Ankle injury
MONDO:0043895Harm or hurt to the ankle or ankle joint usually inflicted by an external source.
Also known as: ankle injury, injury of ankle, injury of tarsal region, tarsal region injury, Injuries, ankle, Injuries, syndesmotic, Sprains, ankle, ankle Sprains
147 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Dissolvable screws could spare ankle fracture patients a second surgery
Disease control CompletedThis study looked at using bioabsorbable (dissolvable) screws instead of metal screws to fix a specific type of ankle injury called syndesmosis disruption. The goal was to see if these screws could hold the bones in place while they heal, then naturally dissolve, avoiding the nee…
Sponsor: NHS Grampian • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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New skin patch could replace flap surgery for leg injuries
Disease control CompletedThis study compared two ways to cover deep wounds on the lower leg, ankle, or foot: a synthetic skin patch called Integra versus traditional flap surgery (moving skin from another body part). 72 patients with traumatic skin loss were enrolled. The goal was to see which method lea…
Phase: PHASE3 • Sponsor: University Hospital, Bordeaux • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Battlefield plasma goes civil: can a powder save trauma victims?
Disease control CompletedThis study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…
Phase: PHASE3 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New study tests best emergency breathing tube for trauma victims
Disease control CompletedThis study looked at over 2,000 trauma patients who needed help breathing before arriving at the hospital. Half were given a supraglottic airway device (like an LMA or King tube) first, while the other half received standard care. The goal was to see which approach led to more pa…
Phase: NA • Sponsor: Jason Sperry • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Checklist could be lifesaver for trauma patients
Disease control CompletedThis study tested whether using the World Health Organization's trauma care checklist helps injured patients recover better. Sixty adults with trauma were randomly assigned to standard care or care with the checklist. Researchers measured pain, injury severity, complications, and…
Phase: NA • Sponsor: Khyber Teaching Hospital • Aim: Disease control
Last updated Jun 26, 2026 18:46 UTC
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New rapid test for infection and inflammation put to the test
Diagnosis CompletedThis study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…
Sponsor: LumiraDx UK Limited • Aim: Diagnosis
Last updated Jun 27, 2026 13:07 UTC
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Army tests strength and balance drills to stop ankle sprains in recruits
Prevention CompletedThis study tested whether a program of strength and balance exercises could help prevent ankle sprains in new army recruits. 786 soldiers aged 18-22 took part. They were assessed before and after the exercise program to see if their ankle stability, balance, and muscle strength i…
Phase: NA • Sponsor: University of Haifa • Aim: Prevention
Last updated Jun 27, 2026 08:14 UTC
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New rehab method may speed ankle sprain recovery
Symptom relief CompletedThis study tested whether adding perturbation-based training (unexpected movements) to standard foot-intensive rehabilitation helps people recover from ankle sprains. 36 adults aged 18-35 with recent ankle sprains were split into two groups and treated for 6 weeks. Researchers me…
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Can Non-Opioid painkillers replace opioids after ankle surgery?
Symptom relief CompletedThis study tested whether a non-opioid pain regimen (celecoxib plus acetaminophen) works as well as an opioid regimen (oxycodone plus acetaminophen) for pain after ankle arthroscopy. 112 adults were randomly assigned to one of the two groups. The goal is to find a safer way to ma…
Phase: NA • Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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New long-lasting painkiller may cut opioid use after foot surgery
Symptom relief CompletedThis study tested whether a long-acting painkiller called Exparel (liposomal bupivacaine) works better than the standard version for numbing the foot and ankle during and after surgery. About 248 adults having elective foot or ankle surgery received either Exparel or standard bup…
Phase: PHASE4 • Sponsor: St. Luke's Hospital, Pennsylvania • Aim: Symptom relief
Last updated Jun 27, 2026 12:24 UTC
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Robot buddy calms kids during bandage changes
Symptom relief CompletedThis study tested whether a social robot could reduce fear and pain in children aged 5 to 10 during wound dressing. Sixty children were split into two groups: one interacted with the robot while getting their wound dressed, and the other received standard care. Researchers measur…
Phase: NA • Sponsor: Ondokuz Mayıs University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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New device may speed up ankle sprain recovery
Symptom relief CompletedThis study tested whether adding TECAR therapy (a device that uses electrical currents) to standard exercises improves balance, pain, and daily function after an acute ankle sprain. 42 adults with grade I or II sprains were split into two groups: one did exercises alone, the othe…
Phase: NA • Sponsor: Cairo University • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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New gel combo for aching muscles: does it beat standard pain relievers?
Symptom relief CompletedThis study tested whether a gel containing piroxicam plus warming and cooling ingredients (methyl salicylate, menthol, eugenol) works as well as standard piroxicam-only or diclofenac gels for muscle and joint pain. 180 adults with conditions like ankle sprain, back pain, or knee …
Phase: PHASE3 • Sponsor: Taisho Pharmaceutical Indonesia • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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New foot training shows promise for ankle sprain relief in athletes
Symptom relief CompletedThis study looked at whether a program called Hyperarch Fascia Training (HFT) can reduce ankle pain and improve jumping ability in active adults aged 20-45 who have had ankle sprains. 62 participants were split into two groups: one did HFT exercises remotely for 12 weeks, while t…
Phase: NA • Sponsor: Applied Science & Performance Institute • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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ER osteopathy eases ankle sprains: study tests One-Time fix
Symptom relief CompletedThis study tested whether a single osteopathic session in the emergency department can improve recovery from a mild to moderate ankle sprain. Fifty adults with recent sprains were split into two groups: one got standard medical care, the other got osteopathic treatment. Researche…
Phase: NA • Sponsor: CHU de Reims • Aim: Symptom relief
Last updated Jun 27, 2026 09:07 UTC
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Ketamine may cut opioid needs for trauma patients
Symptom relief CompletedThis study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…
Phase: PHASE3 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Nerve stretching may ease Long-Term ankle pain
Symptom relief CompletedThis study looked at whether adding nerve mobilization exercises to standard balance training can improve pain, movement, and function in people with chronic ankle instability. Thirty-six adults with a history of ankle sprains and ongoing instability participated. The results cou…
Phase: NA • Sponsor: National Yang Ming Chiao Tung University • Aim: Symptom relief
Last updated Jun 27, 2026 08:11 UTC
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Teen ankle sprain study: which rehab approach works best?
Symptom relief CompletedThis study looked at two ways to help teenagers recover from a first-time ankle sprain. One group used the traditional PRICE method (rest, ice, compression, elevation) plus ibuprofen. The other group used a newer approach called PEACE and LOVE, which avoids anti-inflammatory drug…
Phase: NA • Sponsor: Lithuanian University of Health Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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New patch could ease ankle sprain pain without pills
Symptom relief CompletedThis study tested a medicated patch containing esflurbiprofen, a pain-relieving drug, against a placebo patch in 69 adults with mild ankle sprains. Participants wore the patch for 7 days. The goal was to see if the patch reduces pain during movement better than a placebo. The tri…
Phase: PHASE3 • Sponsor: Teikoku Seiyaku Co., Ltd. • Aim: Symptom relief
Last updated Jun 27, 2026 08:00 UTC
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New Mind-Body approach for wobbly ankles shows promise
Symptom relief CompletedThis study tested a new type of physical therapy that also addresses fear of movement in 36 people with chronic ankle instability. Participants attended sessions over 3 weeks, and researchers measured how many completed the program, changes in balance, and quality of life. The go…
Phase: NA • Sponsor: Creighton University • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Laser and tape ease ankle sprain pain in new study
Symptom relief CompletedThis study looked at whether low-level laser therapy combined with kinesio taping helps people with mild to moderate ankle sprains. 62 adults aged 20-40 with recent sprains took part. Researchers measured pain, range of motion, and ankle function to see if the treatments worked.
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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Paws for recovery: therapy dogs get trauma patients moving
Symptom relief CompletedThis study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…
Phase: NA • Sponsor: Andrew Bernard • Aim: Symptom relief
Last updated Jun 27, 2026 07:57 UTC
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New score could save lives of motorcycle crash victims
Knowledge-focused CompletedThis study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …
Sponsor: Antalya Health Sciences University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Do trauma patients really need that Full-Body scan?
Knowledge-focused CompletedThis completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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Tourniquets before hospital: help or hype?
Knowledge-focused CompletedThis study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Golden hour under the microscope: trauma care timing studied
Knowledge-focused CompletedThis study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…
Sponsor: Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Fall risk calculator could save lives by predicting who needs urgent care
Knowledge-focused CompletedResearchers looked at records from over 58,000 adults who had fall injuries to build a simple scoring system that estimates the chance of dying within 30 days. The tool uses age, sex, and vital signs taken in the emergency room. This study did not test any treatment—it only aimed…
Sponsor: Mackay Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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Can tailored shakes help seniors bounce back from trauma?
Knowledge-focused CompletedThis pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Blood transfusion trends in trauma: what worked and what Didn't?
Knowledge-focused CompletedThis study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…
Sponsor: Mariah Arif • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC
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Wearable tech could predict soldier injuries before they happen
Knowledge-focused CompletedThis study tested whether small body-worn sensors can predict if a soldier might get a leg injury during military training. Over 1,800 active-duty soldiers took part. The sensors measured balance and agility to see if they could spot who is at higher risk.
Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Parents' hidden trauma after Child's ICU stay revealed
Knowledge-focused CompletedThis study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Frailty index may predict trauma outcomes in seniors
Knowledge-focused CompletedThis study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Obesity's impact on hospital stays for seniors after injury examined
Knowledge-focused CompletedThis study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…
Sponsor: Methodist Health System • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Organized trauma networks may cut deaths after severe injury
Knowledge-focused CompletedThis study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Can a simple score predict who lives after trauma? new study tests it in iraq
Knowledge-focused CompletedThis study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …
Sponsor: Al-Nahrain University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Arm surgery nerve block study also checks eye pressure
Knowledge-focused CompletedThis study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…
Phase: NA • Sponsor: Pamukkale University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Ultrasound for ankle sprains: game changer or just a picture?
Knowledge-focused CompletedThis study explored whether getting an ultrasound a few days after an ankle sprain leads to better recovery after 3 months. Researchers observed 13 patients who had a follow-up visit between day 3 and day 6 after injury. The goal was to see if the ultrasound helped doctors better…
Sponsor: Hopital Nord Franche-Comte • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Smarter scans: new score could slash unnecessary radiation in kids with trauma
Knowledge-focused CompletedResearchers studied 407 children under 18 who had whole-body CT scans after trauma. They looked at injury details, physical exams, and lab results to create a scoring system called WHOLE. The goal is to help emergency doctors decide when a full-body scan is truly needed, reducing…
Sponsor: Ankara City Hospital Bilkent • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Ankle surgery outcomes under the microscope
Knowledge-focused CompletedThis study reviewed medical records of 107 patients who had surgery for a broken ankle (distal fibula fracture) using metal plates. Researchers looked at X-rays to see when the bone healed and asked patients about their function and pain one year after surgery. The goal was to be…
Sponsor: Istituto Ortopedico Rizzoli • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Severe trauma and clotting: new study reveals hidden risks
Knowledge-focused CompletedThis study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…
Sponsor: Medical University of Graz • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Healthy ankle norms for soldiers could speed injury recovery
Knowledge-focused CompletedThis study measures normal ankle function in 96 healthy military personnel using the Ankle-Go test, which combines physical exercises and questionnaires. The goal is to establish reference values for soldiers, who have different physical demands than civilians. Results will help …
Sponsor: Direction Centrale du Service de Santé des Armées • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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Ultrasound may make emergency catheter placement safer for trauma patients
Knowledge-focused CompletedThis study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Wearable sensors and AI could predict leg injuries before they happen
Knowledge-focused CompletedThis study looked at 108 healthy sports science students to see if past leg injuries leave lasting changes in walking and running patterns. Participants wore small sensors on their legs while walking and running, and filled out questionnaires about their injury history. The goal …
Sponsor: Technical University of Munich • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Massive study reveals how neck and facial bleeding affects trauma victims
Knowledge-focused CompletedThis study looked at 15,000 trauma patients treated at a Swedish hospital over 10 years. Researchers focused on those with serious neck or face injuries to understand what causes deadly bleeding and how it is managed. The goal is to improve care for future patients with these inj…
Sponsor: Karolinska University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Ankle instability holds athletes back: study shows clear performance gaps
Knowledge-focused CompletedThis study compared 16 athletes with chronic ankle instability (CAI) to 16 healthy athletes. They performed tests like jumps, hops, and agility runs. Results showed that those with CAI jumped lower, hopped shorter distances, and were slower in agility tests. The study suggests th…
Sponsor: Ankara Yildirim Beyazıt University • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:37 UTC
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Taping fails to boost performance in teens with ankle instability
Knowledge-focused CompletedThis study tested whether kinesiotape or dynamic tape improves jumping and hopping performance in 29 adolescent volleyball players with mild ankle instability. Players performed functional tests with and without tape. The results showed no significant difference between taped and…
Phase: NA • Sponsor: Yeditepe University • Aim: Knowledge-focused
Last updated Jun 26, 2026 15:59 UTC
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Scientists uncover hidden foot muscle changes after ankle sprains
Knowledge-focused CompletedThis study looked at how foot and ankle joints move and bear weight during running in people with chronic ankle instability, those who recovered from a sprain, and healthy individuals. Researchers used cameras and pressure plates to measure joint angles and forces, and ultrasound…
Phase: NA • Sponsor: Université Catholique de Louvain • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:02 UTC