Disorder of ear

This study tested whether miconazole oil can cure fungal ear infections (otomycosis). 112 adults with ear fungus received either the active oil or a placebo for 14 days. Neither patients nor doctors knew who got the real treatment. After two weeks, doctors checked if the infectio…

This study tested a new vaccine called V114 in over 7,000 healthy infants to see if it could prevent ear infections caused by certain pneumococcal bacteria. The vaccine was given alongside routine childhood shots. Researchers tracked how many babies got vaccine-type ear infection…

This early-stage trial tested whether a new whole-cell pneumonia vaccine is safe for people. Thirty healthy adults received either the vaccine or a placebo and were monitored for 30 days. The main goal was to check for side effects like pain, fever, or headache. This study does n…

This study tested an experimental drug called SPI-1005 (ebselen) in 254 adults with Meniere's disease, a condition causing hearing loss, ringing in the ears, and dizziness. Participants received either the drug or a placebo for a set period, followed by an open-label phase where …

This study tests whether SPI-1005, a drug containing ebselen, can prevent hearing loss in people with cystic fibrosis who are receiving IV tobramycin for a lung infection. About 40 participants will receive either a placebo or one of three doses of SPI-1005 for 21 days. Researche…

This study tested whether using a patient's own platelet-rich plasma (PRP) during eardrum repair surgery improves healing. 48 adults with chronic ear infections and eardrum holes were split into two groups: one got PRP-soaked sponges placed in the ear during surgery, the other go…

This study tested a new cochlear implant (CI632) in 10 adults who have some low-frequency hearing but poor high-frequency hearing. The goal was to see if the implant improves speech understanding and overall hearing. Participants received the implant and were followed to measure …

This early-phase trial tested a special insulin gel applied directly to the ear drum after surgery to repair a long-standing hole. Fifty adults with dry ear drum perforations received either the insulin gel or a plain foam control. The insulin group showed significantly better he…

This study tested whether dornase alfa (Pulmozyme) ear drops can unclog tympanostomy tubes in children better than standard ofloxacin drops. 41 children aged 1 to 18 with clogged tubes received either treatment for 7 days. The main goal was to see if the tube was open at day 14.

This study compared two ways of preparing a tissue graft (temporalis fascia) for repairing holes in the eardrum caused by chronic ear infections. 92 adults aged 18–60 received either a wet or dry graft during tympanoplasty surgery. Researchers checked hearing improvement and graf…

This study compared two ear drop treatments for otomycosis, a fungal infection of the outer ear that causes itching, discharge, and blockage. Sixty patients were randomly assigned to receive either clotrimazole or 2% salicylic acid drops three times daily for two weeks. The main …

This study tested two common treatments for fungal ear infections: boric acid and povidone iodine. Sixty patients were treated with one of the two solutions applied directly to the ear canal. The goal was to see which one clears the infection better and reduces symptoms like pain…

This pilot study from France tested two ways to treat otosclerosis, a condition that causes hearing loss. Thirty people first used a hearing aid for at least two months, then had surgery to fix the middle ear bone. Researchers measured quality of life after each treatment to see …

This study compares two surgical techniques for repairing large eardrum holes caused by chronic ear infections. The interlay method places the graft between eardrum layers, while the underlay method places it beneath. Researchers measured hearing improvement in 60 adults to see w…

This study tested the safety of taking rimegepant every day to prevent episodic migraines. 441 adults with a history of migraines took a daily 75mg tablet for up to 52 weeks. Researchers tracked side effects and lab changes to see if long-term daily use is safe and tolerable.

This study tested a wearable device that tracks eye movements during dizzy spells to help doctors tell apart three common inner-ear conditions: Ménière's disease, vestibular migraine, and BPPV. Four adults wore the device for 30 days to capture data. The goal was to develop a com…

This study tested a new MRI technique to detect endolymphatic hydrops (fluid buildup) in the inner ear of people with Meniere's disease. The new method uses a special 3D FLAIR sequence without contrast dye, compared to the standard method that requires an injection. The goal was …

This study tested a low-cost, smartphone-connected device that checks middle ear health. Researchers compared it to standard equipment in 30 adults and children. The goal is to make ear screening affordable and easy for rural communities, reducing preventable hearing loss.

This study tested whether a special eye-tracking device (video-oculography) helps emergency room doctors more accurately diagnose the cause of vertigo or dizziness. About 130 adults with dizziness were randomly assigned to get either the eye-tracking test plus standard care, or s…

This pilot study tested whether a smartphone app can accurately measure gaze stability and the vestibulo-ocular reflex (VOR) in adults with and without balance disorders. 35 participants performed standard balance tests using both a smartphone app and a commercial computer system…

This study tests an experimental drug called SPI-1005 (ebselen) in adults with Meniere's disease, a condition that causes vertigo, tinnitus, and hearing loss. The trial compares three doses of SPI-1005 against a placebo to see if it safely reduces these symptoms. Researchers will…

This study investigates whether a beetroot powder jelly candy can help competitive swimmers swim faster and feel less tired. Beetroot is rich in nitrate, which the body converts to nitric oxide, a compound that may improve blood flow and muscle efficiency. The trial involves 21 s…

This study tested a balloon catheter to open blocked Eustachian tubes in 31 adults. The device is inserted into the tube and inflated to widen it. Researchers measured changes in ear symptoms over 14 months to see if the procedure provides lasting relief.

This study tested whether changing how fast pressure increases during hyperbaric oxygen therapy (HBOT) can lower the chance of ear pain and injury. Over 1,500 people receiving HBOT were randomly assigned to one of two compression schedules. The goal was to see if a non-linear (sl…

This study tested whether laser acupuncture, a painless procedure using low-level laser light on specific points, can improve middle ear function in children aged 2-10 with otitis media with effusion (fluid behind the eardrum). Thirty-two children received either real or sham las…

This study tested three different balance exercise programs in 45 adults with dizziness from a chronic inner ear condition. One group did standard head and eye exercises, another watched 2D moving patterns, and a third used 3D virtual reality. All groups practiced for 6 weeks, an…

This study tested whether a home-based balance therapy program is practical for children aged 4-17 with inner-ear problems that cause dizziness and balance issues. Twenty-one children did balance exercises at home for 8 weeks, with weekly check-ins from a physical therapist. The …

This study tested whether playing WiiFit games is more effective than standard balance exercises for people with dizziness and balance problems caused by inner ear issues. 42 adults aged 18-65 took part in a 4-week program. The goal was to see if the fun, interactive nature of Wi…

This study tested two types of eye exercises—gaze stabilization and optokinetic training—in 32 adults aged 35-55 with chronic dizziness from inner ear problems. The goal was to see which better improves dizziness, balance, and confidence in daily activities. Results help guide th…

This study tested whether eye and neck exercises can reduce dizziness and uncontrolled eye movements in young adults with benign paroxysmal positional vertigo (BPPV). Fifty-six participants did either eye exercises alone or combined eye and neck exercises for six weeks. The goal …

This study tested whether a device called AirOFit PRO, which guides children through blowing exercises, can help clear fluid behind the eardrum. Fifty-one children with otitis media with effusion (OME) used the device three times daily. The goal was to see if the exercises improv…

This study tested a device called SinuSonic that combines sound vibrations with gentle pressure to help people with Eustachian tube dysfunction (ETD) and facial pain. Thirty adults used the device twice a day for six weeks. Researchers measured changes in symptoms like ear pressu…

This study tested whether a smartphone app helps people with dizziness do their prescribed balance exercises more consistently. Thirty adults with various vestibular disorders were randomly assigned to use the app or keep a paper diary. The researchers measured how often particip…

This study looked at two ear sprays—Ectoin Ear Spray and Normison Ear Spray—to see how well they work and if they are safe for people with chronic itching and skin irritation of the outer ear canal. 60 adults took part in this real-world observation. The main goal was to check if…

This study looked at whether taking statins (cholesterol-lowering drugs) can reduce hearing loss caused by platinum-based chemotherapy in people with solid tumors. 56 adults who were about to start chemotherapy took part. The goal was to see if statins could protect their ears fr…

This study looked at whether placing small tubes in the ears of children aged 1-4 with chronic ear fluid (otitis media with effusion) improves their sleep and quality of life. Sixty children were randomly assigned to either receive ear tubes or not. Sleep was measured with a wris…

This study tested a 4-week virtual reality exercise program to help people who get motion sickness from visual cues, like in VR or certain videos. 46 adults, some with and some without motion sickness, took part. The program used 360-degree travel videos in a VR headset to gradua…

This study tested a daily dietary supplement called ACEMg (Soundbites) in 64 adults with hearing loss or tinnitus. Participants took the supplement for 24 weeks and completed hearing tests and symptom surveys at home using a smartphone app. The goal was to see if the supplement c…

This study tested different doses of liposomal bupivacaine, a long-lasting numbing medicine, in 55 adults having shoulder surgery. The goal was to find the smallest dose that still blocks pain but lets patients move their arm. Researchers used a special method where each patient'…

This completed study tested whether adding gastrodin acupoint injections to standard care helps people with sudden hearing loss and vertigo. One hundred adults received either standard therapy alone or standard therapy plus injections into specific acupuncture points over four we…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study tested whether using a virtual reality headset is as good as standard equipment for improving balance in people with vertigo. 76 adults with vestibular disorders completed a 3-4 week rehabilitation program. The goal was to see if the cheaper, smaller VR device could ma…

This pilot study tested a virtual reality system called DizzyVR for rehabilitating people with dizziness from inner ear disorders. Ten adults used the system for eight weekly sessions. The goal was to see if it was easy to use, safe, and enjoyable, and to gather early data on whe…

This study looked at 73 people with otosclerosis who had stapes surgery using bone cement to fix the middle ear bones. The goal was to see if bone cement helps improve hearing over the long term. Researchers measured both conductive and sensorineural hearing changes with hearing …

This study tested two drugs used to reverse muscle relaxants after surgery: sugammadex and a combination of neostigmine and glycopyrrolate. The goal was to see which one better prevents urinary retention in 124 patients having ear, nose, or throat surgery who were at high risk du…

This study tested whether a low dose of tranexamic acid, a drug that helps blood clot, could reduce bleeding during middle ear surgery. 100 adults undergoing microscopic or endoscopic ear surgery received either the drug or a placebo. The goal was to see if the drug improved the …

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This study aims to find the genetic causes of hereditary hearing loss and balance disorders. Researchers will study families with these conditions, collecting medical history, blood or cheek swabs, hearing and balance tests, and sometimes scans. The goal is to identify genes and …

This study compared two imaging methods—PET/CT and labeled leukocyte scintigraphy—for monitoring malignant otitis externa, a serious infection of the ear canal that can spread to the skull. Researchers looked at 18 patients who had both scans before and after antibiotic treatment…

This study looked at whether giving doctors education and feedback, a special digital otoscope, or both could help them avoid prescribing antibiotics for ear infections that don't need them. Forty pediatric clinicians who often prescribed antibiotics for ear infections were split…

This study looked at how to improve care for dizzy patients in the emergency department. Over 90,000 adults participated. The goal was to help doctors use proven tests and treatments for common causes of dizziness like BPPV. The study tested new training and tools to make sure pa…

This completed study tested three different intensities of gentle neck movements designed to stimulate the vagus nerve in 128 healthy adults. Researchers measured changes in heart rate, balance, pain sensitivity, and digestion (via stool samples). The goal was to find the best 'd…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This study looked at whether hearing and vision loss are linked to delirium (sudden confusion) in older hospital patients. Over 1,500 participants answered screening questions and had their hearing and vision tested. In a smaller trial, researchers tested if posting communication…

This study looked at 52 adults with dizziness and balance problems from a one-sided inner ear disorder. Researchers measured how well people functioned before and after a standard balance therapy program. The goal was to see if things like dizziness severity or personal factors c…

This completed study enrolled 186 people with mild to moderate hearing loss to understand how damage to inner ear sensory cells and auditory neurons affects speech understanding, especially in noisy environments. Participants were fitted with hearing aids and tested on speech rec…

This study looked at 98 adults with severe-to-profound hearing loss to see if they also have balance problems. Since the inner ear controls both hearing and balance, researchers used special tests to measure how well the balance system works. The goal was to understand if hearing…

This study tested a program to help doctors prescribe antibiotics more appropriately for common childhood infections like earaches, sore throats, and sinusitis. Over 1,000 doctors took part, receiving online training, personalized feedback on their prescribing habits, and support…

This study checked whether hot air balloon pilots, who are exposed to burner noise and air pressure changes, have more hearing, eustachian tube, or balance problems than other adults. About 105 pilots and non-pilots took part in safe, non-invasive hearing and balance tests. The g…

This completed study surveyed 250 adults with vestibular disorders (like vertigo) across Belgium, France, and the US. Participants filled out questionnaires about dizziness, anxiety, and thinking problems, while doctors provided routine test results. The goal is to link symptoms …

This completed study looked at whether medications used for COVID-19 or the COVID-19 vaccine can harm hearing. Researchers compared hearing test results among 90 adults aged 18-35: those who had COVID-19 and took medications, those who had COVID-19 but took no medications, and a …

This study tested whether giving doctors automated reports on their antibiotic prescribing habits could improve how often they follow official guidelines. Researchers looked at over 26,000 patients with pneumonia, ear infections, or sore throat. They compared antibiotic use befor…

This study looked at how two common seasickness drugs (scopolamine and meclizine) change inner ear balance tests in 54 healthy soldiers who get seasick. Researchers measured eye movements before and after taking the drugs to see if these tests could predict which drug works best …

This study from the University of Zurich looked at how people with different neurological conditions walk. Researchers measured walking patterns in 208 adults, including those with stroke, Parkinson's, multiple sclerosis, and spinal cord injury, as well as healthy volunteers. The…

This study tested a French version of a questionnaire that measures dizziness symptoms in children aged 7 to 17. Researchers asked 85 kids with and without balance issues to fill out the survey twice, two weeks apart. The goal was to see if the translated questionnaire is reliabl…

This study looked at 20 people with long-term balance problems caused by inner-ear damage. Researchers wanted to see if fast, unconscious eye movements called 'covert saccades' help them see clearly when moving their head. Participants had their eye movements measured during quic…

This study tested whether healthy volunteers with minimal training could collect their own blood using a finger prick during brief periods of weightlessness on parabolic flights. The goal was to see if the blood samples were good enough to measure caffeine levels. Thirty particip…

This completed study tested whether a virtual reality training program could improve the ability to locate sounds in people with hearing loss. 79 participants performed sound localization tasks with and without visual feedback. The goal was to see if training could reduce pointin…