Bone development disease

This trial tests whether a calcium-rich food chew, made from milk-derived minerals, is easier for women to take daily than a standard calcium carbonate pill. Women aged 40 to 90 at increased risk for osteoporosis will be randomly assigned to one of the two forms for four weeks. T…

This study follows people with bone loss caused by long-term steroid use to compare two treatment approaches. One group received romosozumab for the first year and then switched to denosumab, while the other group took denosumab throughout. After six years, researchers will measu…

This pilot study explores whether a gentle manual therapy applied to the hip bone, in addition to standard treatment with a Pavlik harness, can improve hip joint coverage in infants with developmental dysplasia of the hip (DDH). Thirty infants aged 1 to 5 months with moderate to …

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This trial tests whether adding high-intensity laser therapy (HILT) to a physiotherapy programme can improve bone health in postmenopausal women with osteopenia or osteoporosis. Forty women will receive either real or sham laser sessions on their lower back, three times a week fo…

This study will compare two materials used for the caps that attach dentures to dental implants: acetal resin and nylon. The goal is to see which one causes less bone loss around the implants and keeps gums healthier. Twenty-two people with no teeth in their lower jaw will be enr…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This study will test whether a 12-week group exercise program is safe and practical for people with osteoporosis who have recently had a fracture. One hundred participants will attend twice-weekly classes and undergo bone scans and interviews. The goal is to see if this type of p…

This early-phase trial tests whether infusions of donor bone marrow stem cells (MSCs) are safe and can improve growth and bone health in 12 children aged 3–10 with severe osteogenesis imperfecta type 3. The study will monitor side effects, growth rates, fracture healing, and bone…

This study tests whether a new once-daily version of a probiotic food (SBD111) works as well as the current twice-daily version in healthy adults aged 35 and older. The goal is to see if the new formula leads to similar levels of helpful gut microbes. Participants take capsules f…

This trial is testing whether custom-made 3D-printed titanium implants are safe and work well for people with bone defects. Ten patients will receive an implant designed from their own CT or MRI scans. The study will track complications, implant stability, and bone healing over t…

This early-stage study aims to develop a personalized treatment for children with syndromic craniosynostosis, a group of rare genetic disorders where skull bones fuse too early. The approach uses a nano-engineered gel to deliver custom genetic medicine directly to the affected ar…

This study compares two treatments for borderline hip dysplasia: arthroscopic surgery or a 3-month non-surgical plan with education, pain relievers, supplements, and exercise. About 248 adults aged 18-42 will be randomly assigned to one of the two groups. Researchers will track p…

This study compares two bone-strengthening drugs, ibandronate and zoledronic acid, given after stopping denosumab in postmenopausal women with osteoporosis. The goal is to see which drug better maintains bone density and prevents fractures. About 52 women aged 50-85 who took deno…

This study tests a surgical procedure that uses the ligamentum teres, a natural ligament in the hip, to help stabilize the joint in children with developmental hip dysplasia (DDH). The surgery involves creating a tunnel in the bone and threading the ligament through it to improve…

This study tests whether adding denosumab to standard care can strengthen bones and prevent fractures in 358 adults with type 2 diabetes who are at high risk for breaks. Participants will receive the drug or a placebo, and researchers will measure changes in bone density and frac…

This study tests a new drug called ABSK061 in children aged 3 to 12 with achondroplasia, a common form of dwarfism. The drug is taken once daily and aims to improve growth rate. The trial will first find a safe dose, then check how well it works over a year. About 110 children wi…

This study looks at whether a short, home-based exercise program can improve bone strength in postmenopausal women with low bone density. It will compare women who are already taking bone-strengthening medication with those who are not. The goal is to see if exercise adds extra b…

This pilot study will test a small screw placed in the hip bone to help correct a wide hip angle (coxa valga) in 50 children with cerebral palsy who have early hip subluxation. The goal is to see if the screw can guide bone growth and improve hip alignment, potentially preventing…

This study looks at whether semaglutide (a diabetes drug that lowers blood sugar and helps with weight loss) affects bone density and fracture risk in people with type 2 diabetes. About 150 adults aged 50–75 will get either semaglutide plus metformin or metformin alone for 12 mon…

This study tests a surgical procedure to correct a rare condition where the two bones in the forearm are fused together, limiting rotation. The surgery involves cutting and repositioning the bones, then using Kirschner wires to hold them in place. The study will enroll one child …

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study tests whether an artificial intelligence (AI) software can accurately analyze hip ultrasound images from infants screened for developmental dysplasia of the hip (DDH). About 150 babies will have their routine hip ultrasound read by both a doctor and the AI, and researc…

This study will check whether two easy-to-use questionnaires (OST and ORAI) can accurately predict osteoporosis in 1,500 postmenopausal Turkish women aged 50-75. Researchers will compare the questionnaire results with the gold-standard DEXA bone density scan. If the tools work we…

This trial tests whether applying a 5% lidocaine plaster daily for two months can prevent chronic nerve pain after an osteoporotic vertebral fracture. Participants aged 50 and older with a recent fracture and moderate pain are randomly assigned to receive the plaster plus standar…

This study tests whether a program of exercise, lifestyle changes, and a smart chatbot can prevent osteoporosis and sarcopenia in 8,336 adults aged 40-60. Participants are split into two groups: one gets active support with structured workouts and reminders, the other gets basic …

This trial tests whether a structured 12-week physiotherapy exercise program can improve balance, posture, and reduce fall risk in people with osteoporosis. Participants, aged 50 and older, will be randomly assigned to either the exercise program or a control group. The program f…

This study compares two surgical methods for treating unstable pelvic fractures in people aged 60 and older with osteoporosis. Half of the 88 participants will receive robot-assisted minimally invasive screw placement, while the other half will have conventional open surgery. The…

This study looks at whether adding a special nerve block (PENG block) to standard spinal anesthesia can lower inflammation and pain in children aged 3 to 8 having hip surgery. One hundred children will be randomly assigned to receive either spinal anesthesia alone or spinal anest…

This study looks at whether a smartphone app that teaches cognitive behavioral therapy can help young adults (ages 15-39) with hip pain feel less depressed, anxious, and stressed. Researchers will also measure pain, physical function, and opioid use. Half of the 150 participants …

This pilot study will test whether wearing dynamic lycra shorts during daily activities can reduce pain and improve stability in adults with hip dysplasia and hypermobility. The study will enroll 12 participants and focus on whether it's feasible to run a larger trial. Researcher…

This study compares two medicines, dexmedetomidine and ketamine, added to a standard painkiller (bupivacaine) given through a caudal block to control pain after hip surgery in children aged 1 to 6 years. The goal is to see which combination provides better pain relief, lasts long…

This study compares two different lengths of time (6 weeks vs. 12 weeks) that children wear a hip cast after surgery for a dislocated hip (DDH). The goal is to see if a shorter cast time works just as well for healing and movement, with fewer problems like skin sores. About 40 ch…

This study tests whether balance training done at home via video calls works as well as in-person sessions for postmenopausal women with osteoporosis. Sixty women aged 50-70 with low bone density and balance issues will be randomly assigned to either remote or traditional trainin…

This study looks at saliva from people with osteoporosis to measure certain immune markers and an enzyme called MMP-8. Researchers also check participants' dental cavities. The goal is to better understand how osteoporosis might affect oral health. No treatments are given—only sa…

This study tracks 30 people receiving a CATALYSTEM cementless hip implant to measure how much the stem moves (subsides) in the thigh bone over two years. Using specialized CT scans, researchers aim to see if the implant stays firmly in place, which is key for long-term success. P…

This study is developing a way to predict who might develop a serious jaw bone condition called medication-related osteonecrosis of the jaw (MRONJ) after dental procedures. Researchers are following adults who have taken bone-strengthening drugs like bisphosphonates or denosumab …

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study looks at skull bone samples from 80 infants aged 3 to 12 months who have craniosynostosis, a condition where skull bones fuse too early. Researchers will measure the bone's strength, structure, and tissue makeup both near and far from the fused area. The goal is to bet…

This study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…

This study compares two ways to prepare the jawbone for dental implants in people with low bone density. One method uses Densah burs to compact bone, while the other removes bone with standard drilling. The goal is to see which gives better implant stability right after placement…

This study uses blood samples from 20 dental patients to see how well a bone-growth protein (rhBMP-2) sticks to a natural blood-derived scaffold (E-PRF) and releases over time. Researchers compare this to the standard sponge carrier and combinations. The goal is to find a better …

This study will measure two proteins (myostatin and irisin) in the blood of 60 postmenopausal women aged 50-65. Researchers will group participants by bone density (normal, low, or very low) and test their muscle strength. The goal is to see if these proteins are linked to bone a…

This study will review medical records of 8,000 adults with osteoporosis who have had a fragility fracture. Researchers want to measure how long it takes for patients to start medication that prevents future fractures. They also want to see if longer delays lead to more fractures…

This study aims to see if a structured education program based on the Health Belief Model can improve osteoporosis awareness and health beliefs in women aged 45 and older who have at least one risk factor for the disease. About 74 women will be randomly assigned to either receive…

This study is testing an AI voice assistant named Dora that makes automated phone calls to patients who have had a bone fracture. The goal is to see if Dora can safely and accurately collect information about risk factors and medication side effects, compared to a regular call fr…

This study looks at medical records and parent questionnaires from about 28 children with a rare hand condition called longitudinal ulnar deficiency. The goal is to better understand how the condition changes over time and what factors lead to surgery. No new treatments or tests …

This study aims to create an early warning system for osteoporotic vertebral compression fractures (OVCF) by combining Traditional Chinese Medicine (TCM) patterns with standard risk factors like bone density. Researchers will follow 200 adults aged 50-79 with new fractures or low…

This study looks at whether a simple, non-invasive skin test can help predict how well osteoporosis medications work. Researchers will measure substances called AGEs in the skin of 240 postmenopausal women starting treatment. The goal is to see if higher AGE levels are linked to …

This study will follow 270 children with severe positional head deformity who are already using a cranial helmet. Researchers will measure head shape changes, neck rotation, and body surface temperature using thermal imaging. The goal is to understand how helmet therapy might inf…

This study looks at how the size of the connector piece (abutment) on a dental implant affects the bone around it. Researchers will place implants in 40 adults with a missing back tooth and use either a narrow or regular abutment. Over 24 months, they will measure bone changes on…

This study will look at 35 children with joint problems that are not caused by inflammation, such as stiffness or deformity. Researchers will use exams, lab tests, and imaging to find the true cause, which could be rare genetic conditions like mucopolysaccharidoses or osteogenesi…