell responses and tracked disease activity over time. The goal was to better understand these long-term autoimmune diseases, whic…

This study followed 356 adults with lupus over time to see how the disease impacts their quality of life. Participants filled out questionnaires about their symptoms, fatigue, mood, and daily activities. The goal was to better understand what factors affect well-being in lupus, w…

This study tested a personalized way to reduce steroid doses in 72 lupus patients. Doctors used blood tests and regular check-ups over 3 months to safely lower prednisone. The goal was to find the best tapering schedule for each person, minimizing side effects while controlling t…

This completed study looked at anxiety about COVID-19 in 200 adults with rheumatic diseases who were already taking either biologic or conventional disease-modifying drugs. Researchers called participants and asked them to fill out a questionnaire about their coronavirus-related …

This study looked at whether video or phone visits (tele-rheumatology) work as well as in-person visits for people with rheumatic diseases like arthritis. Over 650 adults took part, and researchers measured how satisfied they were with each type of visit and which they preferred.…

This study looked at whether specially engineered versions of a natural immune protein (IL-2) can selectively boost regulatory T cells, which help calm the immune system. Researchers took blood samples from 67 people with various autoimmune or inflammatory conditions and tested t…

This completed study looked at 884 adults with lupus to understand what factors predict fatigue. Researchers measured fatigue, anxiety, quality of life, and physical activity. The goal is to build a model that helps doctors identify who is most at risk for severe fatigue, so they…

This study looked at how small molecules called microRNAs change during pregnancy in women with rheumatoid arthritis or lupus. Researchers collected blood and urine samples before and after pregnancy from 50 women to see if these changes relate to disease activity. The goal is to…

This study asked 88 Canadian adults with lupus about their quality of life, work productivity, and treatment preferences. Researchers used questionnaires to capture the real-world burden of the disease. The goal is to help doctors and policymakers better support people living wit…

This study looked at whether a specific antibody, called anti-GBM, could be a useful marker for lupus nephritis—a serious kidney complication of lupus. Researchers tested stored blood samples from 100 people with lupus (some with kidney issues, some without) and compared them to …

This study looked at 193 people with lupus nephritis (kidney inflammation caused by lupus) in five Gulf countries. Researchers collected information on their symptoms, treatments, and quality of life, but did not test any new medicine. The goal was to better understand the diseas…

This study measured two newer blood markers (calprotectin and serum amyloid protein) alongside standard tests in 20 children with juvenile arthritis and related conditions. The goal was to see if these markers could better track disease flare-ups in everyday clinic visits. The st…

This study looked at how faithfully people with lupus take their hydroxychloroquine (Plaquenil). Researchers used a simple questionnaire to measure compliance in 102 patients. The goal was to find which questions best identify those who skip doses, so doctors can catch problems e…

This study looked at genetic and immune system differences in children with lupus, a chronic autoimmune disease. Researchers collected blood samples from 271 participants to search for mutations in known lupus genes and discover new ones. The goal is to better understand what cau…

This completed study looked at data from 1,000 lupus patients and gathered expert opinions to find where diagnosis and treatment fall short. Researchers reviewed existing information, discussed with doctors, and built consensus on unmet needs. The goal is to publish findings that…

This completed study looked at 621 people with moderate to severe systemic lupus erythematosus (SLE) in Russia. Researchers collected information about their disease activity and background to better understand the condition. The study did not test any new treatment, but aimed to…

This study looked at how a special exercise approach called BETY affects people with rheumatic diseases (like arthritis) who have chronic pain. Researchers reviewed past records of 300 participants to see if BETY improved their physical function, mood, and quality of life compare…

This early-phase study tested the safety and tolerability of a new drug called LAD191 in 69 healthy adults and people with an autoimmune disease. Researchers gave single or multiple doses to see how the body processes the drug and if it causes side effects. The goal was to gather…

This study created a registry to collect medical information from 868 people with Anti-Phospholipid Syndrome (APS) and/or Systemic Lupus Erythematosus (SLE). The goal was to gather data on these conditions, not to test a new treatment. Participants were adults diagnosed with APS …

This study collected blood, saliva, stool, urine, and skin samples from 19 people with unknown or poorly understood immune system problems. The goal was to learn how different parts of the immune system work together. No treatments or drugs were tested. Participants were followed…

This completed pilot study tested whether training doctors to ask personalized questions (individuation) could improve care for Black and lower-income patients with rheumatic diseases like lupus and arthritis. Over 200 patients and their rheumatologists took part. The goal was to…

This completed study examined why people with rheumatoid arthritis (RA) and lupus have a higher risk of heart attacks. Researchers collected blood samples from 176 participants and tested how statins and adenosine A2A receptor agonists affected cholesterol balance in cells. The g…

This study tested a computerized decision-aid called SMILE that gives lupus patients information about their disease and treatment options. Nearly 1,900 adults with lupus from multiple clinics used the tool during their visits. The main goal was to see how many eligible patients …

This completed study looked at 1,000 women with autoimmune diseases (like lupus) who had a C-section. Researchers wanted to find out how many had severe bleeding (postpartum hemorrhage) and what factors increased that risk. By analyzing medical records, they hope to identify high…

This study aims to develop a more objective way to measure lupus disease activity using a blood test that analyzes gene activity. Researchers will compare this gene-based score with standard clinical assessments in 80 lupus patients. The goal is to create a non-invasive tool to b…

This study looked at how lupus, a chronic autoimmune disease, affects the emotional and social lives of 160 patients and their spouses. Researchers used interviews and questionnaires to understand the couple's experience, beliefs about the disease, and quality of life. The goal i…

This study tested a simple approach where doctors review pharmacy refill data during clinic visits and talk with patients about their medications. The goal was to see if this method is practical and acceptable for improving medication adherence in people with chronic rheumatic di…

This study looked at how a 12-week program of high-intensity interval training (HIIT) affects fitness and fatigue in 55 people with lupus. Researchers wanted to understand if certain immune system signals (interferons) change how the body adapts to exercise. Participants were ran…

This completed study looked at 32 people with known genetic changes in connective tissue genes to better understand how these changes affect overall health. Participants underwent a range of medical tests and exams over 3-5 days. The goal was to gather information, not to test a …