Brain ischemia

This study asks whether wearing a small heart monitor for two weeks at a time, twice, can better detect hidden irregular heartbeats (atrial fibrillation) in older adults who recently had a stroke or mini-stroke, compared to the usual 1-2 day monitoring. Atrial fibrillation is a m…

This trial tests whether starting physical therapy early—while infants are still in the NICU and continuing until 12 months corrected age—can improve motor function and reduce the severity of motor delays in babies at high risk due to premature birth, brain injury, or other condi…

This large Phase 3 study tests whether milvexian, an experimental oral blood thinner, can prevent another stroke in people who recently had a mild stroke or a high-risk mini-stroke (TIA). Over 12,500 participants are randomly assigned to receive either milvexian or a placebo, alo…

This trial tests whether a quick procedure called umbilical cord milking—pushing blood from the cord into the baby before clamping—can improve brain development in newborns who are limp or not breathing well at birth. The study follows over 3,400 infants from the earlier CORDMILK…

This study planned to test whether giving a child their own stored umbilical cord blood is safe for treating perinatal arterial ischemic stroke. It was designed for children aged 6 weeks to 6 years with MRI-confirmed stroke. The trial was withdrawn before enrolling any participan…

This study looks at 3,500 unconscious patients who survived a cardiac arrest to find the best combination of sedation, fever control, and blood pressure management in the ICU. Each patient gets one of two levels for each factor (e.g., deep vs. light sedation, tight vs. loose feve…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether two biofeedback devices—a balance platform (Huber) and a smart treadmill (C-Mill)—can improve balance and reduce fall risk in 120 older adults (65+) with chronic cerebral ischemia. Participants will do 8 sessions of training, and researchers will compare …

This study looks at whether genetic testing can help doctors pick the right antiplatelet medicine for people who have had a stroke or mini-stroke. About 350 patients will be randomly assigned to either standard care or a genetic test that checks if a common drug, clopidogrel, is …

This study compares two approaches—short-term anticoagulation (stronger blood thinners) versus antiplatelet therapy (milder blood thinners)—to prevent clots on a device placed in the heart's left atrial appendage. The trial involves 510 adults who have had this procedure. The goa…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study follows 25 people aged 2 to 65 with cerebral palsy or brain damage from lack of oxygen who have already received a new gene therapy given as a nose spray. The therapy delivers 15 genes meant to repair the brain, reduce inflammation, and improve movement and thinking. R…

This early-stage trial tests whether metformin, a common diabetes drug, is safe and feasible for infants who suffered brain injury from lack of oxygen at birth. Thirty infants under 6 months old will receive metformin for 6 weeks, with close monitoring of kidney and liver functio…

This study looks at whether giving steroids early to children who had a stroke from a condition called focal cerebral arteriopathy (FCA) can help reduce damage to the brain's arteries. About 80 children aged 1 to 18 will be randomly assigned to get steroids right away or only if …

This study tests whether giving melatonin to full-term newborns with hypoxic-ischemic encephalopathy (HIE) — a type of brain injury from lack of oxygen at birth — can improve survival and reduce brain damage. Half of the 110 babies will receive a single dose of melatonin through …

This study is checking how well a device called the GORE® CARDIOFORM Septal Occluder works and how safe it is for people who have had a stroke caused by a hole in the heart (PFO). Researchers will follow 300 patients in Japan for 12 months after the device is implanted. The goal …

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This study tests whether a video-based telehealth program, including an iPad and remote blood pressure monitoring, can help stroke survivors better control their blood pressure after leaving the hospital. The program also aims to reduce racial disparities in post-stroke care. Abo…

This study looks at better ways to find hidden atrial fibrillation (an irregular heartbeat) in people who have had a stroke. About 337 participants will use either a wearable patch for 72 hours or a handheld device three times a day to monitor their heart rhythm. The goal is to s…

This study tests whether a water-resistant, wireless ECG patch worn for 7 days can detect more cases of hidden atrial fibrillation (a heart rhythm problem that raises stroke risk) than the usual 24-hour Holter monitor. Researchers will enroll 320 adults who recently had a stroke …

This study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …

This study looks at whether clopidogrel, a blood thinner, can prevent new silent brain infarctions (small, unnoticed strokes) in people who recently had a stroke or mini-stroke. Researchers will track 134 participants over 24 months using MRI scans and cognitive tests. The goal i…

This pilot study tests a personalized lifestyle program for young adults (18-65) who have had a stroke or high-risk mini-stroke. The program includes intensive counseling on diet, exercise, and smoking, plus a wearable device to track health. Researchers want to see if this appro…

This phase 3 trial tests whether adding regular, personalized exercise to standard medical care can prevent new strokes in 1300 people with symptomatic intracranial arterial stenosis (narrowed arteries in the brain). Participants are randomly assigned to either standard care or s…

This study looks at whether aquatic therapy in a warm pool can help children ages 3-9 with conditions like cerebral palsy improve their swimming safety, arm function, and ability to do daily tasks. Children attend sessions twice a week for ten weeks. Researchers will measure chan…

This study looks at how caffeine is processed in newborns with hypoxic-ischemic encephalopathy (HIE), a brain injury caused by lack of oxygen, who are receiving cooling therapy. Researchers will test different doses of caffeine in 16 babies to find the safest and most effective a…

This study follows 800 adults who have had their first ischemic stroke in Central Norway for up to 10 years. Researchers will track how physical activity, medication use, and control of blood pressure and cholesterol affect the risk of death, another stroke, or severe disability.…

This study compares two approaches to help people with chronic traumatic brain injury (TBI) become more engaged and confident in managing their health. One approach focuses on what matters most to the patient, while the other provides general health education. The trial will invo…

This study looks at how blood flow in the feet changes during a 12-week heart and blood vessel rehab program for people with narrowed arteries. Researchers will track 80 adults with conditions like peripheral artery disease or coronary artery disease. The goal is to better unders…

This study looks at whether having a rehabilitation doctor see stroke patients early in their hospital stay can shorten how long they stay and reduce the chance of coming back. Researchers are tracking 3,000 stroke patients to see if this coordinated care approach improves recove…

This study is creating a statewide collection of blood samples and medical information from people with various brain blood vessel diseases, such as stroke and dementia. The goal is to build a resource that scientists can use in future research to better understand and potentiall…

This study looks at whether MRI or CT should be the first scan for people with suspected acute ischemic stroke. Researchers will track how often doctors follow the assigned scan type and compare outcomes. The goal is to see if a larger study comparing these imaging methods is pos…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study looks at whether a sticker-like sensor on the skin can accurately measure carbon dioxide levels in newborns with brain injury who are receiving cooling treatment. About 53 babies will take part. If it works, it could replace frequent blood draws and make monitoring eas…

This study looks at over 3,400 newborns who are not vigorous at birth (between 35 and 42 weeks). Doctors want to see if milking the umbilical cord (pushing blood into the baby) before clamping it leads to fewer cases of brain injury or death compared to clamping the cord right aw…

This study is creating a database of medical information and biological samples (blood, urine, and cheek swabs) from 1,000 newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. The goal is to measure biomarkers in the blood that cou…

This study follows about 300 children who had seizures shortly after birth to see if their genes influence whether they develop epilepsy later in childhood. Researchers will combine genetic information with brain scans and EEG results to create a risk score. No new treatments are…

This study uses MRI scans to see how the brain's blood vessels react when people breathe in extra carbon dioxide. Researchers want to compare healthy adults and those with brain blood vessel diseases. The goal is to learn more about brain blood flow and oxygen use, which could he…

This study is testing whether a device that gently stimulates a nerve in the ear is safe and tolerable for healthy children. Ten children will receive a single 30-minute session while their heart rate, oxygen levels, and brain waves are monitored. The goal is to learn how the sti…

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well th…

This study follows 1,400 women who had a stroke with no known cause. Researchers use a small implantable heart monitor to check for hidden atrial fibrillation, an irregular heartbeat that can cause strokes. The goal is to see if detecting this condition and using blood thinners c…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …