Could donor stem cells help kids with brittle bones grow taller and stronger?
NCT ID NCT05559801
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether infusions of donor bone marrow stem cells (MSCs) are safe and can improve growth and bone health in 12 children aged 3–10 with severe osteogenesis imperfecta type 3. The study will monitor side effects, growth rates, fracture healing, and bone density over one year. Because it is a small, non-randomized safety trial, results will be preliminary and may not lead to a proven treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- mesenchymal stromal cells (MSCs) from donor bone marrow
- What this could lead to
- If it works, this could point toward a treatment that helps children with severe brittle bone disease grow taller and have stronger bones.
- What could go wrong
- This is a very early, small trial (12 children) focused mainly on safety. It may not show clear benefit, and there are risks like infusion reactions or unknown side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for OSTEOGENESIS IMPERFECTA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Dental scans and AI could spot rare bone diseases faster
- Wearable sensors shed light on movement in brittle bone disease
- BONeMOVE: exercise boosts stamina in kids with brittle bones
- New shot aims to toughen fragile bones in rare disease
- Massive database aims to unlock secrets of facial birth defects
- Radiation-Free bone scan tested in kids