Inner ear disorder

This study tests whether programming a cochlear implant based on each person's unique inner ear structure improves hearing compared to the standard one-size-fits-all approach. Adults with severe to profound hearing loss who already have a MED-EL cochlear implant will receive both…

This study tests a drug called SPI-1005 in 200 adults with Meniere's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Participants will take the drug twice a day for 6 or 12 months to see if it is safe and tolerable. The goal is to find a treatme…

This phase 2 trial tests whether anakinra (Kineret), an anti-inflammatory drug, can improve hearing in people with Meniere's disease or autoimmune inner ear disease who cannot take steroids. About 57 participants will receive daily injections of anakinra or a placebo for 42 days,…

This study tests whether Yiyuancong, a traditional Chinese medicine made from food-like ingredients, can help people with sudden hearing loss. About 128 adults aged 18-60 will take the formula for 1-2 months, and their hearing will be measured with standard tests. The goal is to …

This study follows 15 adults (ages 22–90) with severe, long-term balance disorders caused by inner ear damage. Participants have already received a vestibular implant, a device that electrically stimulates the balance nerve to help restore steadiness and clear vision during movem…

This study tests a vestibular implant in 15 older adults (ages 65-90) with chronic balance issues due to bilateral vestibular hypofunction. The implant electrically stimulates the inner ear to improve balance and vision. Researchers will measure changes in gait and eye reflexes o…

This study tests a vestibular implant, a device surgically placed in the inner ear to electrically stimulate balance nerves. It aims to improve balance, posture, and vision in up to 8 adults with bilateral vestibular hypofunction, a condition causing chronic dizziness and instabi…

This study is testing an experimental device called a vestibular implant, which is surgically placed behind the ear to stimulate the balance nerve. The goal is to see if it can improve walking and balance in adults with long-term dizziness that hasn't improved with other treatmen…

This study tests the drug belzutifan in 100 people with von Hippel-Lindau (VHL) syndrome, a genetic condition that causes tumors in various organs. Researchers will track how well the drug shrinks tumors and how long it takes for the disease to progress, while also monitoring sid…

This study tests whether the drug ORC-13661 can prevent hearing loss in people receiving intravenous amikacin for a lung infection called NTM. About 105 adults will take either a high dose, low dose, or placebo daily for up to 90 days. Researchers will compare hearing changes amo…

This study tests whether acetylcysteine, a drug often used for other purposes, can prevent hearing loss caused by cisplatin chemotherapy. About 40 adults receiving high-dose cisplatin will get either acetylcysteine or a placebo after each chemo session. Researchers will measure h…

This study tests a new treatment called ACTIVE that combines counseling (Acceptance and Commitment Therapy) with balance exercises for people with mild traumatic brain injury. Researchers want to see if it helps reduce dizziness and anxiety better than standard balance therapy al…

This study tests a small, TENS-like device that sends a mild electric signal to improve balance and walking in older adults. Researchers will measure walking speed and stability in 120 participants aged 60 and older, as well as younger adults for comparison. Participants will wal…

This study tests whether a combination of two existing drugs, nortriptyline and topiramate, can reduce vertigo and other symptoms in people with Meniere's disease. Forty adults with active Meniere's will take the drugs or a placebo for 8 weeks. The goal is to see if this approach…

This study tests whether a simple head-and-body movement called the Epley maneuver can quickly relieve dizziness from benign paroxysmal positional vertigo (BPPV) in the emergency department. About 118 adults with BPPV will either get the real maneuver or a fake one. Researchers w…

This study is testing whether changing the low-frequency settings on a cochlear implant can improve hearing for people who are deaf in one ear but have normal hearing in the other. Twenty-two adults will try four different sound maps during their first month after implant activat…

This study tests whether a special belt that vibrates can help people with balance disorders walk better and feel more steady. Researchers will enroll 90 adults aged 18-80 who have balance issues from conditions like inner ear problems or ataxia. Participants will use the belt an…

This study tests whether a 20-minute session of passive music therapy, delivered through an app just before entering the operating room, can lower anxiety and pain in adults undergoing ear, nose, or throat surgery. Five hundred participants will be randomly assigned to receive mu…

This study tests whether virtual reality exercises can help people with balance problems caused by a weak inner ear on one side. 48 adults will be split into three groups: one doing standard balance exercises, one using VR, and one doing both. The goal is to see if VR can reduce …

This study tests whether vestibular therapy—a set of head-movement exercises done with a physical therapist—can reduce falls in people with Alzheimer's disease who also have inner-ear balance problems. About 100 participants aged 60 and older will receive either the therapy or st…

This study tests whether adding neck therapy (cervical mobilization) to standard balance exercises can reduce dizziness and improve balance in people with Meniere's disease. 33 adults with Meniere's will be split into three groups: one getting only their usual medication, one add…

This study tests a new noise-reduction feature for hearing aids that uses deep neural networks to help people hear speech better in noisy settings. Fifty adults with mild-to-moderate hearing loss will listen to sentences at different noise levels while using three settings: no no…

This study looks at whether adding Brandt-Daroff exercises to the usual GANS maneuver can reduce dizziness and improve quality of life for people with BPPV, a common inner-ear condition that causes brief spinning spells. About 30 adults with BPPV will be split into two groups: on…

This study tests whether hearing aids can improve quality of life in cancer patients who develop hearing loss from platinum-based chemotherapy. Fifty-two adults currently on such chemotherapy and with confirmed hearing loss will be randomly assigned to receive a hearing aid or st…

This study tests a device called SWAN that guides people through head movements to reduce motion sickness and improve balance. It is for adults with inner ear disorders, motion sickness, or those recovering from vestibular schwannoma surgery. Participants use the device at home f…

This study aims to better understand disorders that cause hearing to fluctuate, such as Meniere's disease. Researchers will use advanced MRI scans and blood tests to look for biomarkers linked to hearing changes. The goal is to identify different types of these disorders and pave…

This study is looking at whether people with a common inner-ear condition called benign paroxysmal positional vertigo (BPPV) have lower vitamin D levels than those without it. Researchers will compare vitamin D in 160 adults — half with BPPV and half without. The goal is to see i…

This study analyzes dried blood spots from 630 newborns to find protein and RNA markers that could predict which babies with congenital CMV will develop hearing loss or other problems. Researchers will compare samples from infected babies who had complications, those who did not,…

This study looks at whether a vestibular implant (a device that helps with balance) can improve how people with severe inner ear damage perform tasks like staying upright, navigating, and thinking. About 20 people who already have the implant will be tested with it on and off, an…

This study collects medical information and samples from people with hearing, balance, taste, smell, voice, speech, or language disorders. Researchers aim to use this data for future studies and to find candidates for other research. Participants receive standard care, and no exp…

This study looks at whether a balance exercise called IVA is safe and helpful for adults who have vision problems, with or without inner-ear balance issues. Researchers will compare two groups: people with vision problems only and those with both vision and inner-ear problems. Pa…

This study is looking at whether people with benign paroxysmal positional vertigo (BPPV) have differences in their autonomic nervous system compared to healthy people. Researchers will measure heart rate variability (HRV) in 104 participants (52 with BPPV and 52 matched controls)…

This study aims to uncover genetic and biological differences between people with Menière's disease, those with vestibular migraine, and healthy individuals. Researchers will analyze blood samples from 250 participants to look for specific gene variations and biohumoral factors. …

This study tests a virtual reality (VR) game to measure hand-eye coordination in children aged 7 to 17 with and without chronic balance (vestibular) disorders. Researchers want to see if the VR tasks are reliable and fun for kids, and how balance problems affect coordination. The…

This study explores whether very small, barely noticeable movements can help retrain the brain's balance system in people with inner ear problems. Researchers will test balance and motion sensitivity in 48 adults with certain balance disorders and healthy volunteers. The goal is …

This study aims to translate and test the Situational Vertigo Questionnaire (SVQ) in Turkish. The SVQ measures dizziness triggered by visual environments like supermarkets or driving. Researchers will check if the Turkish version is valid and reliable by comparing it with other d…

This study aims to understand why people with Turner syndrome often lose their hearing. Researchers will look at genetic and epigenetic markers in 150 adults aged 18-60. Participants will have hearing, balance, blood, and imaging tests. The goal is to find new ways to treat or de…

This study measures how well people with and without vestibular (balance) disease can sense motion through vision and balance. Researchers hope to learn how aging and disease change motion perception. About 300 healthy adults and patients with balance disorders will participate i…

This study looks at whether inner-ear balance (vestibular) problems make reading harder for children with hearing loss. Researchers will test 90 children, some with normal hearing and some with severe hearing loss, measuring their ability to see clearly during head movements and …

This study looks at whether sleep disorders make vertigo worse for people with Ménière's disease, a condition that causes hearing loss, ringing in the ears, and dizziness. Researchers will track 100 adults to see if those with more severe vertigo also have more sleep problems. Th…

This study follows 19 adults with hearing loss who already received a cochlear implant that releases a steroid to reduce inflammation. Researchers will check how well the implant works over 5 years by measuring electrical signals and tracking any side effects. The goal is to see …

This study explores whether a test that measures brain waves in response to visual images can be used in a new way for people with hearing loss. Researchers will compare these brain responses to standard hearing tests and thinking skills tests. The goal is to see if this test can…