Could donor stem cells help kids with brittle bones grow taller and stronger?
NCT ID NCT05559801
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase trial tests whether infusions of donor bone marrow stem cells (MSCs) are safe and can improve growth and bone health in 12 children aged 3–10 with severe osteogenesis imperfecta type 3. The study will monitor side effects, growth rates, fracture healing, and bone density over one year. Because it is a small, non-randomized safety trial, results will be preliminary and may not lead to a proven treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mesenchymal stromal cells (MSCs) from donor bone marrow
What this could lead to
If it works, this could point toward a treatment that helps children with severe brittle bone disease grow taller and have stronger bones.
What could go wrong
This is a very early, small trial (12 children) focused mainly on safety. It may not show clear benefit, and there are risks like infusion reactions or unknown side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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