Neuralgia

This early-stage study tests the safety of a new gene therapy (GA) for people with severe nerve pain that hasn't improved with standard treatments. The therapy involves a one-time injection into a brain area that processes pain, combined with a pill to activate the treatment. Onl…

This study tests a small absorbable cap placed over cut nerve endings during finger amputation surgery. The goal is to prevent painful neuromas (nerve balling) that often cause chronic pain. Twenty adults who have had a traumatic finger amputation will be followed for up to a yea…

This study is translating and testing a questionnaire called PainPREDICT for Thai-speaking people with diabetes. The goal is to create a mobile app that can screen for painful diabetic neuropathy, a common complication that causes nerve pain. Researchers will check if the Thai ve…

About 30% of people who have surgery for a herniated disc still suffer from nerve pain afterward. This study tests whether applying a gel made from the patient's own blood (platelet-rich fibrin) around the nerve during surgery can prevent that chronic pain. The trial will enroll …

This study tests whether a type of physical therapy called explicit sensory retraining can reduce nerve pain and improve balance in people who have chemotherapy-induced peripheral neuropathy (CIPN). Participants receive either three weekly sessions of sensory retraining for the l…

This trial tests whether a steroid injection near the spine can reduce nerve pain in people with lumbosacral radiculopathy, a condition where a herniated disc presses on a nerve root. Researchers will measure pain using a standard scale before the injection and again at 3 weeks a…

This study tests whether a 12-week remote Qigong program is feasible and acceptable for adults with spinal cord injury who have chronic neuropathic pain. Participants will be randomly assigned to either practice Qigong via video or complete a short daily pain survey. The goal is …

This study tests whether psilocybin (the active ingredient in magic mushrooms) is safe and tolerable for veterans with spinal cord injury who also have depression. Thirty participants will receive low, medium, or high doses and be monitored for side effects like pain, muscle spas…

This trial tests whether taking Ceylon cinnamon supplements for six months can reduce pain and improve blood sugar, cholesterol, and body weight in adults with painful diabetic peripheral neuropathy. Participants are randomly assigned to receive either cinnamon capsules or a plac…

This study tests a new drug called (2R,6R)-hydroxynorketamine (HNK) for chronic nerve pain in the arms or legs. 25 adults will receive a single infusion of HNK, ketamine, or a placebo in random order, with 5 weeks between each. Researchers will measure pain levels, sleep, and dai…

This study tests whether shining a special laser light on painful areas can reduce nerve pain caused by chemotherapy. About 70 cancer survivors with lasting nerve pain will receive either real or placebo laser treatments. The goal is to see if this safe, non-drug approach can imp…

This study is testing a self-hypnosis program that runs on a virtual reality headset to help people with HIV manage chronic pain. About 25 adults with HIV and long-term pain will use the software at home for 21 days. Researchers will check if it is safe, easy to use, and if it he…

This phase 3 trial tests whether an extended-release (once-daily) form of pregabalin works as well as the standard immediate-release (twice-daily) form for relieving nerve pain caused by diabetic peripheral neuropathy or postherpetic neuralgia. About 348 adults aged 18 to 75 with…

This study tests two different injection locations for a nerve block to treat chronic low back and buttock pain caused by a trapped nerve. 54 adults with pain lasting over 3 months will receive an ultrasound-guided injection of numbing and anti-inflammatory medicine. The goal is …

This early-stage study tests whether a new drug called EC5026 is safe and can reduce nerve pain in people with spinal cord injury. About 36 adults with pain from traumatic or non-traumatic spinal cord injury will take either the drug or a placebo daily for 14 days. Researchers wi…

This study tests whether a supplement called Normast3 can reduce nerve pain and improve nerve function in adults with diabetic polyneuropathy, a common complication of diabetes. About 40 participants will take either Normast3 or a placebo twice daily for 12 weeks, while researche…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain, depression, and sleep problems in people with spinal cord injury. Researchers will compare two different rTMS protocols against a placebo in 63 adults. Participants continue the…

This study looks at whether a high-dose capsaicin patch (made from chili pepper extract) can relieve long-lasting tailbone pain that hasn't responded to other treatments. Researchers will review medical records from 106 patients treated over six years to see how well the patch wo…

This study is testing a new type of spinal cord stimulator that automatically adjusts its signal based on how your nerves respond. It aims to improve pain relief and quality of life for 25 adults with long-term, hard-to-treat pain in the trunk or limbs. The device is already appr…

This early-stage study tests whether a new drug called ASCT-83 is safe for people with nerve pain. It involves 72 healthy adults who will receive either the drug or a placebo. The study will also measure how the drug moves through the body. Results will help decide safe doses for…

This study tests a newer way to give epidural steroid injections for people with long-term leg pain caused by nerve issues. It compares the new 'transgrade' method to the standard 'interlaminar' method. The goal is to see which approach provides better pain relief three months af…

This study tests whether a capsaicin 8% patch (made from chili pepper extract) can reduce chronic nerve pain in teenagers aged 12 to 17 who have had pain for over 3 months after surgery or injury. Half the teens get the real patch, the other half get a placebo dressing. Pain leve…

This small study tests whether a gentle, non-invasive brain stimulation technique called tACS can reduce nerve pain in people with spinal cord injury. Fourteen participants will receive either real or sham stimulation for 20 minutes. Researchers will measure pain levels and heart…

This study tests whether a gel containing pregabalin, applied through the skin using ultrasound (phonophoresis), combined with calf muscle stretching, can reduce nerve pain and improve walking in people with grade III knee osteoarthritis. The trial includes 35 adults aged 40-70 w…

This study tests a device called the Sana Pain Reliever, a mask with earbuds that delivers pulses of light and sound for 15 minutes at a time. Researchers want to see if it can reduce chronic pain and improve sleep in people with post-treatment Lyme disease syndrome. The trial in…

This study is testing whether different types of NSAIDs (like ibuprofen, diclofenac, and meloxicam) work better for specific pain types in people with frozen shoulder. 120 adults with shoulder pain and stiffness will take one of these drugs along with home exercises for two weeks…

This study tests whether giving calcitonin early after a spinal cord injury can lower the chance or severity of nerve pain. About 126 adults with a recent spinal injury will receive either calcitonin or a placebo. Researchers will track pain levels and side effects for up to a ye…

This study looks at whether adding ultrasound-guided shoulder injections to a home exercise program can reduce pain and improve movement in people with frozen shoulder. About 68 adults with chronic shoulder pain will receive either one type of injection or a combination, and be f…

This study compares two numbing drug recipes for a nerve block given before leg surgery. One group gets a mix of lidocaine and bupivacaine, while the other gets bupivacaine alone. Researchers want to see which combination works faster and provides better pain control after the op…

This study tests whether combining brain stimulation (rTMS) with virtual reality mirror therapy can reduce hard-to-treat nerve pain. 64 adults with chronic neuropathic pain that hasn't responded to drugs will receive either real or sham mirror therapy alongside rTMS. The goal is …

This study tests whether combining spinal cord stimulation with a rehabilitation program can reduce chronic nerve pain in the legs and improve physical function. Ten adults aged 18-60 with nerve pain lasting over 6 months will receive the treatment bundle. The goal is to see if t…

This study tests a new type of deep brain stimulation called 'Burst-DBS' for people with long-term facial pain or pain after a stroke. Twenty adults will have electrodes placed in the thalamus (a pain-related brain area) and try both standard and burst stimulation patterns. The g…

This study tests whether eye drops made from cord blood plasma can reduce pain in people with long-term nerve-related eye pain. Twenty adults with persistent eye pain and abnormal corneal nerves will receive the drops. Researchers will measure pain levels and nerve health to see …

Stanford University is testing a non-invasive device that uses pulsed radiofrequency to treat chronic nerve pain after injury. The device sends magnetic pulses through the skin to target the affected nerve. This Phase 2/3 trial will enroll 95 adults to see if the treatment reduce…

This early study tests a small device that sends gentle electrical pulses to nerves to relieve severe, long-lasting knee, elbow, or shoulder pain. About 30 adults with chronic pain will first try a temporary implant for up to 8 hours. If it works well, they can get a permanent ve…

This study tests a gel called VMD-3866 for pain from chemotherapy-induced peripheral neuropathy (CIPN). It is applied to the skin and works by blocking pain signals in nerves. The trial includes 16 adults with stable CIPN pain for at least 3 months. Researchers compare the gel to…

This study tests a non-invasive brain stimulation technique called deep rTMS to see if it can reduce chronic pain from nerve damage or fibromyalgia. About 70 adults with daily pain will receive either real or fake (sham) treatment over 3 months. The goal is to measure pain relief…

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce pain and improve daily life for people with post-herpetic neuralgia (long-term nerve pain after shingles). About 34 adults aged 35-65 with persistent pain will receive the sti…

This study compares two ways to block pain during lung surgery (VATS) to see if they can prevent chronic pain that lasts for months. Forty adults having planned lung surgery will receive either an ultrasound-guided nerve block or a surgeon-given block. Researchers will track pain…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce nerve pain in people with spinal cord injury. Sixty adults will receive either real or sham rTMS daily for 15 sessions while continuing their usual pain medications. Pain levels will be mea…

This phase 2 trial is testing whether cannabis-based medicines—THC, CBD, or a combination—can safely reduce chronic nerve pain in Veterans. 320 participants will receive one of these treatments or a placebo for six weeks. The goal is to see if these options offer better pain reli…

This study compares two treatments for long-lasting nerve pain after shingles (postherpetic neuralgia). Researchers will give 50 adults either a nerve block or a radiofrequency treatment and measure pain levels. The goal is to find which option works better for easing this stubbo…

This study tests whether a high-dose capsaicin patch (made from chili pepper extract) can reduce chronic tailbone pain (coccygodynia) better than a low-dose patch. About 188 adults with pain lasting over 3 months will receive either the 8% patch or a control patch applied once fo…

This study tests whether magnetic pulses to the brain (TMS) can ease nerve pain that won't go away with standard drugs in people with spinal cord injury. 39 adults with pain for at least 6 months will receive either real or sham TMS to the motor cortex or the anterior cingulate c…

This study in Ukraine compares two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to treat nerve pain caused by neuromas from combat injuries. Fifty adults with moderate to severe pain will be randomly assigned to one treatment. The go…

This study looks at whether a surgery called RPNI can reduce nerve pain in people who have had a leg amputated. The surgery takes the cut nerve end and wraps it in a small piece of the patient's own muscle to help it heal. Researchers will follow 20 adults for 24 months to see if…

This study tests whether a spinal cord stimulator—a device that sends mild electrical pulses to the spine—can reduce pain and improve blood flow in the legs of people with type 2 diabetes who have nerve pain. Researchers will enroll 25 adults with painful diabetic neuropathy and …

This study tests two minimally invasive procedures—cryoablation (freezing) and radiofrequency ablation (heating)—to control severe chest pain after combat injuries. About 50 adults in Ukraine will be randomly assigned to one treatment, and researchers will measure pain levels, op…

This study tests a new, faster type of brain stimulation (called AiTBS) to see if it relieves nerve pain better than the standard method. 120 adults with long-term nerve pain will receive either AiTBS or standard stimulation over 10 days. Researchers will measure pain levels and …

This study tests whether a virtual walking therapy can reduce chronic nerve pain in people with spinal cord injury. Participants will watch a life-sized video of themselves walking through a forest while seated in a tilting wheelchair. The trial will enroll 40 adults and compare …

This study tests whether taking two dietary supplements (PEA and Scutellaria) along with a structured exercise program can reduce nerve pain and damage caused by chemotherapy. About 40 adult cancer survivors who have nerve pain will be followed for 60 days. The goal is to see if …

This study tests whether a 12-week progressive resistance exercise program can reduce chronic pain in people with multiple sclerosis. 116 participants will be randomly assigned to either the exercise group or a waitlist control group. The goal is to see if exercise provides a mea…

This pilot study tests whether scrambler therapy, a device that uses mild electrical signals on the skin, can reduce nerve pain in people with corticobasal syndrome (CBS). Twenty-five adults with CBS and moderate-to-severe pain will be randomly assigned to receive either scramble…

This study tests whether taking ginger root extract daily for 8 weeks can reduce pain and improve gut health in people with chronic sciatica. Researchers will measure pain levels, gut bacteria, and brain changes in 80 adults. The goal is to see if ginger affects the gut-brain con…

This study is testing whether a closed-loop spinal cord stimulator can reduce pain and improve quality of life in people with nerve damage from chemotherapy. The device automatically adjusts stimulation based on nerve responses. Twenty adults with persistent pain will be followed…

This study tests whether playing a virtual reality walking game at home can help reduce neuropathic pain in adults with chronic spinal cord injury. 250 participants with complete injuries will use a VR headset to see virtual legs walking from a first-person view. They will play t…

This study tests whether playing a virtual reality walking game at home can reduce neuropathic pain in adults with incomplete spinal cord injury. Participants will use a headset to see virtual legs and walk in a virtual world for about 30 minutes twice daily over 10 days. The goa…

This study tests whether combining bodily illusions (like the rubber hand illusion) with mild brain stimulation (tDCS) can reduce neuropathic pain in people with spinal cord injury. Thirty participants will undergo 10 sessions over 2-4 weeks. The goal is to see if these technique…

This study tests whether deep brain stimulation (DBS) can safely reduce severe, long-lasting pain after a stroke. Thirty adults with pain that hasn't improved with other treatments will have a DBS device surgically implanted. Over 10 months, researchers will compare different sti…

This study tests whether training a spinal reflex can reduce neuropathic pain in people with spinal cord injury. Fifteen participants will undergo about 50 sessions of reflex training over 6.5 months. The goal is to see if changing this reflex can lower pain and improve sensation…

This study tests a safe, home-use device that sends mild electrical current to the brain (tDCS) to help people with long-term pain who only got short-term relief from a similar hospital treatment. About 70 adults with chronic nerve or pain-sensitization pain will use the device 2…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce chronic nerve pain in people with cancer. Sixty participants will receive both real and sham (placebo) stimulation in a crossover design, with an 8-week break in between. The goal is to see…

This study tests whether adding ozone therapy to standard care can reduce nerve pain caused by chemotherapy. 42 adults with cancer and persistent nerve pain will receive either ozone or oxygen gas via rectal insufflation for 16 weeks. The main goal is to see if pain and quality o…

This study will check if certain blood markers can predict how well a nerve block procedure works for people with nerve pain. Researchers will measure pain levels and blood inflammation markers before and after the procedure in 120 adults. The goal is to see if these blood tests …

This study looks at how the location of brain-stimulating electrodes affects pain relief in adults with long-term nerve pain that hasn't improved with other treatments. Researchers will use brain scans to see which areas are activated and how that relates to pain reduction. The g…

This study follows 250 people who had ankle fractures to see how many develop nerve-related chronic pain after the bone heals. Participants answer pain questionnaires and undergo simple sensory tests. The goal is to better understand this type of pain, not to test any new treatme…

This study follows 50 children who had a nerve-freezing procedure (cryoneurolysis) before surgery to correct a sunken chest (pectus excavatum). Researchers check for long-term nerve pain, quality of life, and sensory recovery using questionnaires. The goal is to see if the pain r…

This study looks at how spinal cord stimulation (SCS) affects brain activity in veterans with long-term nerve pain. Researchers will use non-invasive brain scans (fNIRS and EEG) to compare brain connectivity in SCS users and those being evaluated for SCS. The goal is to understan…

This study looks at why some people develop nerve pain after a spinal cord injury. Researchers will use pain tests, nerve measurements, and heart rate checks in 300 participants to understand the underlying causes. The goal is to better classify pain types, not to test a new trea…

This study looks at people with shoulder pain lasting at least 3 months to understand if nerve-related pain and a condition called central sensitization (where the nervous system becomes overly sensitive) play a role. Researchers will use questionnaires and simple movement tests—…

This observational study follows 75 people with shoulder impingement syndrome who are already receiving standard physical therapy. Researchers want to see if nerve-related pain and negative thinking about pain (called pain catastrophizing) affect how well patients stick to their …

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study looks at children and teens who had a limb removed before age 15-16 to see if they experience nerve pain (phantom limb or stump pain). Researchers will review medical records and use questionnaires during regular check-ups. The goal is to better understand how common t…

This observational study is gathering data from 150 adults with muscle or joint pain to see how their answers on a pain questionnaire (PainDETECT) relate to where it hurts and their official diagnosis. Researchers hope to better understand when nerve pain is involved in common mu…

This study aims to find out how many people with knee osteoarthritis also have nerve-related pain, and whether that type of pain makes their symptoms and daily function worse. Researchers will measure pain and physical ability in 102 participants using standard questionnaires. Th…

This study looks at two types of spinal cord stimulation for people with long-term nerve pain after back surgery. One type causes a tingling sensation, while newer types do not. Researchers will use brain scans and pain questionnaires to figure out how each type works and which p…

This study is testing a new tool called CANoPy that predicts whether a cancer patient will develop long-term nerve pain. Researchers will follow 625 adults with breast, gynecological, colorectal, or lung cancer as they undergo treatments like chemotherapy or surgery. By collectin…

This study uses a smartphone app called SOMA to track daily mood, pain, and activity in 800 people with acute or chronic pain over four months. The goal is to find patterns that predict whether acute pain becomes chronic, or if chronic pain flares up. A smaller group will also ha…

This study looks at nerve-related problems like numbness, tingling, and pain in people who have been treated for oral cavity or throat cancer. Researchers will use simple tools like brushes and temperature tests to map these sensations. The goal is to better understand how common…

This study looks at how spinal cord stimulation (SCS) changes certain molecules in the blood and spinal fluid of people with long-term nerve pain. Researchers will measure inflammatory markers and other signaling molecules before and after SCS in 30 adults. The goal is to underst…